Physiological estrogen replacement may enhance the effectiveness of the gonadotropin-releasing hormone agonist in the treatment of hirsutism.

Carmina E, Janni A, Lobo RA

The Journal of clinical endocrinology and metabolism1 Jan 1994Cited by 23 (Europe PMC)

PMID8288696DOI10.1210/jcem.78.1.8288696PepBankPUB-08288696

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study17

7 results from studies that gave the peptide. 7 results from people.

01HumanRandomized controlled trialSafety outcome
In women with hirsutism, amenorrhea occurred only in the Decapeptyl-alone group and not in the group that also received hormone replacement.
In plain wordsIn women with hirsutism, amenorrhea occurred only in the Decapeptyl-alone group, not in the group that also had hormone replacement.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseAmenorrhea
Study
n = 22
Comparator
Decapeptyl with hormone replacement
Outcome group
Adverse events · Endocrine and hormones
Studied dose
3.75 mg every 28 days · intramuscular · 6 monthsAs given in this study (human).
Source sentences
Summary
Amenorrhea and vasomotor symptoms were observed only with GnRH-A alone.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we evaluated the effects of low dose (physiological) estrogen replacement on the side-effects and clinical and hormonal parameters of 22 hirsute women with ovarian hyperandrogenism when treated with a long-acting GnRH-A, Decapeptyl.
Report a problemFND-0828869612
02HumanRandomized controlled trialSafety outcome
In women with hirsutism, vasomotor symptoms occurred only in the Decapeptyl-alone group and not in the group that also received hormone replacement.
In plain wordsIn women with hirsutism, vasomotor symptoms occurred only in the Decapeptyl-alone group, not in the group that also had hormone replacement.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseVasomotor symptoms
Study
n = 22
Comparator
Decapeptyl with hormone replacement
Outcome group
Adverse events · Endocrine and hormones
Studied dose
3.75 mg every 28 days · intramuscular · 6 monthsAs given in this study (human).
Source sentences
Summary
Amenorrhea and vasomotor symptoms were observed only with GnRH-A alone.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we evaluated the effects of low dose (physiological) estrogen replacement on the side-effects and clinical and hormonal parameters of 22 hirsute women with ovarian hyperandrogenism when treated with a long-acting GnRH-A, Decapeptyl.
Report a problemFND-0828869613
03HumanRandomized controlled trialEfficacy outcome
In women with hirsutism, Decapeptyl alone suppressed LH after six months.
In plain wordsIn women with hirsutism, Decapeptyl alone suppressed LH after six months.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseLH suppression
Study
n = 10
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
3.75 mg every 28 days · intramuscular · 6 monthsAs given in this study (human).
Source sentences
Summary
After 6 months, LH was suppressed in both groups, whereas FSH was significantly reduced only in the group receiving GnRH-A with estrogen (2.5 +/- 4 vs. 4.8 +/- 0.6 IU/L; P < 0.01).
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we evaluated the effects of low dose (physiological) estrogen replacement on the side-effects and clinical and hormonal parameters of 22 hirsute women with ovarian hyperandrogenism when treated with a long-acting GnRH-A, Decapeptyl.
Report a problemFND-0828869601
04HumanRandomized controlled trialEfficacy outcome
In women with hirsutism, Decapeptyl alone did not significantly reduce FSH.
In plain wordsIn women with hirsutism, Decapeptyl alone did not significantly reduce FSH.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeFSH
Study
n = 10
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
3.75 mg every 28 days · intramuscular · 6 monthsAs given in this study (human).
Measurements
FSH, reported pair
2.5 IU/L
first reported value; group or time order not explicit
FSH, reported pair
4.8 IU/L
second reported value; group or time order not explicit
Source sentences
Summary
After 6 months, LH was suppressed in both groups, whereas FSH was significantly reduced only in the group receiving GnRH-A with estrogen (2.5 +/- 4 vs. 4.8 +/- 0.6 IU/L; P < 0.01).
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we evaluated the effects of low dose (physiological) estrogen replacement on the side-effects and clinical and hormonal parameters of 22 hirsute women with ovarian hyperandrogenism when treated with a long-acting GnRH-A, Decapeptyl.
Report a problemFND-0828869603
05HumanRandomized controlled trialEfficacy outcome
In women with hirsutism, Decapeptyl alone reduced serum androgen levels.
In plain wordsIn women with hirsutism, Decapeptyl alone reduced serum androgen levels.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseSerum androgens
Study
n = 10
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
3.75 mg every 28 days · intramuscular · 6 monthsAs given in this study (human).
Source sentences
Summary
Serum androgen levels were reduced in both groups,
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we evaluated the effects of low dose (physiological) estrogen replacement on the side-effects and clinical and hormonal parameters of 22 hirsute women with ovarian hyperandrogenism when treated with a long-acting GnRH-A, Decapeptyl.
Report a problemFND-0828869605
06HumanRandomized controlled trialEfficacy outcome
In women with hirsutism, Decapeptyl alone reduced polycystic ovarian appearance on ultrasound.
In plain wordsIn women with hirsutism, Decapeptyl alone reduced polycystic ovarian appearance on ultrasound.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreasePolycystic ovarian appearance
Study
n = 10
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
3.75 mg every 28 days · intramuscular · 6 monthsAs given in this study (human).
Source sentences
Summary
The reduction in hirsutism scores was greater with hormonal replacement (FG scores, -4.1 +/- 0.3 vs. -2.5 +/- 0.3; P < 0.05), whereas the polycystic appearance of ovaries by ultrasound was decreased in both groups.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we evaluated the effects of low dose (physiological) estrogen replacement on the side-effects and clinical and hormonal parameters of 22 hirsute women with ovarian hyperandrogenism when treated with a long-acting GnRH-A, Decapeptyl.
Report a problemFND-0828869610
07HumanRandomized controlled trialSafety outcome
In women with hirsutism, Decapeptyl alone significantly increased serum osteocalcin.
In plain wordsIn women with hirsutism, Decapeptyl alone increased a marker of bone turnover.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseSerum osteocalcin
Study
n = 10
Outcome group
Bone and joint · Musculoskeletal
Studied dose
3.75 mg every 28 days · intramuscular · 6 monthsAs given in this study (human).
Measurements
Serum osteocalcin
0.49 nmol/L
Decapeptyl alone group, before treatment
Serum osteocalcin
0.64 nmol/L
Decapeptyl alone group, after treatment
Source sentences
Summary
Serum osteocalcin rose significantly with GnRH-A alone, reflecting a change in bone turnover (0.49 +/- 0.05 to 0.64 +/- 0.09 nmol/L; P < 0.05), but was unchanged with hormonal replacement.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we evaluated the effects of low dose (physiological) estrogen replacement on the side-effects and clinical and hormonal parameters of 22 hirsute women with ovarian hyperandrogenism when treated with a long-acting GnRH-A, Decapeptyl.
Report a problemFND-0828869614

Studies that did not test the peptide alone10

In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Triptorelin (Trelstar, Decapeptyl).

08HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneRandomized controlled trialEfficacy outcome
In women with hirsutism, Decapeptyl and hormone replacement reduced testosterone more than Decapeptyl alone.
In plain wordsIn women with hirsutism, Decapeptyl and hormone replacement reduced testosterone more than Decapeptyl alone.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseTestosterone reduction
Study
n = 22
Comparator
Decapeptyl alone
Outcome group
Sex hormones and fertility · Endocrine and hormones
Measurements
Testosterone
1.73 nmol/L
Decapeptyl with hormone replacement group
Testosterone
2.57 nmol/L
Decapeptyl alone group
Source sentences
Summary
Serum androgen levels were reduced in both groups, although the reduction of testosterone and unbound testosterone was greater in the group receiving hormonal replacement [1.73 +/- 0.3 vs. 2.57 +/- 0.4 nmol/L for testosterone (P < 0.05); 8.3 +/- 1 vs. 14.6 +/- 2.8 pmol/L for unbound testosterone (P < 0.05)].
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we evaluated the effects of low dose (physiological) estrogen replacement on the side-effects and clinical and hormonal parameters of 22 hirsute women with ovarian hyperandrogenism when treated with a long-acting GnRH-A, Decapeptyl.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-0828869607
09HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneRandomized controlled trialEfficacy outcome
In women with hirsutism, Decapeptyl and hormone replacement reduced unbound testosterone more than Decapeptyl alone.
In plain wordsIn women with hirsutism, Decapeptyl and hormone replacement reduced unbound testosterone more than Decapeptyl alone.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseUnbound testosterone reduction
Study
n = 22
Comparator
Decapeptyl alone
Outcome group
Sex hormones and fertility · Endocrine and hormones
Measurements
Unbound testosterone
8.3 pmol/L
Decapeptyl with hormone replacement group
Unbound testosterone
14.6 pmol/L
Decapeptyl alone group
Source sentences
Summary
Serum androgen levels were reduced in both groups, although the reduction of testosterone and unbound testosterone was greater in the group receiving hormonal replacement [1.73 +/- 0.3 vs. 2.57 +/- 0.4 nmol/L for testosterone (P < 0.05); 8.3 +/- 1 vs. 14.6 +/- 2.8 pmol/L for unbound testosterone (P < 0.05)].
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we evaluated the effects of low dose (physiological) estrogen replacement on the side-effects and clinical and hormonal parameters of 22 hirsute women with ovarian hyperandrogenism when treated with a long-acting GnRH-A, Decapeptyl.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-0828869608
10HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneRandomized controlled trialEfficacy outcome
In women with hirsutism, Decapeptyl and hormone replacement reduced hirsutism scores more than Decapeptyl alone.
In plain wordsIn women with hirsutism, Decapeptyl and hormone replacement reduced hirsutism scores more than Decapeptyl alone.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseHirsutism score reduction
Study
n = 22
Comparator
Decapeptyl alone
Outcome group
Skin and hair · Skin and wound
Measurements
FG score change
−4.1 points
hormone replacement regimen
FG score change
−2.5 points
Decapeptyl alone
Source sentences
Summary
The reduction in hirsutism scores was greater with hormonal replacement (FG scores, -4.1 +/- 0.3 vs. -2.5 +/- 0.3; P < 0.05), whereas the polycystic appearance of ovaries by ultrasound was decreased in both groups.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we evaluated the effects of low dose (physiological) estrogen replacement on the side-effects and clinical and hormonal parameters of 22 hirsute women with ovarian hyperandrogenism when treated with a long-acting GnRH-A, Decapeptyl.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-0828869609
11HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneRandomized controlled trialEfficacy outcome
In women with hirsutism, Decapeptyl with estrogen and medroxyprogesterone suppressed LH after six months.
In plain wordsIn women with hirsutism, the Decapeptyl and hormone replacement regimen suppressed LH after six months.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseLH suppression
Study
n = 12
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
After 6 months, LH was suppressed in both groups, whereas FSH was significantly reduced only in the group receiving GnRH-A with estrogen (2.5 +/- 4 vs. 4.8 +/- 0.6 IU/L; P < 0.01).
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we evaluated the effects of low dose (physiological) estrogen replacement on the side-effects and clinical and hormonal parameters of 22 hirsute women with ovarian hyperandrogenism when treated with a long-acting GnRH-A, Decapeptyl.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-0828869602
12HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneRandomized controlled trialEfficacy outcome
In women with hirsutism, FSH decreased significantly only with Decapeptyl and hormone replacement.
In plain wordsIn women with hirsutism, FSH decreased significantly only with Decapeptyl and hormone replacement.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseFSH
Study
n = 12
Outcome group
Sex hormones and fertility · Endocrine and hormones
Measurements
FSH, reported pair
2.5 IU/L
first reported value; group or time order not explicit
FSH, reported pair
4.8 IU/L
second reported value; group or time order not explicit
Source sentences
Summary
After 6 months, LH was suppressed in both groups, whereas FSH was significantly reduced only in the group receiving GnRH-A with estrogen (2.5 +/- 4 vs. 4.8 +/- 0.6 IU/L; P < 0.01).
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we evaluated the effects of low dose (physiological) estrogen replacement on the side-effects and clinical and hormonal parameters of 22 hirsute women with ovarian hyperandrogenism when treated with a long-acting GnRH-A, Decapeptyl.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-0828869604
13HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneRandomized controlled trialEfficacy outcome
In women with hirsutism, Decapeptyl and hormone replacement reduced serum androgen levels.
In plain wordsIn women with hirsutism, Decapeptyl and hormone replacement reduced serum androgen levels.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseSerum androgens
Study
n = 12
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
Serum androgen levels were reduced in both groups,
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we evaluated the effects of low dose (physiological) estrogen replacement on the side-effects and clinical and hormonal parameters of 22 hirsute women with ovarian hyperandrogenism when treated with a long-acting GnRH-A, Decapeptyl.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-0828869606
14HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneRandomized controlled trialEfficacy outcome
In women with hirsutism, Decapeptyl and hormone replacement reduced polycystic ovarian appearance on ultrasound.
In plain wordsIn women with hirsutism, Decapeptyl and hormone replacement reduced polycystic ovarian appearance on ultrasound.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreasePolycystic ovarian appearance
Study
n = 12
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
The reduction in hirsutism scores was greater with hormonal replacement (FG scores, -4.1 +/- 0.3 vs. -2.5 +/- 0.3; P < 0.05), whereas the polycystic appearance of ovaries by ultrasound was decreased in both groups.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we evaluated the effects of low dose (physiological) estrogen replacement on the side-effects and clinical and hormonal parameters of 22 hirsute women with ovarian hyperandrogenism when treated with a long-acting GnRH-A, Decapeptyl.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-0828869611
15HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneRandomized controlled trialSafety outcome
In women with hirsutism, serum osteocalcin remained unchanged with Decapeptyl and hormone replacement.
In plain wordsIn women with hirsutism, a bone turnover marker remained unchanged with Decapeptyl and hormone replacement.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeSerum osteocalcin
Study
n = 12
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
Serum osteocalcin rose significantly with GnRH-A alone, reflecting a change in bone turnover (0.49 +/- 0.05 to 0.64 +/- 0.09 nmol/L; P < 0.05), but was unchanged with hormonal replacement.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we evaluated the effects of low dose (physiological) estrogen replacement on the side-effects and clinical and hormonal parameters of 22 hirsute women with ovarian hyperandrogenism when treated with a long-acting GnRH-A, Decapeptyl.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-0828869615
16HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneNon-randomized trialEfficacy outcome
In women with hirsutism, Decapeptyl and hormone replacement further reduced hirsutism scores into the normal range after one year.
In plain wordsIn women with hirsutism, Decapeptyl and hormone replacement further reduced hirsutism scores into the normal range after one year.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseHirsutism at one year
Study
n: not reported in source
Outcome group
Skin and hair · Skin and wound
Measurements
FG score
4.9 points
Decapeptyl with hormone replacement, after 1 year
Source sentences
Summary
A further improvement of hirsutism, with scores dropping into the normal range (4.9 +/- 0.7), as well as a normalization of ovarian morphology were evident at this time.
2 context sentences(design, population, supporting numbers)
Summary · context
Patients receiving hormonal replacement had treatment extended to 1 yr.
Summary · context
In this study, we evaluated the effects of low dose (physiological) estrogen replacement on the side-effects and clinical and hormonal parameters of 22 hirsute women with ovarian hyperandrogenism when treated with a long-acting GnRH-A, Decapeptyl.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-0828869616
17HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneNon-randomized trialEfficacy outcome
In women with hirsutism, ovarian morphology normalized after one year of Decapeptyl and hormone replacement.
In plain wordsIn women with hirsutism, ovarian morphology normalized after one year of Decapeptyl and hormone replacement.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
Not applicableOvarian morphology at one year
Study
n: not reported in source
Outcome group
Sex hormones and fertility · Endocrine and hormones
Source sentences
Summary
A further improvement of hirsutism, with scores dropping into the normal range (4.9 +/- 0.7), as well as a normalization of ovarian morphology were evident at this time.
2 context sentences(design, population, supporting numbers)
Summary · context
Patients receiving hormonal replacement had treatment extended to 1 yr.
Summary · context
In this study, we evaluated the effects of low dose (physiological) estrogen replacement on the side-effects and clinical and hormonal parameters of 22 hirsute women with ovarian hyperandrogenism when treated with a long-acting GnRH-A, Decapeptyl.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Report a problemFND-0828869617

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

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