Comparison of Wilkins-Chalgren medium supplemented with nicotinamide adenine dinucleotide and Haemophilus test medium for susceptibility testing of clinical Haemophilus isolates.

Traub WH, Leonhard B

Chemotherapy1 Nov 1995

PMID8529434DOI10.1159/000239380PepBankPUB-08529434

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone11

In this study, NAD+ (nicotinamide adenine dinucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking NAD+ (nicotinamide adenine dinucleotide).

01LabNot a test of NAD+ (nicotinamide adenine dinucleotide) aloneIn vitro (cells)Activity measurement
In clinical Haemophilus isolates, NAD-supplemented Wilkins-Chalgren agar and Haemophilus test medium yielded comparable ampicillin susceptibility results.
In plain wordsIn lab tests, NAD-supplemented agar and Haemophilus test medium gave comparable ampicillin susceptibility results.
Peptide
NAD+ (nicotinamide adenine dinucleotide)
Outcome
No significant changeAmpicillin susceptibility testing
Study
Haemophilus influenzae; Haemophilus parainfluenzaen = 74
Clinical Haemophilus isolates on supplemented Wilkins-Chalgren agar
Comparator
Haemophilus test medium
Outcome group
Infection and antimicrobial activity · Infection
Source sentences
Summary
WCA + NAD and HTM yielded comparable results for the following antimicrobial drugs and drug combinations: ampicillin, amoxicillin plus clavulanic acid, ampicillin plus sulbactam, cefotaxime, cefuroxime, chloramphenicol, ciprofloxacin, and doxycycline.
2 context sentences(design, population, supporting numbers)
Summary · context
Haemophilus test medium (HTM) was compared with Wilkins-Chalgren agar (WCA; supplemented with 15 micrograms/ml nicotinamide adenine dinucleotide (NAD)) for antibiotic susceptibility testing of 74 clinical isolates of Haemophilus influenzae and Haemophilus parainfluenzae.
Summary · context
The Bauer-Kirby agar disk diffusion method and the agar dilution procedure were the two tests employed.
In this study, NAD+ (nicotinamide adenine dinucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NAD+ (nicotinamide adenine dinucleotide).
Report a problemFND-0852943401
02LabNot a test of NAD+ (nicotinamide adenine dinucleotide) aloneIn vitro (cells)Activity measurement
In clinical Haemophilus isolates, NAD-supplemented Wilkins-Chalgren agar and Haemophilus test medium yielded comparable amoxicillin plus clavulanic acid susceptibility results.
In plain wordsIn lab tests, NAD-supplemented agar and Haemophilus test medium gave comparable amoxicillin plus clavulanic acid susceptibility results.
Peptide
NAD+ (nicotinamide adenine dinucleotide)
Outcome
No significant changeAmoxicillin plus clavulanic acid susceptibility testing
Study
Haemophilus influenzae; Haemophilus parainfluenzaen = 74
Clinical Haemophilus isolates on supplemented Wilkins-Chalgren agar
Comparator
Haemophilus test medium
Outcome group
Infection and antimicrobial activity · Infection
Source sentences
Summary
WCA + NAD and HTM yielded comparable results for the following antimicrobial drugs and drug combinations: ampicillin, amoxicillin plus clavulanic acid, ampicillin plus sulbactam, cefotaxime, cefuroxime, chloramphenicol, ciprofloxacin, and doxycycline.
2 context sentences(design, population, supporting numbers)
Summary · context
Haemophilus test medium (HTM) was compared with Wilkins-Chalgren agar (WCA; supplemented with 15 micrograms/ml nicotinamide adenine dinucleotide (NAD)) for antibiotic susceptibility testing of 74 clinical isolates of Haemophilus influenzae and Haemophilus parainfluenzae.
Summary · context
The Bauer-Kirby agar disk diffusion method and the agar dilution procedure were the two tests employed.
In this study, NAD+ (nicotinamide adenine dinucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NAD+ (nicotinamide adenine dinucleotide).
Report a problemFND-0852943402
03LabNot a test of NAD+ (nicotinamide adenine dinucleotide) aloneIn vitro (cells)Activity measurement
In clinical Haemophilus isolates, NAD-supplemented Wilkins-Chalgren agar and Haemophilus test medium yielded comparable ampicillin plus sulbactam susceptibility results.
In plain wordsIn lab tests, NAD-supplemented agar and Haemophilus test medium gave comparable ampicillin plus sulbactam susceptibility results.
Peptide
NAD+ (nicotinamide adenine dinucleotide)
Outcome
No significant changeAmpicillin plus sulbactam susceptibility testing
Study
Haemophilus influenzae; Haemophilus parainfluenzaen = 74
Clinical Haemophilus isolates on supplemented Wilkins-Chalgren agar
Comparator
Haemophilus test medium
Outcome group
Infection and antimicrobial activity · Infection
Source sentences
Summary
WCA + NAD and HTM yielded comparable results for the following antimicrobial drugs and drug combinations: ampicillin, amoxicillin plus clavulanic acid, ampicillin plus sulbactam, cefotaxime, cefuroxime, chloramphenicol, ciprofloxacin, and doxycycline.
2 context sentences(design, population, supporting numbers)
Summary · context
Haemophilus test medium (HTM) was compared with Wilkins-Chalgren agar (WCA; supplemented with 15 micrograms/ml nicotinamide adenine dinucleotide (NAD)) for antibiotic susceptibility testing of 74 clinical isolates of Haemophilus influenzae and Haemophilus parainfluenzae.
Summary · context
The Bauer-Kirby agar disk diffusion method and the agar dilution procedure were the two tests employed.
In this study, NAD+ (nicotinamide adenine dinucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NAD+ (nicotinamide adenine dinucleotide).
Report a problemFND-0852943403
04LabNot a test of NAD+ (nicotinamide adenine dinucleotide) aloneIn vitro (cells)Activity measurement
In clinical Haemophilus isolates, NAD-supplemented Wilkins-Chalgren agar and Haemophilus test medium yielded comparable cefotaxime susceptibility results.
In plain wordsIn lab tests, NAD-supplemented agar and Haemophilus test medium gave comparable cefotaxime susceptibility results.
Peptide
NAD+ (nicotinamide adenine dinucleotide)
Outcome
No significant changeCefotaxime susceptibility testing
Study
Haemophilus influenzae; Haemophilus parainfluenzaen = 74
Clinical Haemophilus isolates on supplemented Wilkins-Chalgren agar
Comparator
Haemophilus test medium
Outcome group
Infection and antimicrobial activity · Infection
Source sentences
Summary
WCA + NAD and HTM yielded comparable results for the following antimicrobial drugs and drug combinations: ampicillin, amoxicillin plus clavulanic acid, ampicillin plus sulbactam, cefotaxime, cefuroxime, chloramphenicol, ciprofloxacin, and doxycycline.
2 context sentences(design, population, supporting numbers)
Summary · context
Haemophilus test medium (HTM) was compared with Wilkins-Chalgren agar (WCA; supplemented with 15 micrograms/ml nicotinamide adenine dinucleotide (NAD)) for antibiotic susceptibility testing of 74 clinical isolates of Haemophilus influenzae and Haemophilus parainfluenzae.
Summary · context
The Bauer-Kirby agar disk diffusion method and the agar dilution procedure were the two tests employed.
In this study, NAD+ (nicotinamide adenine dinucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NAD+ (nicotinamide adenine dinucleotide).
Report a problemFND-0852943404
05LabNot a test of NAD+ (nicotinamide adenine dinucleotide) aloneIn vitro (cells)Activity measurement
In clinical Haemophilus isolates, NAD-supplemented Wilkins-Chalgren agar and Haemophilus test medium yielded comparable cefuroxime susceptibility results.
In plain wordsIn lab tests, NAD-supplemented agar and Haemophilus test medium gave comparable cefuroxime susceptibility results.
Peptide
NAD+ (nicotinamide adenine dinucleotide)
Outcome
No significant changeCefuroxime susceptibility testing
Study
Haemophilus influenzae; Haemophilus parainfluenzaen = 74
Clinical Haemophilus isolates on supplemented Wilkins-Chalgren agar
Comparator
Haemophilus test medium
Outcome group
Infection and antimicrobial activity · Infection
Source sentences
Summary
WCA + NAD and HTM yielded comparable results for the following antimicrobial drugs and drug combinations: ampicillin, amoxicillin plus clavulanic acid, ampicillin plus sulbactam, cefotaxime, cefuroxime, chloramphenicol, ciprofloxacin, and doxycycline.
2 context sentences(design, population, supporting numbers)
Summary · context
Haemophilus test medium (HTM) was compared with Wilkins-Chalgren agar (WCA; supplemented with 15 micrograms/ml nicotinamide adenine dinucleotide (NAD)) for antibiotic susceptibility testing of 74 clinical isolates of Haemophilus influenzae and Haemophilus parainfluenzae.
Summary · context
The Bauer-Kirby agar disk diffusion method and the agar dilution procedure were the two tests employed.
In this study, NAD+ (nicotinamide adenine dinucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NAD+ (nicotinamide adenine dinucleotide).
Report a problemFND-0852943405
06LabNot a test of NAD+ (nicotinamide adenine dinucleotide) aloneIn vitro (cells)Activity measurement
In clinical Haemophilus isolates, NAD-supplemented Wilkins-Chalgren agar and Haemophilus test medium yielded comparable chloramphenicol susceptibility results.
In plain wordsIn lab tests, NAD-supplemented agar and Haemophilus test medium gave comparable chloramphenicol susceptibility results.
Peptide
NAD+ (nicotinamide adenine dinucleotide)
Outcome
No significant changeChloramphenicol susceptibility testing
Study
Haemophilus influenzae; Haemophilus parainfluenzaen = 74
Clinical Haemophilus isolates on supplemented Wilkins-Chalgren agar
Comparator
Haemophilus test medium
Outcome group
Infection and antimicrobial activity · Infection
Source sentences
Summary
WCA + NAD and HTM yielded comparable results for the following antimicrobial drugs and drug combinations: ampicillin, amoxicillin plus clavulanic acid, ampicillin plus sulbactam, cefotaxime, cefuroxime, chloramphenicol, ciprofloxacin, and doxycycline.
2 context sentences(design, population, supporting numbers)
Summary · context
Haemophilus test medium (HTM) was compared with Wilkins-Chalgren agar (WCA; supplemented with 15 micrograms/ml nicotinamide adenine dinucleotide (NAD)) for antibiotic susceptibility testing of 74 clinical isolates of Haemophilus influenzae and Haemophilus parainfluenzae.
Summary · context
The Bauer-Kirby agar disk diffusion method and the agar dilution procedure were the two tests employed.
In this study, NAD+ (nicotinamide adenine dinucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NAD+ (nicotinamide adenine dinucleotide).
Report a problemFND-0852943406
07LabNot a test of NAD+ (nicotinamide adenine dinucleotide) aloneIn vitro (cells)Activity measurement
In clinical Haemophilus isolates, NAD-supplemented Wilkins-Chalgren agar and Haemophilus test medium yielded comparable ciprofloxacin susceptibility results.
In plain wordsIn lab tests, NAD-supplemented agar and Haemophilus test medium gave comparable ciprofloxacin susceptibility results.
Peptide
NAD+ (nicotinamide adenine dinucleotide)
Outcome
No significant changeCiprofloxacin susceptibility testing
Study
Haemophilus influenzae; Haemophilus parainfluenzaen = 74
Clinical Haemophilus isolates on supplemented Wilkins-Chalgren agar
Comparator
Haemophilus test medium
Outcome group
Infection and antimicrobial activity · Infection
Source sentences
Summary
WCA + NAD and HTM yielded comparable results for the following antimicrobial drugs and drug combinations: ampicillin, amoxicillin plus clavulanic acid, ampicillin plus sulbactam, cefotaxime, cefuroxime, chloramphenicol, ciprofloxacin, and doxycycline.
2 context sentences(design, population, supporting numbers)
Summary · context
Haemophilus test medium (HTM) was compared with Wilkins-Chalgren agar (WCA; supplemented with 15 micrograms/ml nicotinamide adenine dinucleotide (NAD)) for antibiotic susceptibility testing of 74 clinical isolates of Haemophilus influenzae and Haemophilus parainfluenzae.
Summary · context
The Bauer-Kirby agar disk diffusion method and the agar dilution procedure were the two tests employed.
In this study, NAD+ (nicotinamide adenine dinucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NAD+ (nicotinamide adenine dinucleotide).
Report a problemFND-0852943407
08LabNot a test of NAD+ (nicotinamide adenine dinucleotide) aloneIn vitro (cells)Activity measurement
In clinical Haemophilus isolates, NAD-supplemented Wilkins-Chalgren agar and Haemophilus test medium yielded comparable doxycycline susceptibility results.
In plain wordsIn lab tests, NAD-supplemented agar and Haemophilus test medium gave comparable doxycycline susceptibility results.
Peptide
NAD+ (nicotinamide adenine dinucleotide)
Outcome
No significant changeDoxycycline susceptibility testing
Study
Haemophilus influenzae; Haemophilus parainfluenzaen = 74
Clinical Haemophilus isolates on supplemented Wilkins-Chalgren agar
Comparator
Haemophilus test medium
Outcome group
Infection and antimicrobial activity · Infection
Source sentences
Summary
WCA + NAD and HTM yielded comparable results for the following antimicrobial drugs and drug combinations: ampicillin, amoxicillin plus clavulanic acid, ampicillin plus sulbactam, cefotaxime, cefuroxime, chloramphenicol, ciprofloxacin, and doxycycline.
2 context sentences(design, population, supporting numbers)
Summary · context
Haemophilus test medium (HTM) was compared with Wilkins-Chalgren agar (WCA; supplemented with 15 micrograms/ml nicotinamide adenine dinucleotide (NAD)) for antibiotic susceptibility testing of 74 clinical isolates of Haemophilus influenzae and Haemophilus parainfluenzae.
Summary · context
The Bauer-Kirby agar disk diffusion method and the agar dilution procedure were the two tests employed.
In this study, NAD+ (nicotinamide adenine dinucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NAD+ (nicotinamide adenine dinucleotide).
Report a problemFND-0852943408
09LabNot a test of NAD+ (nicotinamide adenine dinucleotide) aloneIn vitro (cells)Activity measurement
In clinical Haemophilus isolates, NAD-supplemented Wilkins-Chalgren agar slightly antagonized rifampin compared with Haemophilus test medium.
In plain wordsIn lab tests, NAD-supplemented agar slightly reduced rifampin activity compared with Haemophilus test medium.
Peptide
NAD+ (nicotinamide adenine dinucleotide)
Outcome
DecreaseRifampin activity
Study
Haemophilus influenzae; Haemophilus parainfluenzaen = 74
Clinical Haemophilus isolates on supplemented Wilkins-Chalgren agar
Comparator
Haemophilus test medium
Outcome group
Infection and antimicrobial activity · Infection
Source sentences
Summary
However, WCA + NAD slightly antagonized rifampin.
2 context sentences(design, population, supporting numbers)
Summary · context
Haemophilus test medium (HTM) was compared with Wilkins-Chalgren agar (WCA; supplemented with 15 micrograms/ml nicotinamide adenine dinucleotide (NAD)) for antibiotic susceptibility testing of 74 clinical isolates of Haemophilus influenzae and Haemophilus parainfluenzae.
Summary · context
The Bauer-Kirby agar disk diffusion method and the agar dilution procedure were the two tests employed.
In this study, NAD+ (nicotinamide adenine dinucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NAD+ (nicotinamide adenine dinucleotide).
Report a problemFND-0852943409
10LabNot a test of NAD+ (nicotinamide adenine dinucleotide) aloneIn vitro (cells)Activity measurement
In clinical Haemophilus isolates, NAD-supplemented Wilkins-Chalgren agar significantly antagonized co-trimoxazole compared with Haemophilus test medium.
In plain wordsIn lab tests, NAD-supplemented agar reduced co-trimoxazole activity compared with Haemophilus test medium.
Peptide
NAD+ (nicotinamide adenine dinucleotide)
Outcome
DecreaseCo-trimoxazole activity
Study
Haemophilus influenzae; Haemophilus parainfluenzaen = 74
Clinical Haemophilus isolates on supplemented Wilkins-Chalgren agar
Comparator
Haemophilus test medium
Outcome group
Infection and antimicrobial activity · Infection
Source sentences
Summary
Co-trimoxazole was significantly antagonized by WCA + NAD.
2 context sentences(design, population, supporting numbers)
Summary · context
Haemophilus test medium (HTM) was compared with Wilkins-Chalgren agar (WCA; supplemented with 15 micrograms/ml nicotinamide adenine dinucleotide (NAD)) for antibiotic susceptibility testing of 74 clinical isolates of Haemophilus influenzae and Haemophilus parainfluenzae.
Summary · context
The Bauer-Kirby agar disk diffusion method and the agar dilution procedure were the two tests employed.
In this study, NAD+ (nicotinamide adenine dinucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NAD+ (nicotinamide adenine dinucleotide).
Report a problemFND-0852943410
11LabNot a test of NAD+ (nicotinamide adenine dinucleotide) aloneIn vitro (cells)Other
NAD-supplemented Wilkins-Chalgren agar was simpler to prepare than Haemophilus test medium and permitted NAD supplementation after plate storage.
In plain wordsIn lab tests, NAD-supplemented agar was simpler to prepare than Haemophilus test medium and allowed supplementation after storage.
Peptide
NAD+ (nicotinamide adenine dinucleotide)
Outcome
Not applicableMedium preparation
Study
Haemophilus influenzae; Haemophilus parainfluenzaen: not applicable
Clinical Haemophilus isolates on supplemented Wilkins-Chalgren agar
Comparator
Haemophilus test medium
Outcome group
Non-clinical applications · Infection
Source sentences
Summary
WCA + NAD was much simpler with regard to in-house preparation, and WCA plates could be supplemented with NAD following pouring, solidification and storage of the plates simply by surface spreading the required amount of NAD with a glass spatula
2 context sentences(design, population, supporting numbers)
Summary · context
Haemophilus test medium (HTM) was compared with Wilkins-Chalgren agar (WCA; supplemented with 15 micrograms/ml nicotinamide adenine dinucleotide (NAD)) for antibiotic susceptibility testing of 74 clinical isolates of Haemophilus influenzae and Haemophilus parainfluenzae.
Summary · context
The Bauer-Kirby agar disk diffusion method and the agar dilution procedure were the two tests employed.
In this study, NAD+ (nicotinamide adenine dinucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NAD+ (nicotinamide adenine dinucleotide).
Report a problemFND-0852943411

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Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

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