Modulatory effects of gonadorelin on GABA-induced depolarization and GABA-activated current in rat spinal ganglion neurons.

Zhou XP, Wu XP, Guan BC, Li ZW

Zhongguo yao li xue bao = Acta pharmacologica Sinica1 Jan 1996Cited by 1 (Europe PMC)

PMID8737448PepBankPUB-08737448

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

01LabEx vivo tissueMechanism
In rat spinal ganglion neurons, pretreatment with gonadorelin decreased GABA-induced depolarization by 79 +/- 22%.
In plain wordsIn rat nerve cells from spinal ganglia, gonadorelin pretreatment reduced the depolarization caused by GABA.
Peptide
Gonadorelin (GnRH, LHRH)
Outcome
DecreaseGABA-induced depolarization
Study
ratn = 29
spinal ganglion preparation
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
50 mumol.L-1 · superfusion and/or bath applicationAs given in this study (rat).
Measurements
Decrease in GABA-induced depolarization
79%
gonadorelin 50 mumol.L-1
Source sentences
Summary
Pretreatment with gonadorelin (50 mumol.L-1) decreased the GABA-induced depolarization by 79 +/- 22% (n = 29)
1 context sentence(design, population, supporting numbers)
Summary · context
Intracellular recordings and whole-cell patch clamp techniques were performed on neurons in rat spinal ganglia (SG) preparation and neurons freshly isolated from rat SG, respectively.
Report a problemFND-0873744801
02LabEx vivo tissueMechanism
In rat spinal ganglion neurons, gonadorelin alone elicited no effect or slight depolarization.
In plain wordsIn rat nerve cells from spinal ganglia, gonadorelin alone had no effect or caused only slight depolarization.
Peptide
Gonadorelin (GnRH, LHRH)
Outcome
No significant changeGonadorelin alone on membrane potential
Study
ratn: not reported in source
spinal ganglion preparation
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
50 mumol.L-1 · superfusion and/or bath applicationAs given in this study (rat).
Source sentences
Summary
while gonadorelin elicited no effect or slight depolarization alone.
1 context sentence(design, population, supporting numbers)
Summary · context
Intracellular recordings and whole-cell patch clamp techniques were performed on neurons in rat spinal ganglia (SG) preparation and neurons freshly isolated from rat SG, respectively.
Report a problemFND-0873744802
03LabIn vitro (cells)Mechanism
In freshly isolated rat spinal ganglion neurons, gonadorelin pretreatment inhibited GABA-activated currents in 6 of 11 cells, with no change or slight potentiation in 5 of 11.
In plain wordsIn cells from rat spinal ganglia, gonadorelin reduced GABA-activated currents in 6 of 11 cells and left 5 unchanged or slightly increased.
Peptide
Gonadorelin (GnRH, LHRH)
Outcome
MixedGABA-activated current
Study
ratn = 11
freshly isolated spinal ganglion neurons
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
50 mumol.L-1 · superfusion and/or bath applicationAs given in this study (rat).
Source sentences
Summary
In 6 of 11 cells, GABA-activated currents were also inhibited by pretreatment with gonadorelin (50 mumol.L-1), while in 5 of 11 cells, there was no change or a slight potentiation.
1 context sentence(design, population, supporting numbers)
Summary · context
Intracellular recordings and whole-cell patch clamp techniques were performed on neurons in rat spinal ganglia (SG) preparation and neurons freshly isolated from rat SG, respectively.
Report a problemFND-0873744803

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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