In control and mutant mice, GHRP‑6 induced marked c-fos mRNA expression in the arcuate-ventromedial hypothalamus.
In plain wordsIn control and mutant mice, GHRP‑6 increased c-fos mRNA expression in the arcuate-ventromedial hypothalamus.
- Peptide
- GHRP-6
- Outcome
- IncreaseHypothalamic c-fos mRNA expression
- Study
mousen: not reported in source
Wild-type, dwarf and little mutant mice- Outcome group
- Receptor activity and mechanism · Nervous system and cognition
- Studied dose
- Dose not stated · systemic injectionAs given in this study (mouse).
Source sentences
Both GH secretagogues induced a marked c-fos mRNA expression in the arcuate-ventromedial hypothalamus (ARC-VMH) of both control and mutant mice indicating a possible action on growth hormone releasing hormone (GHRH) neurones in the ARC-VMH.
1 context sentence(design, population, supporting numbers)
We have studied by in situ hybridization histochemistry the mRNA expression of the c-fos immediate early gene in the brains of wild type and dwarf(dw/dw) and little(lit/lit) mutant mice after systemic injections of the synthetic GH secretagogues GHRP-6 and L-163,191.