Short-term effects of methylene blue on hemodynamics and gas exchange in humans with septic shock.

Gachot B, Bedos JP, Veber B, Wolff M, Regnier B

Intensive care medicine1 Dec 1995Cited by 72 (Europe PMC)

PMID8750129DOI10.1007/bf01700666PepBankPUB-08750129

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study17

17 results from studies that gave the peptide. 17 results from people.

01HumanNon-randomized trialEfficacy outcome
In patients with septic shock, methylene blue increased mean arterial pressure compared with baseline.
In plain wordsMethylene blue increased mean blood pressure compared with baseline in patients with septic shock.
Peptide
Methylene blue
Outcome
IncreaseMean arterial pressure
Study
n = 6
Comparator
Baseline
Outcome group
Blood pressure · Cardiovascular
Studied dose
3 mg kg(-1) · intravenousAs given in this study (human).
Measurements
Mean arterial pressure
69.7 mmHg
Before methylene blue (+/- 4.5)
Mean arterial pressure
83.7 mmHg
20 min after infusion (+/- 5.1)
Source sentences
Summary
Methylene blue increased the mean arterial pressure from 69.7 +/- 4.5 to 83.7 +/- 5.1 mmHg (p = 0.028) and the mean pulmonary artery pressure, from 34.3 +/- 7.2 to 38.7 +/- 8.0 mmHg (p = 0.023).
3 context sentences(design, population, supporting numbers)
Summary · context
A prospective, open, single-dose study.
Summary · context
Six patients with severe septic shock.
Summary · context
Complete hemodynamic values were recorded before and 20 min after the infusion of intravenous MB (3 mg kg(-1)).
Report a problemFND-0875012901
02HumanNon-randomized trialEfficacy outcome
In patients with septic shock, methylene blue increased mean pulmonary artery pressure compared with baseline.
In plain wordsMethylene blue increased lung artery pressure compared with baseline in patients with septic shock.
Peptide
Methylene blue
Outcome
IncreaseMean pulmonary artery pressure
Study
n = 6
Comparator
Baseline
Outcome group
Blood pressure · Cardiovascular
Studied dose
3 mg kg(-1) · intravenousAs given in this study (human).
Measurements
Mean pulmonary artery pressure
34.3 mmHg
Before methylene blue (+/- 7.2)
Mean pulmonary artery pressure
38.7 mmHg
20 min after infusion (+/- 8.0)
Source sentences
Summary
Methylene blue increased the mean arterial pressure from 69.7 +/- 4.5 to 83.7 +/- 5.1 mmHg (p = 0.028) and the mean pulmonary artery pressure, from 34.3 +/- 7.2 to 38.7 +/- 8.0 mmHg (p = 0.023).
3 context sentences(design, population, supporting numbers)
Summary · context
A prospective, open, single-dose study.
Summary · context
Six patients with severe septic shock.
Summary · context
Complete hemodynamic values were recorded before and 20 min after the infusion of intravenous MB (3 mg kg(-1)).
Report a problemFND-0875012902
03HumanNon-randomized trialEfficacy outcome
In patients with septic shock, methylene blue increased systemic vascular resistance index compared with baseline.
In plain wordsMethylene blue increased blood vessel resistance compared with baseline in patients with septic shock.
Peptide
Methylene blue
Outcome
IncreaseSystemic vascular resistance index
Study
n = 6
Comparator
Baseline
Outcome group
Vascular function · Cardiovascular
Studied dose
3 mg kg(-1) · intravenousAs given in this study (human).
Measurements
Systemic vascular resistance index
703.1 dyne.s.cm(-5).m(-2)
Before methylene blue (+/- 120.6)
Systemic vascular resistance index
903.7 dyne.s.cm(-5).m(-2)
20 min after infusion (+/- 152.2)
Source sentences
Summary
Systemic vascular resistance index was increased from 703.1 +/- 120.6 to 903.7 +/- 152.2 dyne.s.cm(-5).m(-2) (p = 0.028) and pulmonary vascular resistance index, from 254.6 +/- 96.9 to 342.2 +/- 118.9 dyne.s.cm(-5) .m(-2) (p = 0.027).
3 context sentences(design, population, supporting numbers)
Summary · context
A prospective, open, single-dose study.
Summary · context
Six patients with severe septic shock.
Summary · context
Complete hemodynamic values were recorded before and 20 min after the infusion of intravenous MB (3 mg kg(-1)).
Report a problemFND-0875012903
04HumanNon-randomized trialEfficacy outcome
In patients with septic shock, methylene blue increased pulmonary vascular resistance index compared with baseline.
In plain wordsMethylene blue increased lung blood vessel resistance compared with baseline in patients with septic shock.
Peptide
Methylene blue
Outcome
IncreasePulmonary vascular resistance index
Study
n = 6
Comparator
Baseline
Outcome group
Vascular function · Cardiovascular
Studied dose
3 mg kg(-1) · intravenousAs given in this study (human).
Measurements
Pulmonary vascular resistance index
254.6 dyne.s.cm(-5) .m(-2)
Before methylene blue (+/- 96.9)
Pulmonary vascular resistance index
342.2 dyne.s.cm(-5) .m(-2)
20 min after infusion (+/- 118.9)
Source sentences
Summary
Systemic vascular resistance index was increased from 703.1 +/- 120.6 to 903.7 +/- 152.2 dyne.s.cm(-5).m(-2) (p = 0.028) and pulmonary vascular resistance index, from 254.6 +/- 96.9 to 342.2 +/- 118.9 dyne.s.cm(-5) .m(-2) (p = 0.027).
3 context sentences(design, population, supporting numbers)
Summary · context
A prospective, open, single-dose study.
Summary · context
Six patients with severe septic shock.
Summary · context
Complete hemodynamic values were recorded before and 20 min after the infusion of intravenous MB (3 mg kg(-1)).
Report a problemFND-0875012904
05HumanNon-randomized trialEfficacy outcome
In patients with septic shock, methylene blue decreased the PaO2/FIO2 ratio compared with baseline.
In plain wordsMethylene blue reduced the blood oxygen to inhaled oxygen ratio compared with baseline in patients with septic shock.
Peptide
Methylene blue
Outcome
DecreasePaO2/FIO2 ratio
Study
n = 6
Comparator
Baseline
Outcome group
Respiratory function · Respiratory
Studied dose
3 mg kg(-1) · intravenousAs given in this study (human).
Measurements
PaO2/FIO2
229.2 mmHg
Before methylene blue (+/- 54.4)
PaO2/FIO2
162.2 mmHg
20 min after infusion (+/- 44.1)
Source sentences
Summary
The PaO2/FIO2 decreased from 229.2 +/- 54.4 to 162.2 +/- 44.1 mmHg (p = 0.028), without significant modification of intrapulmonary shunting.
3 context sentences(design, population, supporting numbers)
Summary · context
A prospective, open, single-dose study.
Summary · context
Six patients with severe septic shock.
Summary · context
Complete hemodynamic values were recorded before and 20 min after the infusion of intravenous MB (3 mg kg(-1)).
Report a problemFND-0875012905
06HumanNon-randomized trialEfficacy outcome
In patients with septic shock, intrapulmonary shunting did not change significantly after methylene blue.
In plain wordsBlood flow bypassing lung oxygen exchange did not change significantly from baseline after methylene blue in patients with septic shock.
Peptide
Methylene blue
Outcome
No significant changeIntrapulmonary shunting
Study
n = 6
Comparator
Baseline
Outcome group
Respiratory function · Respiratory
Studied dose
3 mg kg(-1) · intravenousAs given in this study (human).
Source sentences
Summary
The PaO2/FIO2 decreased from 229.2 +/- 54.4 to 162.2 +/- 44.1 mmHg (p = 0.028), without significant modification of intrapulmonary shunting.
3 context sentences(design, population, supporting numbers)
Summary · context
A prospective, open, single-dose study.
Summary · context
Six patients with severe septic shock.
Summary · context
Complete hemodynamic values were recorded before and 20 min after the infusion of intravenous MB (3 mg kg(-1)).
Report a problemFND-0875012906
07HumanNon-randomized trialEfficacy outcome
In patients with septic shock, heart rate remained essentially unchanged after methylene blue.
In plain wordsHeart rate remained essentially unchanged from baseline after methylene blue in patients with septic shock.
Peptide
Methylene blue
Outcome
No significant changeHeart rate
Study
n = 6
Comparator
Baseline
Outcome group
Heart function · Cardiovascular
Studied dose
3 mg kg(-1) · intravenousAs given in this study (human).
Source sentences
Summary
Heart rate, cardiac index, right atrial pressure, DO2, VO2, oxygen extraction and arterial lactate were essentially unchanged.
3 context sentences(design, population, supporting numbers)
Summary · context
A prospective, open, single-dose study.
Summary · context
Six patients with severe septic shock.
Summary · context
Complete hemodynamic values were recorded before and 20 min after the infusion of intravenous MB (3 mg kg(-1)).
Report a problemFND-0875012907
08HumanNon-randomized trialEfficacy outcome
In patients with septic shock, cardiac index remained essentially unchanged after methylene blue.
In plain wordsHeart pumping output relative to body size remained essentially unchanged from baseline after methylene blue in patients with septic shock.
Peptide
Methylene blue
Outcome
No significant changeCardiac index
Study
n = 6
Comparator
Baseline
Outcome group
Heart function · Cardiovascular
Studied dose
3 mg kg(-1) · intravenousAs given in this study (human).
Source sentences
Summary
Heart rate, cardiac index, right atrial pressure, DO2, VO2, oxygen extraction and arterial lactate were essentially unchanged.
3 context sentences(design, population, supporting numbers)
Summary · context
A prospective, open, single-dose study.
Summary · context
Six patients with severe septic shock.
Summary · context
Complete hemodynamic values were recorded before and 20 min after the infusion of intravenous MB (3 mg kg(-1)).
Report a problemFND-0875012908
09HumanNon-randomized trialEfficacy outcome
In patients with septic shock, right atrial pressure remained essentially unchanged after methylene blue.
In plain wordsRight heart filling pressure remained essentially unchanged from baseline after methylene blue in patients with septic shock.
Peptide
Methylene blue
Outcome
No significant changeRight atrial pressure
Study
n = 6
Comparator
Baseline
Outcome group
Heart function · Cardiovascular
Studied dose
3 mg kg(-1) · intravenousAs given in this study (human).
Source sentences
Summary
Heart rate, cardiac index, right atrial pressure, DO2, VO2, oxygen extraction and arterial lactate were essentially unchanged.
3 context sentences(design, population, supporting numbers)
Summary · context
A prospective, open, single-dose study.
Summary · context
Six patients with severe septic shock.
Summary · context
Complete hemodynamic values were recorded before and 20 min after the infusion of intravenous MB (3 mg kg(-1)).
Report a problemFND-0875012909
10HumanNon-randomized trialEfficacy outcome
In patients with septic shock, oxygen delivery remained essentially unchanged after methylene blue.
In plain wordsOxygen delivery remained essentially unchanged from baseline after methylene blue in patients with septic shock.
Peptide
Methylene blue
Outcome
No significant changeOxygen delivery
Study
n = 6
Comparator
Baseline
Outcome group
Blood oxygenation and oxygen transport · Whole body
Studied dose
3 mg kg(-1) · intravenousAs given in this study (human).
Source sentences
Summary
Heart rate, cardiac index, right atrial pressure, DO2, VO2, oxygen extraction and arterial lactate were essentially unchanged.
3 context sentences(design, population, supporting numbers)
Summary · context
A prospective, open, single-dose study.
Summary · context
Six patients with severe septic shock.
Summary · context
Complete hemodynamic values were recorded before and 20 min after the infusion of intravenous MB (3 mg kg(-1)).
Report a problemFND-0875012910
11HumanNon-randomized trialEfficacy outcome
In patients with septic shock, oxygen consumption remained essentially unchanged after methylene blue.
In plain wordsOxygen consumption remained essentially unchanged from baseline after methylene blue in patients with septic shock.
Peptide
Methylene blue
Outcome
No significant changeOxygen consumption
Study
n = 6
Comparator
Baseline
Outcome group
Blood oxygenation and oxygen transport · Whole body
Studied dose
3 mg kg(-1) · intravenousAs given in this study (human).
Source sentences
Summary
Heart rate, cardiac index, right atrial pressure, DO2, VO2, oxygen extraction and arterial lactate were essentially unchanged.
3 context sentences(design, population, supporting numbers)
Summary · context
A prospective, open, single-dose study.
Summary · context
Six patients with severe septic shock.
Summary · context
Complete hemodynamic values were recorded before and 20 min after the infusion of intravenous MB (3 mg kg(-1)).
Report a problemFND-0875012911
12HumanNon-randomized trialEfficacy outcome
In patients with septic shock, oxygen extraction remained essentially unchanged after methylene blue.
In plain wordsOxygen extraction remained essentially unchanged from baseline after methylene blue in patients with septic shock.
Peptide
Methylene blue
Outcome
No significant changeOxygen extraction
Study
n = 6
Comparator
Baseline
Outcome group
Blood oxygenation and oxygen transport · Whole body
Studied dose
3 mg kg(-1) · intravenousAs given in this study (human).
Source sentences
Summary
Heart rate, cardiac index, right atrial pressure, DO2, VO2, oxygen extraction and arterial lactate were essentially unchanged.
3 context sentences(design, population, supporting numbers)
Summary · context
A prospective, open, single-dose study.
Summary · context
Six patients with severe septic shock.
Summary · context
Complete hemodynamic values were recorded before and 20 min after the infusion of intravenous MB (3 mg kg(-1)).
Report a problemFND-0875012912
13HumanNon-randomized trialEfficacy outcome
In patients with septic shock, arterial lactate remained essentially unchanged after methylene blue.
In plain wordsArterial lactate remained essentially unchanged from baseline after methylene blue in patients with septic shock.
Peptide
Methylene blue
Outcome
No significant changeArterial lactate
Study
n = 6
Comparator
Baseline
Outcome group
Metabolic pathways and metabolomics · Metabolic and weight
Studied dose
3 mg kg(-1) · intravenousAs given in this study (human).
Source sentences
Summary
Heart rate, cardiac index, right atrial pressure, DO2, VO2, oxygen extraction and arterial lactate were essentially unchanged.
3 context sentences(design, population, supporting numbers)
Summary · context
A prospective, open, single-dose study.
Summary · context
Six patients with severe septic shock.
Summary · context
Complete hemodynamic values were recorded before and 20 min after the infusion of intravenous MB (3 mg kg(-1)).
Report a problemFND-0875012913
14HumanNon-randomized trialEfficacy outcome
In patients with septic shock, arterial pressure returned to baseline in 2-3 h after methylene blue.
In plain wordsBlood pressure returned to baseline after methylene blue in patients with septic shock.
Peptide
Methylene blue
Outcome
Not applicableArterial pressure return to baseline
Study
n = 6
Comparator
Baseline
Outcome group
Blood pressure · Cardiovascular
Studied dose
3 mg kg(-1) · intravenousAs given in this study (human).
Measurements
Time to return to baseline arterial pressure
2 to 3 h
After methylene blue
Source sentences
Summary
Sequential measurements of arterial pressure demonstrated a return to baseline level in 2-3 h.
3 context sentences(design, population, supporting numbers)
Summary · context
A prospective, open, single-dose study.
Summary · context
Six patients with severe septic shock.
Summary · context
Complete hemodynamic values were recorded before and 20 min after the infusion of intravenous MB (3 mg kg(-1)).
Report a problemFND-0875012914
15HumanNon-randomized trialSafety outcome
Among septic shock patients given methylene blue, all but one died, three in shock and two in multiple organ failure.
In plain wordsAll but one septic shock patient given methylene blue died.
Peptide
Methylene blue
Outcome
Not applicableDeaths
Study
n = 6
Outcome group
Mortality · Whole body
Studied dose
3 mg kg(-1) · intravenousAs given in this study (human).
Source sentences
Summary
All but one patients died, three in shock and two in multiple organ failure.
3 context sentences(design, population, supporting numbers)
Summary · context
A prospective, open, single-dose study.
Summary · context
Six patients with severe septic shock.
Summary · context
Complete hemodynamic values were recorded before and 20 min after the infusion of intravenous MB (3 mg kg(-1)).
Report a problemFND-0875012915
16HumanNon-randomized trialSafety outcome
Among septic shock patients given methylene blue, three died in shock.
In plain wordsThree septic shock patients given methylene blue died in shock.
Peptide
Methylene blue
Outcome
Not applicableDeaths in shock
Study
n = 6
Outcome group
Mortality · Whole body
Studied dose
3 mg kg(-1) · intravenousAs given in this study (human).
Measurements
Deaths in shock
3 patients
Septic shock patients given methylene blue
Source sentences
Summary
All but one patients died, three in shock and two in multiple organ failure.
3 context sentences(design, population, supporting numbers)
Summary · context
A prospective, open, single-dose study.
Summary · context
Six patients with severe septic shock.
Summary · context
Complete hemodynamic values were recorded before and 20 min after the infusion of intravenous MB (3 mg kg(-1)).
Report a problemFND-0875012916
17HumanNon-randomized trialSafety outcome
Among septic shock patients given methylene blue, two died in multiple organ failure.
In plain wordsTwo septic shock patients given methylene blue died in multiple organ failure.
Peptide
Methylene blue
Outcome
Not applicableDeaths in multiple organ failure
Study
n = 6
Outcome group
Mortality · Whole body
Studied dose
3 mg kg(-1) · intravenousAs given in this study (human).
Measurements
Deaths in multiple organ failure
2 patients
Septic shock patients given methylene blue
Source sentences
Summary
All but one patients died, three in shock and two in multiple organ failure.
3 context sentences(design, population, supporting numbers)
Summary · context
A prospective, open, single-dose study.
Summary · context
Six patients with severe septic shock.
Summary · context
Complete hemodynamic values were recorded before and 20 min after the infusion of intravenous MB (3 mg kg(-1)).
Report a problemFND-0875012917

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

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