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Study · Randomized controlled trial · n = 9 · 1996

10 results

Effects of a 7-day treatment with a novel, orally active, growth hormone (GH) secretagogue, MK-677, on 24-hour GH profiles, insulin-like growth factor I, and adrenocortical function in normal young men.

Copinschi G, Van Onderbergen A, L'Hermite-Balériaux M, Mendel CM, Caufriez A, Leproult R, Bolognese JA, De Smet M, Thorner MO, Van Cauter E

The Journal of clinical endocrinology and metabolism1 Aug 1996Cited by 37 (Europe PMC)

PMID8768828 (opens in a new tab)DOI10.1210/jcem.81.8.8768828 (opens in a new tab)PepBankPUB-08768828
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. 10 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In healthy young men, the amount of GH secreted was similar with 5 mg MK‑677, 25 mg MK‑677 and placebo.

    In plain wordsIn healthy young men, the amount of growth hormone secreted was similar with MK‑677 and with placebo.

    Peptide
    MK-677 (ibutamoren)
    Outcome
    No significant changeAmount of GH secreted
    Study

    n = 9

    Comparator
    Placebo
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    5 and 25 mg · oral · 7 daysAs given in this study (human).

    Source sentences

    Summary
    The amounts of GH secreted were similar in all three conditions, but GH pulse frequency was increased with both dosages of the drug, primarily because of an increase in the number of low amplitude pulses.
    2 context sentences
    Summary · context
    To assess the effects of prolonged administration of a novel analog of GH-releasing peptide (MK-677), nine healthy young men participated in a randomized, double blind, three-period cross-over comparison of orally administered placebo and 5- and 25-mg doses of MK-677.
    Summary · context
    Each period involved bedtime administration of the drug for 7 consecutive days.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In healthy young men, both 5 mg and 25 mg MK‑677 increased GH pulse frequency compared with placebo, mainly through more low-amplitude pulses.

    In plain wordsIn healthy young men, both MK‑677 doses increased how often growth hormone pulses occurred, compared with placebo.

    Peptide
    MK-677 (ibutamoren)
    Outcome
    IncreaseGH pulse frequency
    Study

    n = 9

    Comparator
    Placebo
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    5 and 25 mg · oral · 7 daysAs given in this study (human).

    Source sentences

    Summary
    The amounts of GH secreted were similar in all three conditions, but GH pulse frequency was increased with both dosages of the drug, primarily because of an increase in the number of low amplitude pulses.
    2 context sentences
    Summary · context
    To assess the effects of prolonged administration of a novel analog of GH-releasing peptide (MK-677), nine healthy young men participated in a randomized, double blind, three-period cross-over comparison of orally administered placebo and 5- and 25-mg doses of MK-677.
    Summary · context
    Each period involved bedtime administration of the drug for 7 consecutive days.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In young men, MK‑677 increased IGF-I in a dose-dependent manner compared with placebo.

    In plain wordsIn young men, MK‑677 increased IGF-I in a dose-dependent manner compared with placebo.

    Peptide
    MK-677 (ibutamoren)
    Outcome
    IncreaseIGF-I concentration
    Study

    n = 9

    Comparator
    Placebo
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    5 and 25 mg · oral · 7 daysAs given in this study (human).

    Source sentences

    Summary
    Plasma IGF-I levels were increased in a dose-dependent manner, whereas IGFBP-3 levels were increased only with the highest dosage.
    2 context sentences
    Summary · context
    To assess the effects of prolonged administration of a novel analog of GH-releasing peptide (MK-677), nine healthy young men participated in a randomized, double blind, three-period cross-over comparison of orally administered placebo and 5- and 25-mg doses of MK-677.
    Summary · context
    Each period involved bedtime administration of the drug for 7 consecutive days.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In young men, only the highest MK‑677 dose increased IGFBP-3 compared with placebo.

    In plain wordsIn young men, only the highest MK‑677 dose increased IGFBP-3 compared with placebo.

    Peptide
    MK-677 (ibutamoren)
    Outcome
    IncreaseIGFBP-3 at higher dose
    Study

    n = 9

    Comparator
    Placebo
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    25 mg · oral · 7 daysAs given in this study (human).

    Source sentences

    Summary
    Plasma IGF-I levels were increased in a dose-dependent manner, whereas IGFBP-3 levels were increased only with the highest dosage.
    2 context sentences
    Summary · context
    To assess the effects of prolonged administration of a novel analog of GH-releasing peptide (MK-677), nine healthy young men participated in a randomized, double blind, three-period cross-over comparison of orally administered placebo and 5- and 25-mg doses of MK-677.
    Summary · context
    Each period involved bedtime administration of the drug for 7 consecutive days.
  5. 05HumanRandomized controlled trialMechanism

    In young men receiving MK‑677, GH pulse frequency was positively related to IGF-I increase.

    In plain wordsIn young men receiving MK‑677, growth hormone pulse frequency was linked to greater IGF-I increases.

    Peptide
    MK-677 (ibutamoren)
    Outcome
    IncreaseGH pulse frequency association with IGF-I increase
    Study

    n = 9

    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated · oral · 7 daysAs given in this study (human).

    Source sentences

    Summary
    There was a positive relationship between GH pulse frequency and IGF-I increase.
    2 context sentences
    Summary · context
    To assess the effects of prolonged administration of a novel analog of GH-releasing peptide (MK-677), nine healthy young men participated in a randomized, double blind, three-period cross-over comparison of orally administered placebo and 5- and 25-mg doses of MK-677.
    Summary · context
    Each period involved bedtime administration of the drug for 7 consecutive days.
  6. 06HumanRandomized controlled trialEfficacy outcome

    In young men, MK‑677 advanced the nocturnal cortisol nadir compared with placebo.

    In plain wordsIn young men, the nighttime cortisol minimum occurred earlier with MK‑677 than with placebo.

    Peptide
    MK-677 (ibutamoren)
    Outcome
    Not applicableTiming of nocturnal cortisol nadir
    Study

    n = 9

    Comparator
    Placebo
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    Dose not stated · oral · 7 daysAs given in this study (human).

    Source sentences

    Summary
    Except for an advance in the nocturnal nadir and in the morning elevation, MK-677 had no effect on cortisol profiles.
    2 context sentences
    Summary · context
    To assess the effects of prolonged administration of a novel analog of GH-releasing peptide (MK-677), nine healthy young men participated in a randomized, double blind, three-period cross-over comparison of orally administered placebo and 5- and 25-mg doses of MK-677.
    Summary · context
    Each period involved bedtime administration of the drug for 7 consecutive days.
  7. 07HumanRandomized controlled trialEfficacy outcome

    In young men, mean total plasma cortisol was similar under MK‑677 and placebo conditions.

    In plain wordsIn young men, mean total plasma cortisol was similar under MK‑677 and placebo conditions.

    Peptide
    MK-677 (ibutamoren)
    Outcome
    No significant changeMean total plasma cortisol
    Study

    n = 9

    Comparator
    Placebo
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    5 and 25 mg · oral · 7 daysAs given in this study (human).

    Source sentences

    Summary
    In particular, 24-h mean levels of plasma total and free cortisol and urinary excretion of free cortisol were similar under all conditions.
    2 context sentences
    Summary · context
    To assess the effects of prolonged administration of a novel analog of GH-releasing peptide (MK-677), nine healthy young men participated in a randomized, double blind, three-period cross-over comparison of orally administered placebo and 5- and 25-mg doses of MK-677.
    Summary · context
    Each period involved bedtime administration of the drug for 7 consecutive days.
  8. 08HumanRandomized controlled trialEfficacy outcome

    In young men, mean free plasma cortisol was similar under MK‑677 and placebo conditions.

    In plain wordsIn young men, mean free plasma cortisol was similar under MK‑677 and placebo conditions.

    Peptide
    MK-677 (ibutamoren)
    Outcome
    No significant changeMean free plasma cortisol
    Study

    n = 9

    Comparator
    Placebo
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    5 and 25 mg · oral · 7 daysAs given in this study (human).

    Source sentences

    Summary
    In particular, 24-h mean levels of plasma total and free cortisol and urinary excretion of free cortisol were similar under all conditions.
    2 context sentences
    Summary · context
    To assess the effects of prolonged administration of a novel analog of GH-releasing peptide (MK-677), nine healthy young men participated in a randomized, double blind, three-period cross-over comparison of orally administered placebo and 5- and 25-mg doses of MK-677.
    Summary · context
    Each period involved bedtime administration of the drug for 7 consecutive days.
  9. 09HumanRandomized controlled trialEfficacy outcome

    In young men, urinary free cortisol excretion was similar under MK‑677 and placebo conditions.

    In plain wordsIn young men, urinary free cortisol excretion was similar under MK‑677 and placebo conditions.

    Peptide
    MK-677 (ibutamoren)
    Outcome
    No significant changeUrinary free cortisol excretion
    Study

    n = 9

    Comparator
    Placebo
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    5 and 25 mg · oral · 7 daysAs given in this study (human).

    Source sentences

    Summary
    In particular, 24-h mean levels of plasma total and free cortisol and urinary excretion of free cortisol were similar under all conditions.
    2 context sentences
    Summary · context
    To assess the effects of prolonged administration of a novel analog of GH-releasing peptide (MK-677), nine healthy young men participated in a randomized, double blind, three-period cross-over comparison of orally administered placebo and 5- and 25-mg doses of MK-677.
    Summary · context
    Each period involved bedtime administration of the drug for 7 consecutive days.
  10. 10HumanRandomized controlled trialEfficacy outcome

    In young men, MK‑677 advanced the morning cortisol elevation compared with placebo.

    In plain wordsIn young men, the morning cortisol rise occurred earlier with MK‑677 than with placebo.

    Peptide
    MK-677 (ibutamoren)
    Outcome
    Not applicableTiming of morning cortisol elevation
    Study

    n = 9

    Comparator
    Placebo
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    Dose not stated · oral · 7 daysAs given in this study (human).

    Source sentences

    Summary
    Except for an advance in the nocturnal nadir and in the morning elevation, MK-677 had no effect on cortisol profiles.
    2 context sentences
    Summary · context
    To assess the effects of prolonged administration of a novel analog of GH-releasing peptide (MK-677), nine healthy young men participated in a randomized, double blind, three-period cross-over comparison of orally administered placebo and 5- and 25-mg doses of MK-677.
    Summary · context
    Each period involved bedtime administration of the drug for 7 consecutive days.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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