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Study · Randomized controlled trial · n = 20 · 1993

3 results

Placebo-controlled, double-blind, cross-over trial of glutathione therapy in male infertility.

Lenzi A, Culasso F, Gandini L, Lombardo F, Dondero F

Human reproduction (Oxford, England)1 Oct 1993Cited by 121 (Europe PMC)

PMID8300824 (opens in a new tab)DOI10.1093/oxfordjournals.humrep.a137909 (opens in a new tab)PepBankPUB-08300824
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In infertile patients with varicocele or genital tract inflammation, glutathione significantly improved the percentage of forward sperm motility versus placebo.

    In plain wordsIn infertile patients, glutathione improved the percentage of sperm moving forward compared with placebo.

    Peptide
    Glutathione
    Outcome
    IncreasePercentage of forward motility
    Study

    n = 20

    Comparator
    Placebo
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    600 mg every other day · intramuscular · 2 monthsAs given in this study (human).

    Source sentences

    Summary
    Glutathione therapy demonstrated a statistically significant positive effect on sperm motility, in particular on the percentage of forward motility, the kinetic parameters of the computerized analysis and on sperm morphology.
    2 context sentences
    Summary · context
    Glutathione therapy was used for 2 months in a placebo-controlled double-blind cross-over trial of 20 infertile patients with dyspermia associated with unilateral varicocele (VAR) or germ-free genital tract inflammation (INF).
    Summary · context
    The patients were randomly and blindly assigned to treatment (one i.m. injection every other day of either 600 mg glutathione or an equal volume of a placebo preparation).
  2. 02HumanRandomized controlled trialEfficacy outcome

    In infertile patients with varicocele or genital tract inflammation, glutathione significantly improved computerized sperm kinetic parameters versus placebo.

    In plain wordsIn infertile patients, glutathione improved computer-measured sperm movement parameters compared with placebo.

    Peptide
    Glutathione
    Outcome
    IncreaseComputerized sperm kinetic parameters
    Study

    n = 20

    Comparator
    Placebo
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    600 mg every other day · intramuscular · 2 monthsAs given in this study (human).

    Source sentences

    Summary
    Glutathione therapy demonstrated a statistically significant positive effect on sperm motility, in particular on the percentage of forward motility, the kinetic parameters of the computerized analysis and on sperm morphology.
    2 context sentences
    Summary · context
    Glutathione therapy was used for 2 months in a placebo-controlled double-blind cross-over trial of 20 infertile patients with dyspermia associated with unilateral varicocele (VAR) or germ-free genital tract inflammation (INF).
    Summary · context
    The patients were randomly and blindly assigned to treatment (one i.m. injection every other day of either 600 mg glutathione or an equal volume of a placebo preparation).
  3. 03HumanRandomized controlled trialEfficacy outcome

    In infertile patients with varicocele or genital tract inflammation, glutathione significantly improved sperm morphology versus placebo.

    In plain wordsIn infertile patients, glutathione improved sperm shape compared with placebo.

    Peptide
    Glutathione
    Outcome
    IncreaseSperm morphology
    Study

    n = 20

    Comparator
    Placebo
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    600 mg every other day · intramuscular · 2 monthsAs given in this study (human).

    Source sentences

    Summary
    Glutathione therapy demonstrated a statistically significant positive effect on sperm motility, in particular on the percentage of forward motility, the kinetic parameters of the computerized analysis and on sperm morphology.
    2 context sentences
    Summary · context
    Glutathione therapy was used for 2 months in a placebo-controlled double-blind cross-over trial of 20 infertile patients with dyspermia associated with unilateral varicocele (VAR) or germ-free genital tract inflammation (INF).
    Summary · context
    The patients were randomly and blindly assigned to treatment (one i.m. injection every other day of either 600 mg glutathione or an equal volume of a placebo preparation).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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