In male rats, triptorelin pretreatment suppressed LHRH-stimulated LH secretion at 30 min by approximately 33% versus LHRH alone.
In plain wordsIn rats, triptorelin pretreatment reduced stimulated LH secretion by approximately 33% versus LHRH alone.
- Outcome
- DecreaseStimulated LH secretion
- Study
ratn: not reported in source
Male rats- Comparator
- LHRH alone
- Outcome group
- Sex hormones and fertility · Endocrine and hormones
- Studied dose
- 100 micrograms/animal-day · subcutaneous · 4 weeksAs given in this study (rat).
Source sentences
Our data show that LHRH-stimulated LH secretion at 30 min was suppressed by approximately 33% (P < 0.01) in rats pretreated with [D-Trp6]LHRH compared to that in animals injected with LHRH alone.
1 context sentence(design, population, supporting numbers)
we treated male rats for 4 weeks with daily sc injections of LHRH antagonist [Ac-D-Nal2,Phe(4Cl)2,D-Pal(3)3, D-Cit6,D-Ala10]LHRH (Cetrorelix acetate) or LHRH agonist, [D-Trp6]LHRH, in doses of 100 micrograms/animal-day.