In children with nocturnal enuresis, desmopressin plus alarm produced 6.3 dry nights weekly versus 4.8 with alarm alone, a significant difference.
In plain wordsIn children with nocturnal enuresis, desmopressin plus alarm increased dry nights compared with alarm alone.
- Peptide
- Desmopressin
- Outcome
- IncreaseDry nights per week
- Study
n = 71
- Comparator
- Enuresis alarm alone
- Outcome group
- Urinary continence and bladder function · Kidney and urinary
- Studied dose
- 40 micrograms · intranasal · up to 6 weeksAs given in this study (human).
Measurements
- Mean dry nights per week
- 6.3 nights per week
- alarm and desmopressin group
- Mean dry nights per week
- 4.8 nights per week
- alarm group
Source sentences
At the end of treatment there was a significant difference in the mean number of dry nights per week between the two groups (6.3 in the alarm and desmopressin group and 4.8 in the alarm group) and also in the number of children becoming reliably dry.
4 context sentences(design, population, supporting numbers)
Seventy-one children with nocturnal enuresis were enrolled in a controlled trial.
The children were allocated to two matched groups.
Children in both groups used an enuresis alarm until the end of treatment.
Children in the first group were treated with 40 micrograms of intranasal desmopressin (Desmospray) for up to 6 weeks at the start of treatment with the alarm.