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Study · Non-randomized trial · n = 17 · 1996

5 results

Hypothalamic control of growth hormone (GH) secretion in type I diabetic men: effect of the combined administration of GH-releasing hormone and hexarelin, a novel GHRP-6 analog.

Giustina A, Desenzani P, Perini P, Deghenghi R, Bugari G, Wehrenberg WB, Giustina G

Endocrine research1 May 1996Cited by 6 (Europe PMC)

PMID8799695 (opens in a new tab)DOI10.1080/07435809609030505 (opens in a new tab)PepBankPUB-08799695
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In men with type I diabetes, the GH response to hexarelin was significantly greater than in normal men.

    In plain wordsIn men with type 1 diabetes, hexarelin raised growth hormone more than it did in men without diabetes.

    Peptide
    Hexarelin
    Outcome
    IncreaseGH response to hexarelin, type I diabetic versus normal men
    Study

    n = 17

    Comparator
    Normal men
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    100 micrograms · intravenous bolus · single doseAs given in this study (human).

    Source sentences

    Summary
    In type I diabetic patients significantly greater GH responses to GHRH and hexarelin have been observed with normal subjects.
    2 context sentences
    Summary · context
    The aim of our study was to evaluate the effects of hexarelin and GHRH, administered either alone or in combination, on GH secretion in 10 type I diabetic and 7 normal men.
    Summary · context
    All the subjects were administered: 1) human GHRH (1-29) NH2 100 micrograms i.v. bolus at 0 min; 2) hexarelin 100 micrograms i.v. bolus at 0 min; 3) hexarelin 100 micrograms + hGHRH 100 micrograms i.v. bolus at 0 min.
  2. 02HumanNon-randomized trialEfficacy outcome

    In type I diabetic and normal men, hexarelin caused a significantly greater GH response than GHRH.

    In plain wordsIn men with and without type 1 diabetes, hexarelin raised growth hormone more than GHRH did.

    Peptide
    Hexarelin
    Outcome
    IncreaseGH response to hexarelin versus GHRH
    Study

    n = 17

    Comparator
    GHRH
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    100 micrograms · intravenous bolus · single doseAs given in this study (human).

    Source sentences

    Summary
    Hexarelin caused a significantly (p < 0.05) greater GH response as compared to GHRH in both diabetic and control subjects.
    2 context sentences
    Summary · context
    The aim of our study was to evaluate the effects of hexarelin and GHRH, administered either alone or in combination, on GH secretion in 10 type I diabetic and 7 normal men.
    Summary · context
    All the subjects were administered: 1) human GHRH (1-29) NH2 100 micrograms i.v. bolus at 0 min; 2) hexarelin 100 micrograms i.v. bolus at 0 min; 3) hexarelin 100 micrograms + hGHRH 100 micrograms i.v. bolus at 0 min.

Studies that did not test the peptide alone3

In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Hexarelin.

  1. 03HumanNot a test of Hexarelin aloneNon-randomized trialEfficacy outcome

    In type I diabetic and normal men, hexarelin plus GHRH raised GH absolute and peak levels more than hexarelin or GHRH alone.

    In plain wordsIn men with and without type 1 diabetes, hexarelin and GHRH together raised growth hormone more than either one alone.

    Peptide
    Hexarelin
    Outcome
    IncreaseGH response to hexarelin plus GHRH versus each alone
    Study

    n = 17

    Comparator
    Hexarelin alone or GHRH alone
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    After the administration of hexarelin+GHRH, a significant increase in both GH absolute and peak levels as compared to hexarelin or GHRH alone was found in all the subjects.
    2 context sentences
    Summary · context
    The aim of our study was to evaluate the effects of hexarelin and GHRH, administered either alone or in combination, on GH secretion in 10 type I diabetic and 7 normal men.
    Summary · context
    All the subjects were administered: 1) human GHRH (1-29) NH2 100 micrograms i.v. bolus at 0 min; 2) hexarelin 100 micrograms i.v. bolus at 0 min; 3) hexarelin 100 micrograms + hGHRH 100 micrograms i.v. bolus at 0 min.

    In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.

  2. 04HumanNot a test of Hexarelin aloneNon-randomized trialEfficacy outcome

    The GH responses to hexarelin plus GHRH were not significantly different in type I diabetic men and normal men.

    In plain wordsHexarelin and GHRH together raised growth hormone to a similar extent in men with and without type 1 diabetes.

    Peptide
    Hexarelin
    Outcome
    No significant changeGH response to hexarelin plus GHRH, diabetic versus normal men
    Study

    n = 17

    Comparator
    Normal men
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    However, the GH responses to the combined stimuli were not significantly different in diabetics as compared to normals
    2 context sentences
    Summary · context
    The aim of our study was to evaluate the effects of hexarelin and GHRH, administered either alone or in combination, on GH secretion in 10 type I diabetic and 7 normal men.
    Summary · context
    All the subjects were administered: 1) human GHRH (1-29) NH2 100 micrograms i.v. bolus at 0 min; 2) hexarelin 100 micrograms i.v. bolus at 0 min; 3) hexarelin 100 micrograms + hGHRH 100 micrograms i.v. bolus at 0 min.

    In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.

  3. 05HumanNot a test of Hexarelin aloneNon-randomized trialMechanism

    The interaction of GHRH and hexarelin was synergistic in normal men and additive in type I diabetic men.

    In plain wordsGHRH and hexarelin together had a synergistic effect in men without diabetes and an additive effect in men with type 1 diabetes.

    Peptide
    Hexarelin
    Outcome
    Not applicableInteraction of GHRH and hexarelin
    Study

    n = 17

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    moreover, the interaction of GHRH and hexarelin was synergistic in controls and additive in diabetics.
    2 context sentences
    Summary · context
    The aim of our study was to evaluate the effects of hexarelin and GHRH, administered either alone or in combination, on GH secretion in 10 type I diabetic and 7 normal men.
    Summary · context
    All the subjects were administered: 1) human GHRH (1-29) NH2 100 micrograms i.v. bolus at 0 min; 2) hexarelin 100 micrograms i.v. bolus at 0 min; 3) hexarelin 100 micrograms + hGHRH 100 micrograms i.v. bolus at 0 min.

    In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 4Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Versions 2 to 3

    13 Oct 2026, 16:31 UTC

    The same notice was added 2 times, first on 9 Oct 2026, 03:13 UTC. The status did not change between them.

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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