Beneficial effect of a novel pentadecapeptide BPC 157 on gastric lesions induced by restraint stress, ethanol, indomethacin, and capsaicin neurotoxicity.

Sikirić P, Seiwerth S, Grabarević Z, Rucman R, Petek M, Jagić V, Turković B, Rotkvić I, Mise S, Zoricić I, Gjurasin M, Konjevoda P and 9 more

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Separović J, Ljubanović D, Artuković B, Bratulić M, Tisljar M, Jurina L, Buljat G, Miklić P, Marović A

Digestive diseases and sciences1 Aug 1996Cited by 48 (Europe PMC)

PMID8769287DOI10.1007/bf02087908PepBankPUB-08769287

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

7 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats, BPC‑157 protected the gastric mucosa against ethanol-induced lesions in the absence of capsaicin.
In plain wordsIn rats, BPC‑157 protected the stomach lining from damage caused by ethanol.
Peptide
BPC-157
Outcome
DecreaseGastric lesions induced by ethanol
Study
ratn: not reported in source
Gastric lesion models
Comparator
Control
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
10 micrograms/kg and 10 ng/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
In the absence of capsaicin, BPC 157 protected gastric mucosa against ethanol, restraint, and indomethacin application.
1 context sentence(design, population, supporting numbers)
Summary · context
Therefore, from this viewpoint, we have studied the gastroprotective effect of the pentadecapeptide BPC 157, on gastric lesions produced in rats by 96% ethanol, restraint stress, and indomethacin.
Report a problemFND-0876928701
02AnimalAnimal study (in vivo)Efficacy outcome
In rats, BPC‑157 protected the gastric mucosa against restraint-induced lesions in the absence of capsaicin.
In plain wordsIn rats, BPC‑157 protected the stomach lining from damage caused by restraint stress.
Peptide
BPC-157
Outcome
DecreaseGastric lesions induced by restraint stress
Study
ratn: not reported in source
Gastric lesion models
Comparator
Control
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
10 micrograms/kg and 10 ng/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
In the absence of capsaicin, BPC 157 protected gastric mucosa against ethanol, restraint, and indomethacin application.
1 context sentence(design, population, supporting numbers)
Summary · context
Therefore, from this viewpoint, we have studied the gastroprotective effect of the pentadecapeptide BPC 157, on gastric lesions produced in rats by 96% ethanol, restraint stress, and indomethacin.
Report a problemFND-0876928702
03AnimalAnimal study (in vivo)Efficacy outcome
In rats, BPC‑157 protected the gastric mucosa against indomethacin-induced lesions in the absence of capsaicin.
In plain wordsIn rats, BPC‑157 protected the stomach lining from damage caused by indomethacin.
Peptide
BPC-157
Outcome
DecreaseGastric lesions induced by indomethacin
Study
ratn: not reported in source
Gastric lesion models
Comparator
Control
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
10 micrograms/kg and 10 ng/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
In the absence of capsaicin, BPC 157 protected gastric mucosa against ethanol, restraint, and indomethacin application.
1 context sentence(design, population, supporting numbers)
Summary · context
Therefore, from this viewpoint, we have studied the gastroprotective effect of the pentadecapeptide BPC 157, on gastric lesions produced in rats by 96% ethanol, restraint stress, and indomethacin.
Report a problemFND-0876928703
04AnimalAnimal study (in vivo)Mechanism
In rats, neurotoxic doses of capsaicin consistently affected the protective activity of BPC‑157 against restraint, ethanol or indomethacin lesions.
In plain wordsIn rats, damaging sensory nerves with capsaicin affected how well BPC‑157 protected the stomach.
Peptide
BPC-157
Outcome
DecreaseBPC 157 activity with neurotoxic capsaicin
Study
ratn: not reported in source
Gastric lesion models
Comparator
Control
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
10 micrograms/kg and 10 ng/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
In the presence of neurotoxic doses of capsaicin, the negative influence of capsaicin on restraint, ethanol, or indomethacin lesions consistently affected salutary activity of BPC 157.
1 context sentence(design, population, supporting numbers)
Summary · context
Therefore, from this viewpoint, we have studied the gastroprotective effect of the pentadecapeptide BPC 157, on gastric lesions produced in rats by 96% ethanol, restraint stress, and indomethacin.
Report a problemFND-0876928704
05AnimalAnimal study (in vivo)Efficacy outcome
In capsaicin-treated rats (adult or neonatal), BPC‑157 protection against gastric lesions was still evident in all assays.
In plain wordsIn rats whose sensory nerves were damaged with capsaicin, BPC‑157 still protected the stomach.
Peptide
BPC-157
Outcome
DecreaseBPC 157 protection in capsaicin-treated rats
Study
ratn: not reported in source
Gastric lesion models
Comparator
Control
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
10 micrograms/kg and 10 ng/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
However, BPC 157 protection was still evident in the capsaicin-treated rats (either treated as adults or as newborns) in all of these assays.
1 context sentence(design, population, supporting numbers)
Summary · context
Therefore, from this viewpoint, we have studied the gastroprotective effect of the pentadecapeptide BPC 157, on gastric lesions produced in rats by 96% ethanol, restraint stress, and indomethacin.
Report a problemFND-0876928705
06AnimalAnimal study (in vivo)Mechanism
In rats treated with capsaicin as newborns, gastroprotection was completely abolished when BPC‑157 was applied as a single nanogram regimen.
In plain wordsIn rats given capsaicin as newborns, a single nanogram dose of BPC‑157 gave no stomach protection.
Peptide
BPC-157
Outcome
No significant changeSingle nanogram BPC 157 regimen after neonatal capsaicin
Study
ratn: not reported in source
Gastric lesion models
Comparator
Neonatal capsaicin-treated control
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
10 ng/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
after neonatal capsaicin treatment, a complete abolition of BPC gastroprotection was noted if BPC 157 was applied as a single nanogram-regimen
1 context sentence(design, population, supporting numbers)
Summary · context
Therefore, from this viewpoint, we have studied the gastroprotective effect of the pentadecapeptide BPC 157, on gastric lesions produced in rats by 96% ethanol, restraint stress, and indomethacin.
Report a problemFND-0876928706
07AnimalAnimal study (in vivo)Mechanism
In rats treated with capsaicin as newborns, mucosal protection was fully reversed when the same BPC‑157 nanogram dose was used daily.
In plain wordsIn rats given capsaicin as newborns, the same nanogram dose of BPC‑157 given daily brought back full stomach protection.
Peptide
BPC-157
Outcome
DecreaseDaily nanogram BPC 157 regimen after neonatal capsaicin
Study
ratn: not reported in source
Gastric lesion models
Comparator
Neonatal capsaicin-treated control
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
10 ng/kg · intraperitoneal · dailyAs given in this study (rat).
Source sentences
Summary
but the mucosal protection was fully reversed when the same dose was used daily.
1 context sentence(design, population, supporting numbers)
Summary · context
Therefore, from this viewpoint, we have studied the gastroprotective effect of the pentadecapeptide BPC 157, on gastric lesions produced in rats by 96% ethanol, restraint stress, and indomethacin.
Report a problemFND-0876928707

Studies that did not test the peptide alone1

In this study, BPC-157 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking BPC-157.

08AnimalNot a test of BPC-157 aloneAnimal study (in vivo)Mechanism
In rats given an excitatory low dose of capsaicin together with BPC‑157, the protective effectiveness appeared to be increased.
In plain wordsIn rats, low-dose capsaicin given with BPC‑157 appeared to increase the stomach protection.
Peptide
BPC-157
Outcome
IncreaseBPC 157 effectiveness with excitatory low-dose capsaicin
Study
ratn: not reported in source
Gastric lesion models
Comparator
BPC 157 without capsaicin
Outcome group
Gastrointestinal protection · Gastrointestinal
Source sentences
Summary
In line with the excitatory dose of capsaicin the beneficial effectiveness of BPC 157 appears to be increased as well.
1 context sentence(design, population, supporting numbers)
Summary · context
Therefore, from this viewpoint, we have studied the gastroprotective effect of the pentadecapeptide BPC 157, on gastric lesions produced in rats by 96% ethanol, restraint stress, and indomethacin.
In this study, BPC-157 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking BPC-157.
Report a problemFND-0876928708

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
10 Oct 2026, 08:19 UTC
Study results updated
Version 2
9 Oct 2026, 03:03 UTC
Study data updated · source update from Europe PMC
Version 1
9 Oct 2026, 02:56 UTC
First added · source update from Europe PMC

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