Induction of pre-ovulatory gonadotrophin surge with gonadotrophin-releasing hormone agonist compared to pre-ovulatory injection of human chorionic gonadotrophins for ovulation induction in intrauterine insemination treatment cycles.

Shalev E, Geslevich Y, Matilsky M, Ben-Ami M

Human reproduction (Oxford, England)1 Sept 1995Cited by 16 (Europe PMC)

PMID8530644DOI10.1093/oxfordjournals.humrep.a136277PepBankPUB-08530644

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. 6 results from people.

01HumanRandomized controlled trialActivity measurement
In women undergoing IUI, triptorelin produced a transient increase in serum luteinizing hormone.
In plain wordsIn women undergoing insemination, triptorelin briefly increased luteinizing hormone levels.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseLuteinizing hormone surge
Study
n = 24
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
0.1 mg · subcutaneous · single injectionAs given in this study (human).
Source sentences
Summary
A transitory increase in serum luteinizing hormone and follicle stimulating hormone concentrations was achieved following injection of GnRHa.
2 context sentences(design, population, supporting numbers)
Summary · context
A group of 48 patients presenting with amenorrhoea, oligomenorrhoea or unexplained infertility were all treated with human menopausal gonadotrophins (HMG) from day 5 of the cycle, on an individualized schedule.
Summary · context
They were then randomly divided into two groups to receive either a single s.c. injection of 0.1 mg triptorelin or a single i.m. injection of 10,000 IU HCG after follicular maturation.
Report a problemFND-0853064401
02HumanRandomized controlled trialActivity measurement
In women undergoing IUI, triptorelin produced a transient increase in serum follicle stimulating hormone.
In plain wordsIn women undergoing insemination, triptorelin briefly increased follicle stimulating hormone levels.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseFollicle stimulating hormone surge
Study
n = 24
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
0.1 mg · subcutaneous · single injectionAs given in this study (human).
Source sentences
Summary
A transitory increase in serum luteinizing hormone and follicle stimulating hormone concentrations was achieved following injection of GnRHa.
2 context sentences(design, population, supporting numbers)
Summary · context
A group of 48 patients presenting with amenorrhoea, oligomenorrhoea or unexplained infertility were all treated with human menopausal gonadotrophins (HMG) from day 5 of the cycle, on an individualized schedule.
Summary · context
They were then randomly divided into two groups to receive either a single s.c. injection of 0.1 mg triptorelin or a single i.m. injection of 10,000 IU HCG after follicular maturation.
Report a problemFND-0853064402
03HumanRandomized controlled trialEfficacy outcome
In women receiving triptorelin for IUI, 72 treatment cycles produced 11 conceptions, a rate of 15.3%.
In plain wordsIn women receiving triptorelin for insemination, the conception rate was 15.3% per treatment cycle.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
Not applicableConceptions
Study
n = 24
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
0.1 mg · subcutaneous · single injectionAs given in this study (human).
Measurements
Conceptions
11 conceptions
72 treatment cycles
Conception rate
15.3%
triptorelin cycles
Source sentences
Summary
A total of 24 patients received 72 treatment cycles with GnRHa, producing 11 conceptions (15.3%) and two abortions (18.2%), resulting in a term pregnancy rate of 13.6%.
2 context sentences(design, population, supporting numbers)
Summary · context
A group of 48 patients presenting with amenorrhoea, oligomenorrhoea or unexplained infertility were all treated with human menopausal gonadotrophins (HMG) from day 5 of the cycle, on an individualized schedule.
Summary · context
They were then randomly divided into two groups to receive either a single s.c. injection of 0.1 mg triptorelin or a single i.m. injection of 10,000 IU HCG after follicular maturation.
Report a problemFND-0853064403
04HumanRandomized controlled trialEfficacy outcome
In women receiving triptorelin for IUI, the term pregnancy rate was 13.6%.
In plain wordsIn women receiving triptorelin for insemination, the term pregnancy rate was 13.6%.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
Not applicableTerm pregnancy rate
Study
n = 24
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
0.1 mg · subcutaneous · single injectionAs given in this study (human).
Measurements
Term pregnancy rate
13.6%
triptorelin
Source sentences
Summary
A total of 24 patients received 72 treatment cycles with GnRHa, producing 11 conceptions (15.3%) and two abortions (18.2%), resulting in a term pregnancy rate of 13.6%.
2 context sentences(design, population, supporting numbers)
Summary · context
A group of 48 patients presenting with amenorrhoea, oligomenorrhoea or unexplained infertility were all treated with human menopausal gonadotrophins (HMG) from day 5 of the cycle, on an individualized schedule.
Summary · context
They were then randomly divided into two groups to receive either a single s.c. injection of 0.1 mg triptorelin or a single i.m. injection of 10,000 IU HCG after follicular maturation.
Report a problemFND-0853064405
05HumanRandomized controlled trialSafety outcome
In women receiving triptorelin for IUI, four grade 3-4 ovarian hyperstimulation cases occurred, including two conception cycles.
In plain wordsIn women receiving triptorelin for insemination, four severe ovarian hyperstimulation cases occurred, including two conception cycles.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
Not applicableGrade 3-4 ovarian hyperstimulation syndrome
Study
n = 24
Outcome group
Adverse events · Reproductive and sexual health
Studied dose
0.1 mg · subcutaneous · single injectionAs given in this study (human).
Measurements
OHSS cases
4 cases
grade 3-4
OHSS conception cycles
2 cycles
triptorelin
Source sentences
Summary
There were four cases of grade 3-4 ovarian hyperstimulation syndrome (OHSS), two of which were conception cycles.
2 context sentences(design, population, supporting numbers)
Summary · context
A group of 48 patients presenting with amenorrhoea, oligomenorrhoea or unexplained infertility were all treated with human menopausal gonadotrophins (HMG) from day 5 of the cycle, on an individualized schedule.
Summary · context
They were then randomly divided into two groups to receive either a single s.c. injection of 0.1 mg triptorelin or a single i.m. injection of 10,000 IU HCG after follicular maturation.
Report a problemFND-0853064406
06HumanRandomized controlled trialSafety outcome
In women receiving triptorelin for IUI, two abortions occurred, a rate of 18.2% of conceptions.
In plain wordsIn women receiving triptorelin for insemination, two abortions occurred among the conceptions.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
Not applicableAbortions
Study
n: not reported in source
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
0.1 mg · subcutaneous · single injectionAs given in this study (human).
Measurements
Abortions
2 abortions
triptorelin
Abortion rate
18.2%
conceptions
Source sentences
Summary
A total of 24 patients received 72 treatment cycles with GnRHa, producing 11 conceptions (15.3%) and two abortions (18.2%), resulting in a term pregnancy rate of 13.6%.
2 context sentences(design, population, supporting numbers)
Summary · context
A group of 48 patients presenting with amenorrhoea, oligomenorrhoea or unexplained infertility were all treated with human menopausal gonadotrophins (HMG) from day 5 of the cycle, on an individualized schedule.
Summary · context
They were then randomly divided into two groups to receive either a single s.c. injection of 0.1 mg triptorelin or a single i.m. injection of 10,000 IU HCG after follicular maturation.
Report a problemFND-0853064404

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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