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Study · Not a test of the peptide alone · 1993

3 results

Identification of gonadorelin (LHRH) derivatives: comparison of reversed-phase high-performance liquid chromatography and micellar electrokinetic chromatography.

Corran PH, Sutcliffe N

Journal of chromatography1 Apr 1993Cited by 20 (Europe PMC)

PMID8491839 (opens in a new tab)DOI10.1016/0021-9673(93)80060-l (opens in a new tab)PepBankPUB-08491839
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Gonadorelin (GnRH, LHRH) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Gonadorelin (GnRH, LHRH).

  1. 01LabNot a test of Gonadorelin (GnRH, LHRH) aloneIn vitro (cell-free)Other

    In chromatography tests, RP-HPLC separated gonadorelin and five analogues with greater selectivity for structural differences than micellar systems, but one isocratic run was tedious.

    In plain wordsIn lab tests, a standard HPLC method told gonadorelin and five related drugs apart well, but a single run was slow.

    Peptide
    Gonadorelin (GnRH, LHRH)
    Outcome
    Not applicableRP-HPLC selectivity
    Study

    n: not reported in source

    chromatography
    Outcome group
    Analytical methods and detection · Pharmacology

    Source sentences

    Summary
    RP-HPLC exhibits greater selectivity towards structural differences, but complete separation of the peptides in one isocratic analytical run is tedious due to the large differences in retention.
    1 context sentence
    Summary · context
    A number of reversed-phase (RP) HPLC systems for the separation of gonadorelin (gonadoliberin, LHRH) and five therapeutically important analogues have been systematically examined.

    In this study, Gonadorelin (GnRH, LHRH) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Gonadorelin (GnRH, LHRH).

  2. 02LabNot a test of Gonadorelin (GnRH, LHRH) aloneIn vitro (cell-free)Other

    In chromatography tests, gradient RP-HPLC gave satisfactory separation of gonadorelin and its analogues in an acceptable time.

    In plain wordsIn lab tests, a gradient HPLC method separated gonadorelin and its related drugs in an acceptable time.

    Peptide
    Gonadorelin (GnRH, LHRH)
    Outcome
    Not applicableGradient elution separation
    Study

    n: not reported in source

    chromatography
    Outcome group
    Analytical methods and detection · Pharmacology

    Source sentences

    Summary
    Gradient elution gives satisfactory separation in an acceptable time span.
    1 context sentence
    Summary · context
    A number of reversed-phase (RP) HPLC systems for the separation of gonadorelin (gonadoliberin, LHRH) and five therapeutically important analogues have been systematically examined.

    In this study, Gonadorelin (GnRH, LHRH) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Gonadorelin (GnRH, LHRH).

  3. 03LabNot a test of Gonadorelin (GnRH, LHRH) aloneIn vitro (cell-free)Other

    In chromatography tests, only micellar electrokinetic chromatography with cetrimide micelles completely separated all six compounds, as rapidly as gradient RP-HPLC.

    In plain wordsIn lab tests, one capillary method with cetrimide separated all six compounds, as fast as the gradient HPLC method.

    Peptide
    Gonadorelin (GnRH, LHRH)
    Outcome
    Not applicableMEKC separation with cetrimide micelles
    Study

    n: not reported in source

    chromatography
    Outcome group
    Analytical methods and detection · Pharmacology

    Source sentences

    Summary
    Of the micellar systems examined (sodium dodecyl sulphate, cetrimide, 3-[(cholamidopropyl)dimethylamino]-1-propanesulphonate and Triton X-100) only MEKC with cetrimide micelles gave a complete separation showing selectivity similar, but not identical, to RP-HPLC, and providing a complete separation…
    1 context sentence
    Summary · context
    A number of reversed-phase (RP) HPLC systems for the separation of gonadorelin (gonadoliberin, LHRH) and five therapeutically important analogues have been systematically examined.

    In this study, Gonadorelin (GnRH, LHRH) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Gonadorelin (GnRH, LHRH).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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