DDAVP reduces bleeding during continued hirudin administration in the rabbit.

Bove CM, Casey B, Marder VJ

Thrombosis and haemostasis1 Mar 1996Cited by 23 (Europe PMC)

PMID8701410DOI10.1055/s-0038-1650299PepBankPUB-08701410

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rabbits receiving hirudin, DDAVP reduced mean primary bleeding duration from 10.8 to 5.9 min (p = 0.001).
In plain wordsIn rabbits receiving hirudin, DDAVP shortened primary bleeding compared with saline.
Peptide
Desmopressin
Outcome
DecreasePrimary bleeding duration
Study
rabbitn: not reported in source
Hirudin-induced hemorrhage
Comparator
Saline during hirudin infusion
Outcome group
Bleeding and clotting · Whole body
Studied dose
Dose not stated · intravenous · 15-min infusionAs given in this study (rabbit).
Source sentences
Summary
DDAVP reduced the mean duration of primary bleeding from 10.8 min to 5.9 min (p = 0.001) as well as the number of sites which bled for longer than 6 or 20 min (46% vs 27%, p = 0.002; and 18% vs 5%, p = 0.002, respectively).
1 context sentence(design, population, supporting numbers)
Summary · context
In a randomized and blinded manner, rabbits were exposed to a 15-min intravenous infusion of DDAVP or saline midway through a continuous two-h intravenous infusion of hirudin.
Report a problemFND-0870141001
02AnimalAnimal study (in vivo)Efficacy outcome
In rabbits receiving hirudin, DDAVP reduced sites bleeding longer than 6 min from 46% to 27% (p = 0.002).
In plain wordsIn rabbits receiving hirudin, fewer sites bled longer than 6 min with DDAVP than with saline.
Peptide
Desmopressin
Outcome
DecreaseSites bleeding longer than 6 min
Study
rabbitn: not reported in source
Hirudin-induced hemorrhage
Comparator
Saline during hirudin infusion
Outcome group
Bleeding and clotting · Whole body
Studied dose
Dose not stated · intravenous · 15-min infusionAs given in this study (rabbit).
Source sentences
Summary
DDAVP reduced the mean duration of primary bleeding from 10.8 min to 5.9 min (p = 0.001) as well as the number of sites which bled for longer than 6 or 20 min (46% vs 27%, p = 0.002; and 18% vs 5%, p = 0.002, respectively).
1 context sentence(design, population, supporting numbers)
Summary · context
In a randomized and blinded manner, rabbits were exposed to a 15-min intravenous infusion of DDAVP or saline midway through a continuous two-h intravenous infusion of hirudin.
Report a problemFND-0870141002
03AnimalAnimal study (in vivo)Efficacy outcome
In rabbits receiving hirudin, DDAVP reduced sites bleeding longer than 20 min from 18% to 5% (p = 0.002).
In plain wordsIn rabbits receiving hirudin, fewer sites bled longer than 20 min with DDAVP than with saline.
Peptide
Desmopressin
Outcome
DecreaseSites bleeding longer than 20 min
Study
rabbitn: not reported in source
Hirudin-induced hemorrhage
Comparator
Saline during hirudin infusion
Outcome group
Bleeding and clotting · Whole body
Studied dose
Dose not stated · intravenous · 15-min infusionAs given in this study (rabbit).
Source sentences
Summary
DDAVP reduced the mean duration of primary bleeding from 10.8 min to 5.9 min (p = 0.001) as well as the number of sites which bled for longer than 6 or 20 min (46% vs 27%, p = 0.002; and 18% vs 5%, p = 0.002, respectively).
1 context sentence(design, population, supporting numbers)
Summary · context
In a randomized and blinded manner, rabbits were exposed to a 15-min intravenous infusion of DDAVP or saline midway through a continuous two-h intravenous infusion of hirudin.
Report a problemFND-0870141003
04AnimalAnimal study (in vivo)Efficacy outcome
In rabbits receiving hirudin, spontaneous rebleeding incidence did not differ between DDAVP and saline (reported rates 44% and 36%, p = 0.21).
In plain wordsIn rabbits receiving hirudin, rebleeding incidence did not differ between DDAVP and saline.
Peptide
Desmopressin
Outcome
No significant changeSpontaneous rebleeding incidence
Study
rabbitn: not reported in source
Hirudin-induced hemorrhage
Comparator
Saline during hirudin infusion
Outcome group
Bleeding and clotting · Whole body
Studied dose
Dose not stated · intravenous · 15-min infusionAs given in this study (rabbit).
Source sentences
Summary
Although there was no difference in the incidence of spontaneous rebleeding from these sites (44 vs 36%, p = 0.21), rebleeding did not persist as long in animals that received DDAVP (8 vs 16 min, p = 0.005), and fewer sites rebled for longer than 20 min (8 vs 27%, p = 0.027).
1 context sentence(design, population, supporting numbers)
Summary · context
In a randomized and blinded manner, rabbits were exposed to a 15-min intravenous infusion of DDAVP or saline midway through a continuous two-h intravenous infusion of hirudin.
Report a problemFND-0870141004
05AnimalAnimal study (in vivo)Efficacy outcome
In rabbits receiving hirudin, rebleeding lasted 8 min with DDAVP versus 16 min with saline (p = 0.005).
In plain wordsIn rabbits receiving hirudin, rebleeding was shorter with DDAVP than with saline.
Peptide
Desmopressin
Outcome
DecreaseRebleeding duration
Study
rabbitn: not reported in source
Hirudin-induced hemorrhage
Comparator
Saline during hirudin infusion
Outcome group
Bleeding and clotting · Whole body
Studied dose
Dose not stated · intravenous · 15-min infusionAs given in this study (rabbit).
Source sentences
Summary
Although there was no difference in the incidence of spontaneous rebleeding from these sites (44 vs 36%, p = 0.21), rebleeding did not persist as long in animals that received DDAVP (8 vs 16 min, p = 0.005), and fewer sites rebled for longer than 20 min (8 vs 27%, p = 0.027).
1 context sentence(design, population, supporting numbers)
Summary · context
In a randomized and blinded manner, rabbits were exposed to a 15-min intravenous infusion of DDAVP or saline midway through a continuous two-h intravenous infusion of hirudin.
Report a problemFND-0870141005
06AnimalAnimal study (in vivo)Efficacy outcome
In rabbits receiving hirudin, fewer sites rebled longer than 20 min with DDAVP (8 vs 27%, p = 0.027).
In plain wordsIn rabbits receiving hirudin, fewer sites rebled longer than 20 min with DDAVP than with saline.
Peptide
Desmopressin
Outcome
DecreaseSites rebleeding longer than 20 min
Study
rabbitn: not reported in source
Hirudin-induced hemorrhage
Comparator
Saline during hirudin infusion
Outcome group
Bleeding and clotting · Whole body
Studied dose
Dose not stated · intravenous · 15-min infusionAs given in this study (rabbit).
Source sentences
Summary
Although there was no difference in the incidence of spontaneous rebleeding from these sites (44 vs 36%, p = 0.21), rebleeding did not persist as long in animals that received DDAVP (8 vs 16 min, p = 0.005), and fewer sites rebled for longer than 20 min (8 vs 27%, p = 0.027).
1 context sentence(design, population, supporting numbers)
Summary · context
In a randomized and blinded manner, rabbits were exposed to a 15-min intravenous infusion of DDAVP or saline midway through a continuous two-h intravenous infusion of hirudin.
Report a problemFND-0870141006

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:35 UTC
First added · source update from Europe PMC

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