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Study · Randomized controlled trial · n = 6 · 1995

4 results

GH responsiveness to repeated GHRH or hexarelin administration in normal adults.

Sartorio A, Conti A, Ferrero S, Spada A, Faglia G

Journal of endocrinological investigation1 Oct 1995Cited by 6 (Europe PMC)

PMID8719303 (opens in a new tab)DOI10.1007/bf03349794 (opens in a new tab)PepBankPUB-08719303
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In normal adults, a first hexarelin bolus released significantly more GH than a first GHRH bolus.

    In plain wordsIn healthy adults, hexarelin released more GH than GHRH did.

    Peptide
    Hexarelin
    Outcome
    IncreaseGH release after a first hexarelin bolus versus GHRH
    Study

    n = 6

    Comparator
    GHRH
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1 microgram/kg · intravenousAs given in this study (human).

    Measurements

    GH nAUC/h
    1424 ng/ml/h
    hexarelin, test c

    Source sentences

    Summary
    Hexarelin administration elicited a marked GH release (test c: 1424 +/- 208.2 ng/ml/h, range: 810.0-2154.0 ng/ml/h), which was significantly higher than those observed after GHRH (vs test a: p < 0.02, vs test b: p < 0.05).
    1 context sentence
    Summary · context
    were evaluated in 6 normal adults.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In normal adults, repeated hexarelin administration significantly reduced the GH response to the second bolus.

    In plain wordsIn healthy adults, a second hexarelin dose two hours later raised GH less than the first dose.

    Peptide
    Hexarelin
    Outcome
    DecreaseGH response to a second hexarelin bolus versus the first
    Study

    n = 6

    Comparator
    First hexarelin bolus
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1 microgram/kg · intravenousAs given in this study (human).

    Measurements

    GH nAUC/h
    286.6 ng/ml/h
    second hexarelin bolus

    Source sentences

    Summary
    Repeated hexarelin administration (test c) was associated with a significant (p < 0.02) reduction of GH responses to the second bolus (286.6 +/- 43.1 ng/ml/h)
    1 context sentence
    Summary · context
    were evaluated in 6 normal adults.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In normal adults, the GH response to a second hexarelin bolus was significantly higher than the response to a second GHRH bolus.

    In plain wordsIn healthy adults, a repeat dose of hexarelin raised GH more than a repeat dose of GHRH.

    Peptide
    Hexarelin
    Outcome
    IncreaseGH response to a second hexarelin bolus versus a second GHRH bolus
    Study

    n = 6

    Comparator
    Second GHRH bolus
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1 microgram/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    which were however significantly higher than those observed after the second GHRH bolus (p < 0.05).
    1 context sentence
    Summary · context
    were evaluated in 6 normal adults.

Studies that did not test the peptide alone1

In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Hexarelin.

  1. 04HumanNot a test of Hexarelin aloneRandomized controlled trialEfficacy outcome

    In normal adults, a hexarelin bolus given after a GHRH bolus caused a clear GH rise in all subjects, while a second GHRH bolus did not sustain GH levels.

    In plain wordsIn healthy adults, hexarelin given after GHRH raised GH again, while a second GHRH dose did not.

    Peptide
    Hexarelin
    Outcome
    IncreaseGH rise to hexarelin given after GHRH versus a second GHRH bolus
    Study

    n = 6

    Comparator
    Second GHRH bolus
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Measurements

    GH nAUC/h
    1049.7 ng/ml/h
    hexarelin after GHRH, test b
    GH nAUC
    74.5 ng/ml/h
    second GHRH bolus, test a

    Source sentences

    Summary
    After the first GHRH bolus, the second GHRH injection (test a) was unable to sustain GH elevated levels (mean GH nAUC: 74.5 +/- 26.5 ng/ml/h, range: 9.7-182.2 ng/ml/h), while hexarelin administration (test b) caused a clear GH rise in all subjects (GH nAUC: 1049.7 +/- 105.2 ng/ml/h, range: 786.0-1356.0 ng/ml/h).
    1 context sentence
    Summary · context
    were evaluated in 6 normal adults.

    In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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