Administration of LHRH analog can improve working memory in aged female rats.

Alliot J, Nauton P, Bruhat MA

Psychoneuroendocrinology1 Jan 1993Cited by 9 (Europe PMC)

PMID8127945DOI10.1016/0306-4530(93)90031-fPepBankPUB-08127945

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In aged female rats, D-Trp6-LHRH counteracted age-related impairment in task performance.
In plain wordsIn rats, D-Trp6-LHRH counteracted age-related impairment in memory task performance.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseWorking memory performance
Study
ratn: not reported in source
22-month-old female rats in a matching-to-sample task
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
800 micrograms/kg microcapsules releasing 5 micrograms per day · subcutaneousAs given in this study (rat).
Source sentences
Summary
Administration of D-Trp6-LHRH counteracted the deleterious effect of age on performance and inhibited ovary function.
2 context sentences(design, population, supporting numbers)
Summary · context
This experiment investigates the effect of administering an analog of luteinizing hormone-releasing hormone (LHRH), D-Trp6-LHRH, to 22-mo-old female rats submitted to successive trainings in a water-reinforced matching to sample task since the age of three months.
Summary · context
Animals were injected SC with a long-lasting microcapsule formulation (800 micrograms/kg continuously releasing 5 micrograms D-Trp6-LHRH per day for at least 28 days).
Report a problemFND-0812794501
02AnimalAnimal study (in vivo)Efficacy outcome
In aged female rats, D-Trp6-LHRH inhibited ovarian function.
In plain wordsIn rats, D-Trp6-LHRH inhibited ovarian function.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseOvarian function
Study
ratn: not reported in source
22-month-old female rats in a matching-to-sample task
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
800 micrograms/kg microcapsules releasing 5 micrograms per day · subcutaneousAs given in this study (rat).
Source sentences
Summary
Administration of D-Trp6-LHRH counteracted the deleterious effect of age on performance and inhibited ovary function.
2 context sentences(design, population, supporting numbers)
Summary · context
This experiment investigates the effect of administering an analog of luteinizing hormone-releasing hormone (LHRH), D-Trp6-LHRH, to 22-mo-old female rats submitted to successive trainings in a water-reinforced matching to sample task since the age of three months.
Summary · context
Animals were injected SC with a long-lasting microcapsule formulation (800 micrograms/kg continuously releasing 5 micrograms D-Trp6-LHRH per day for at least 28 days).
Report a problemFND-0812794502
03AnimalAnimal study (in vivo)Other
In aged female rats, D-Trp6-LHRH did not modify plasma estradiol levels.
In plain wordsIn rats, D-Trp6-LHRH did not change plasma estradiol levels.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changePlasma estradiol
Study
ratn: not reported in source
22-month-old female rats in a matching-to-sample task
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
800 micrograms/kg microcapsules releasing 5 micrograms per day · subcutaneousAs given in this study (rat).
Source sentences
Summary
However, hormone plasma levels were not modified.
3 context sentences(design, population, supporting numbers)
Summary · context
The action of the analog on ovary weight and estradiol and progesterone levels was also studied.
Summary · context
This experiment investigates the effect of administering an analog of luteinizing hormone-releasing hormone (LHRH), D-Trp6-LHRH, to 22-mo-old female rats submitted to successive trainings in a water-reinforced matching to sample task since the age of three months.
Summary · context
Animals were injected SC with a long-lasting microcapsule formulation (800 micrograms/kg continuously releasing 5 micrograms D-Trp6-LHRH per day for at least 28 days).
Report a problemFND-0812794503
04AnimalAnimal study (in vivo)Other
In aged female rats, D-Trp6-LHRH did not modify plasma progesterone levels.
In plain wordsIn rats, D-Trp6-LHRH did not change plasma progesterone levels.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changePlasma progesterone
Study
ratn: not reported in source
22-month-old female rats in a matching-to-sample task
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
800 micrograms/kg microcapsules releasing 5 micrograms per day · subcutaneousAs given in this study (rat).
Source sentences
Summary
However, hormone plasma levels were not modified.
3 context sentences(design, population, supporting numbers)
Summary · context
The action of the analog on ovary weight and estradiol and progesterone levels was also studied.
Summary · context
This experiment investigates the effect of administering an analog of luteinizing hormone-releasing hormone (LHRH), D-Trp6-LHRH, to 22-mo-old female rats submitted to successive trainings in a water-reinforced matching to sample task since the age of three months.
Summary · context
Animals were injected SC with a long-lasting microcapsule formulation (800 micrograms/kg continuously releasing 5 micrograms D-Trp6-LHRH per day for at least 28 days).
Report a problemFND-0812794504

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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