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Study · Measured the body's own peptide · 1993

5 results

Thymosin beta-4 expression is correlated with metastatic capacity of colorectal carcinomas.

Yamamoto T, Gotoh M, Kitajima M, Hirohashi S

Biochemical and biophysical research communications1 Jun 1993Cited by 39 (Europe PMC)

PMID8512568 (opens in a new tab)DOI10.1006/bbrc.1993.1682 (opens in a new tab)PepBankPUB-08512568
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Natural levels measured5

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyMechanism

    In surgical materials from colorectal carcinoma, thymosin beta‑4 expression was high in tumors without metastasis compared with non-tumorous mucosa.

    In plain wordsIn surgical samples, the body's own thymosin beta‑4 was higher in colorectal tumors without metastasis than in healthy mucosa.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseThymosin beta-4 expression in tumors without metastasis versus non-tumorous mucosa
    Study

    n: not reported in source

    Comparator
    Non-tumorous mucosa
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    Among surgical materials, thymosin beta-4 expression was high in tumors without metastasis in comparison with non-tumorous mucosa

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelCase report or seriesMechanism

    In one case with liver metastasis, thymosin beta‑4 expression was decreased in both the primary and the metastatic tumors.

    In plain wordsIn one patient with liver metastasis, the body's own thymosin beta‑4 level was lower in both the primary and the spread tumor.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseThymosin beta-4 expression in one case with liver metastasis
    Study

    n = 1

    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    but one case with liver metastasis showed decreased expression in both the primary and metastatic tumors.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  3. 03LabEndogenous levelIn vitro (cells)Mechanism

    In colorectal carcinoma cell lines, thymosin beta‑4 was strongly expressed in non-metastatic SW837 cells and weakly expressed in metastatic PMCO1 cells.

    In plain wordsIn colorectal cancer cells, the body's own thymosin beta‑4 was lower in a metastatic cell line than in a non-metastatic one.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseThymosin beta-4 cDNA expression in SW837 versus PMCO1
    Study

    n: not reported in source

    Colorectal carcinoma cell lines SW837 (non-metastatic) and PMCO1 (metastatic)
    Comparator
    Non-metastatic SW837 cells
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    We constructed a "non-metastatic cell (SW837)--metastatic cell (PMCO1)" subtraction library and identified one cDNA that was strongly expressed in SW837 but weakly expressed in PMCO1. The nucleotide sequence of the cDNA revealed that it encoded thymosin beta-4.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  4. 04LabEndogenous levelIn vitro (cells)Mechanism

    In four non-metastatic colorectal carcinoma cell lines, which produced no experimental liver metastasis in nude mice, thymosin beta‑4 expression was high.

    In plain wordsIn four non-metastatic colorectal cancer cell lines, the body's own thymosin beta‑4 level was high.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseThymosin beta-4 expression in non-metastatic cell lines
    Study

    n: not reported in source

    Four non-metastatic colorectal carcinoma cell lines
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    Four non-metastatic cell lines, which produced no experimental liver metastasis in nude mice, showed high expression of thymosin beta-4.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  5. 05LabEndogenous levelIn vitro (cells)Mechanism

    In three of four metastatic colorectal carcinoma cell lines, thymosin beta‑4 expression was weak.

    In plain wordsIn three of four metastatic colorectal cancer cell lines, the body's own thymosin beta‑4 level was low.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseThymosin beta-4 expression in metastatic cell lines
    Study

    n: not reported in source

    Four metastatic colorectal carcinoma cell lines
    Outcome group
    Tumor growth · Cancer

    Source sentences

    Summary
    However three of four metastatic cell lines showed weak expression of thymosin beta-4.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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