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Study · Non-randomized trial · n = 7 · 1996

2 results

Effects of xylitol on urea synthesis in normal humans: relation to glucagon.

Hamberg O, Almdal TP

JPEN. Journal of parenteral and enteral nutrition1 Mar 1996Cited by 6 (Europe PMC)

PMID8676533 (opens in a new tab)DOI10.1177/0148607196020002139 (opens in a new tab)PepBankPUB-08676533
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanNon-randomized trialPharmacokinetics

    In healthy subjects, glucagon infusion increased plasma glucagon versus alanine infusion alone.

    In plain wordsIn healthy subjects, glucagon infusion raised blood glucagon compared with alanine infusion alone.

    Peptide
    Glucagon
    Outcome
    IncreasePlasma glucagon
    Study

    n = 7

    Comparator
    Alanine infusion alone
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Glucagon infusion increased plasma glucagon to -450 ng/L and FHNC twofold to 50.9 +/- 6.2 L/h
    1 context sentence
    Summary · context
    FHNC was measured on four separate occasions in each of seven healthy subjects: during constant infusion of alanine alone, alanine superimposed on a constant infusion of xylitol (blood xylitol 1 mmol/L), alanine superimposed on infusion of glucagon, and alanine superimposed on infusions of xylitol and glucagon.
  2. 02HumanNon-randomized trialMechanism

    In healthy subjects, glucagon infusion doubled functional hepatic nitrogen clearance to 50.9 +/- 6.2 L/h versus alanine infusion alone.

    In plain wordsIn healthy subjects, glucagon doubled liver nitrogen clearance compared with alanine infusion alone.

    Peptide
    Glucagon
    Outcome
    IncreaseFunctional hepatic nitrogen clearance
    Study

    n = 7

    Comparator
    Alanine infusion alone
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated

    Measurements

    FHNC
    50.9 L/h
    glucagon; +/- 6.2
    FHNC
    27.9 L/h
    alanine alone; +/- 1.3

    Source sentences

    Summary
    Glucagon infusion increased plasma glucagon to -450 ng/L and FHNC twofold to 50.9 +/- 6.2 L/h
    2 context sentences
    Summary · context
    During alanine infusion alone, plasma glucagon rose to -170 ng/L, and FHNC was (mean +/- sem) 27.9 +/- 1.3 L/h.
    Summary · context
    FHNC was measured on four separate occasions in each of seven healthy subjects: during constant infusion of alanine alone, alanine superimposed on a constant infusion of xylitol (blood xylitol 1 mmol/L), alanine superimposed on infusion of glucagon, and alanine superimposed on infusions of xylitol and glucagon.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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