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Study · Randomized controlled trial · n = 6 · 1995

4 results

Hexarelin induced growth hormone release is influenced by exogenous growth hormone.

Massoud AF, Hindmarsh PC, Brook CG

Clinical endocrinology1 Nov 1995Cited by 17 (Europe PMC)

PMID8548947 (opens in a new tab)DOI10.1111/j.1365-2265.1995.tb02927.x (opens in a new tab)PepBankPUB-08548947
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In healthy men given saline first, the peak GH response to hexarelin was greater than the response to GHRH.

    In plain wordsIn healthy men, hexarelin raised peak GH more than GHRH did.

    Peptide
    Hexarelin
    Outcome
    IncreasePeak GH to hexarelin versus GHRH after saline
    Study

    n = 6

    Comparator
    GHRH
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated · intravenousAs given in this study (human).

    Source sentences

    Summary
    The peak serum GH response to hexarelin was greater than that to GHRH, irrespective of whether the first bolus was saline (P < 0.05) or rhGH (P < 0.02).
    2 context sentences
    Summary · context
    Six healthy adult males (23.8-34.3 years) were studied.
    Summary · context
    Boluses of saline or rhGH were administered intravenously, followed 90 minutes later by a second intravenous bolus of saline, hexarelin or GHRH.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In healthy men given rhGH first, the peak GH response to hexarelin was greater than the response to GHRH.

    In plain wordsIn healthy men who first received growth hormone, hexarelin still raised peak GH more than GHRH did.

    Peptide
    Hexarelin
    Outcome
    IncreasePeak GH to hexarelin versus GHRH after rhGH
    Study

    n = 6

    Comparator
    GHRH
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated · intravenousAs given in this study (human).

    Source sentences

    Summary
    The peak serum GH response to hexarelin was greater than that to GHRH, irrespective of whether the first bolus was saline (P < 0.05) or rhGH (P < 0.02).
    2 context sentences
    Summary · context
    Six healthy adult males (23.8-34.3 years) were studied.
    Summary · context
    Boluses of saline or rhGH were administered intravenously, followed 90 minutes later by a second intravenous bolus of saline, hexarelin or GHRH.

Studies that did not test the peptide alone2

In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Hexarelin.

  1. 03HumanNot a test of Hexarelin aloneRandomized controlled trialEfficacy outcome

    In healthy men, prior administration of rhGH reduced the peak serum GH response to hexarelin.

    In plain wordsIn healthy men, growth hormone given beforehand reduced the GH rise caused by hexarelin.

    Peptide
    Hexarelin
    Outcome
    DecreaseEffect of prior rhGH on the peak GH response to hexarelin
    Study

    n = 6

    Comparator
    Saline before hexarelin
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    Prior administration of rhGH led to a reduction in peak serum GH response to hexarelin or GHRH (P < 0.05)
    2 context sentences
    Summary · context
    Six healthy adult males (23.8-34.3 years) were studied.
    Summary · context
    Boluses of saline or rhGH were administered intravenously, followed 90 minutes later by a second intravenous bolus of saline, hexarelin or GHRH.

    In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.

  2. 04HumanNot a test of Hexarelin aloneRandomized controlled trialEfficacy outcome

    In healthy men, the percentage reduction by prior rhGH was smaller for hexarelin than for GHRH, but the difference was not statistically significant.

    In plain wordsIn healthy men, growth hormone beforehand cut the hexarelin response a little less than the GHRH response, but this difference was not significant.

    Peptide
    Hexarelin
    Outcome
    No significant changeReduction in GH response after rhGH, hexarelin versus GHRH
    Study

    n = 6

    Comparator
    GHRH
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    the percentage reduction in response to hexarelin was less than that to GHRH, but this difference was not statistically significant (P = 0.3).
    2 context sentences
    Summary · context
    Six healthy adult males (23.8-34.3 years) were studied.
    Summary · context
    Boluses of saline or rhGH were administered intravenously, followed 90 minutes later by a second intravenous bolus of saline, hexarelin or GHRH.

    In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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