Pre-operative gonadotrophin-releasing hormone agonist treatment in surgery for uterine leiomyomata.

Golan A, Bukovsky I, Pansky M, Schneider D, Weinraub Z, Caspi E

Human reproduction (Oxford, England)1 Mar 1993Cited by 35 (Europe PMC)

PMID8473466DOI10.1093/oxfordjournals.humrep.a138070PepBankPUB-08473466

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

01HumanRandomized controlled trialEfficacy outcome
In women with symptomatic fibroids, pre-operative D-Trp6 LHRH shortened hysterectomy duration compared with no pre-operative treatment.
In plain wordsIn women with fibroids, pre-operative D-Trp6 LHRH shortened hysterectomy duration compared with no pre-operative treatment.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseHysterectomy duration
Study
n: not reported in source
Comparator
No pre-operative treatment
Outcome group
Surgical outcomes · Reproductive and sexual health
Studied dose
Dose not stated · intramuscularAs given in this study (human).
Measurements
Surgery duration
49 min
treated hysterectomy group
Surgery duration
70 min
control hysterectomy group
Source sentences
Summary
The duration of surgery was shorter in the study group (49 versus 70 min in the hysterectomy group) and intra-operative blood loss was less (208 versus 309 ml in the hysterectomies and 320 versus 476 ml in the myomectomies).
3 context sentences(design, population, supporting numbers)
Summary · context
To determine whether pre-operative treatment with gonadotrophin-releasing hormone (GnRH) analogue may have a beneficial effect on surgery outcome, 53 patients with symptomatic fibroid uteri awaiting myomectomy or transabdominal hysterectomy (TAH), were randomly divided into a study group (n = 29) an…
Summary · context
The study group of patients were treated by an i.m. injection of D-Trp6 LHRH microcapsules at 2 months and 1 month prior to surgery.
Summary · context
The control group had no pre-operative treatment.
Report a problemFND-0847346601
02HumanRandomized controlled trialEfficacy outcome
In women with symptomatic fibroids, pre-operative D-Trp6 LHRH reduced hysterectomy blood loss compared with no pre-operative treatment.
In plain wordsIn women with fibroids, pre-operative D-Trp6 LHRH reduced hysterectomy blood loss compared with no pre-operative treatment.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseHysterectomy blood loss
Study
n: not reported in source
Comparator
No pre-operative treatment
Outcome group
Surgical outcomes · Reproductive and sexual health
Studied dose
Dose not stated · intramuscularAs given in this study (human).
Measurements
Blood loss
208 ml
treated hysterectomy group
Blood loss
309 ml
control hysterectomy group
Source sentences
Summary
The duration of surgery was shorter in the study group (49 versus 70 min in the hysterectomy group) and intra-operative blood loss was less (208 versus 309 ml in the hysterectomies and 320 versus 476 ml in the myomectomies).
3 context sentences(design, population, supporting numbers)
Summary · context
To determine whether pre-operative treatment with gonadotrophin-releasing hormone (GnRH) analogue may have a beneficial effect on surgery outcome, 53 patients with symptomatic fibroid uteri awaiting myomectomy or transabdominal hysterectomy (TAH), were randomly divided into a study group (n = 29) an…
Summary · context
The study group of patients were treated by an i.m. injection of D-Trp6 LHRH microcapsules at 2 months and 1 month prior to surgery.
Summary · context
The control group had no pre-operative treatment.
Report a problemFND-0847346602
03HumanRandomized controlled trialEfficacy outcome
In women with symptomatic fibroids, pre-operative D-Trp6 LHRH reduced myomectomy blood loss compared with no pre-operative treatment.
In plain wordsIn women with fibroids, pre-operative D-Trp6 LHRH reduced myomectomy blood loss compared with no pre-operative treatment.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseMyomectomy blood loss
Study
n: not reported in source
Comparator
No pre-operative treatment
Outcome group
Surgical outcomes · Reproductive and sexual health
Studied dose
Dose not stated · intramuscularAs given in this study (human).
Measurements
Blood loss
320 ml
treated myomectomy group
Blood loss
476 ml
control myomectomy group
Source sentences
Summary
The duration of surgery was shorter in the study group (49 versus 70 min in the hysterectomy group) and intra-operative blood loss was less (208 versus 309 ml in the hysterectomies and 320 versus 476 ml in the myomectomies).
3 context sentences(design, population, supporting numbers)
Summary · context
To determine whether pre-operative treatment with gonadotrophin-releasing hormone (GnRH) analogue may have a beneficial effect on surgery outcome, 53 patients with symptomatic fibroid uteri awaiting myomectomy or transabdominal hysterectomy (TAH), were randomly divided into a study group (n = 29) an…
Summary · context
The study group of patients were treated by an i.m. injection of D-Trp6 LHRH microcapsules at 2 months and 1 month prior to surgery.
Summary · context
The control group had no pre-operative treatment.
Report a problemFND-0847346603

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

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MeSH terms

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