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Study · Animal study (in vivo) · mouse and chicken · 1993

11 results

[The protective effect of peptides from the thymus and tracheal mucosa in an experimental respiratory influenzal infection].

Khavinson VKh, Kozhemiakin AL, Volgarev AP, Platonov VG

Zhurnal mikrobiologii, epidemiologii i immunobiologii1 Jan 1993

PMID8067076 (opens in a new tab)PepBankPUB-08067076
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with type A influenza, thymalin was less effective at preventing death than remantadin.

    In plain wordsIn mice with type A influenza, thymalin prevented death less effectively than remantadin.

    Peptide
    Thymalin
    Outcome
    IncreaseDeath rate with type A influenza versus remantadin
    Study

    mousen: not reported in source

    Experimental influenza infection
    Comparator
    remantadin
    Outcome group
    Mortality · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In case of type A virus the effectiveness of the preparations was distributed as follows: remantadin > thymogen > thymalin > > PTM.
    2 context sentences
    Summary · context
    To evaluate the possible antiviral activity of a number of peptide bioregulators, an acute influenza infection was induced in developing chick embryos and mice.
    Summary · context
    In experiments on mice, the preparations were introduced 24 hours and 1 hour before and 24, 48 and 72 hours after intranasal challenge.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with type A influenza, thymalin was less effective at preventing death than thymogen.

    In plain wordsIn mice with type A influenza, thymalin prevented death less effectively than thymogen.

    Peptide
    Thymalin
    Outcome
    IncreaseDeath rate with type A influenza versus thymogen
    Study

    mousen: not reported in source

    Experimental influenza infection
    Comparator
    thymogen
    Outcome group
    Mortality · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In case of type A virus the effectiveness of the preparations was distributed as follows: remantadin > thymogen > thymalin > > PTM.
    2 context sentences
    Summary · context
    To evaluate the possible antiviral activity of a number of peptide bioregulators, an acute influenza infection was induced in developing chick embryos and mice.
    Summary · context
    In experiments on mice, the preparations were introduced 24 hours and 1 hour before and 24, 48 and 72 hours after intranasal challenge.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice with type A influenza, thymalin was more effective at preventing death than PTM.

    In plain wordsIn mice with type A influenza, thymalin prevented death more effectively than PTM.

    Peptide
    Thymalin
    Outcome
    DecreaseDeath rate with type A influenza versus PTM
    Study

    mousen: not reported in source

    Experimental influenza infection
    Comparator
    PTM
    Outcome group
    Mortality · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In case of type A virus the effectiveness of the preparations was distributed as follows: remantadin > thymogen > thymalin > > PTM.
    2 context sentences
    Summary · context
    To evaluate the possible antiviral activity of a number of peptide bioregulators, an acute influenza infection was induced in developing chick embryos and mice.
    Summary · context
    In experiments on mice, the preparations were introduced 24 hours and 1 hour before and 24, 48 and 72 hours after intranasal challenge.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice with type A influenza, thymogen ranked below remantadin for mortality-based protection.

    In plain wordsIn mice with type A influenza, thymogen provided less mortality protection than remantadin.

    Peptide
    Thymogen (oglufanide)
    Outcome
    DecreaseType A influenza mortality protection versus remantadin
    Study

    mousen: not reported in source

    Experimental influenza infection
    Comparator
    remantadin
    Outcome group
    Mortality · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In case of type A virus the effectiveness of the preparations was distributed as follows: remantadin > thymogen > thymalin > > PTM.
    4 context sentences
    Summary · context
    The effectiveness of the preparations was evaluated by the death rate of the animals.
    Summary · context
    To evaluate the possible antiviral activity of a number of peptide bioregulators, an acute influenza infection was induced in developing chick embryos and mice.
    Summary · context
    Four peptide preparations were used: two medicinal peptide preparations of the thymus (thymalin and thymogen) and peptide preparations obtained from the tracheal mucosa (PTM) and lung parenchyma (PLP) of calves according to the technology used for obtaining thymalin.
    Summary · context
    In experiments on mice, the preparations were introduced 24 hours and 1 hour before and 24, 48 and 72 hours after intranasal challenge.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In mice with type A influenza, thymogen ranked above thymalin for mortality-based protection.

    In plain wordsIn mice with type A influenza, thymogen provided more mortality protection than thymalin.

    Peptide
    Thymogen (oglufanide)
    Outcome
    IncreaseType A influenza mortality protection versus thymalin
    Study

    mousen: not reported in source

    Experimental influenza infection
    Comparator
    thymalin
    Outcome group
    Mortality · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In case of type A virus the effectiveness of the preparations was distributed as follows: remantadin > thymogen > thymalin > > PTM.
    4 context sentences
    Summary · context
    The effectiveness of the preparations was evaluated by the death rate of the animals.
    Summary · context
    To evaluate the possible antiviral activity of a number of peptide bioregulators, an acute influenza infection was induced in developing chick embryos and mice.
    Summary · context
    Four peptide preparations were used: two medicinal peptide preparations of the thymus (thymalin and thymogen) and peptide preparations obtained from the tracheal mucosa (PTM) and lung parenchyma (PLP) of calves according to the technology used for obtaining thymalin.
    Summary · context
    In experiments on mice, the preparations were introduced 24 hours and 1 hour before and 24, 48 and 72 hours after intranasal challenge.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In mice with type A influenza, thymogen ranked above PTM for mortality-based protection.

    In plain wordsIn mice with type A influenza, thymogen provided more mortality protection than PTM.

    Peptide
    Thymogen (oglufanide)
    Outcome
    IncreaseType A influenza mortality protection versus PTM
    Study

    mousen: not reported in source

    Experimental influenza infection
    Comparator
    PTM
    Outcome group
    Mortality · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In case of type A virus the effectiveness of the preparations was distributed as follows: remantadin > thymogen > thymalin > > PTM.
    4 context sentences
    Summary · context
    The effectiveness of the preparations was evaluated by the death rate of the animals.
    Summary · context
    To evaluate the possible antiviral activity of a number of peptide bioregulators, an acute influenza infection was induced in developing chick embryos and mice.
    Summary · context
    Four peptide preparations were used: two medicinal peptide preparations of the thymus (thymalin and thymogen) and peptide preparations obtained from the tracheal mucosa (PTM) and lung parenchyma (PLP) of calves according to the technology used for obtaining thymalin.
    Summary · context
    In experiments on mice, the preparations were introduced 24 hours and 1 hour before and 24, 48 and 72 hours after intranasal challenge.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In mice with type B influenza, thymogen had no influence on death rate.

    In plain wordsIn mice with type B influenza, thymogen did not change death rate.

    Peptide
    Thymogen (oglufanide)
    Outcome
    No significant changeType B influenza death rate
    Study

    mousen: not reported in source

    Experimental influenza infection
    Outcome group
    Mortality · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In case of type B virus, adapromin and PTM were found to produce a similar effect, while the preparations of the thymus and PLP had no influence on the death rate of the animals.
    3 context sentences
    Summary · context
    To evaluate the possible antiviral activity of a number of peptide bioregulators, an acute influenza infection was induced in developing chick embryos and mice.
    Summary · context
    Four peptide preparations were used: two medicinal peptide preparations of the thymus (thymalin and thymogen) and peptide preparations obtained from the tracheal mucosa (PTM) and lung parenchyma (PLP) of calves according to the technology used for obtaining thymalin.
    Summary · context
    In experiments on mice, the preparations were introduced 24 hours and 1 hour before and 24, 48 and 72 hours after intranasal challenge.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In developing chick embryos, thymogen did not affect type A influenza infection.

    In plain wordsIn chick embryos, thymogen did not affect type A influenza infection.

    Peptide
    Thymogen (oglufanide)
    Outcome
    No significant changeType A influenza infection in embryos
    Study

    chickenn: not reported in source

    Developing chick embryos with influenza infection
    Outcome group
    Antiviral activity · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In experiments on developing chick embryos, none of the peptide preparations under study had any influence on the infection caused by the viruses of both hypes.
    1 context sentence
    Summary · context
    Four peptide preparations were used: two medicinal peptide preparations of the thymus (thymalin and thymogen) and peptide preparations obtained from the tracheal mucosa (PTM) and lung parenchyma (PLP) of calves according to the technology used for obtaining thymalin.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In developing chick embryos, thymogen did not affect type B influenza infection.

    In plain wordsIn chick embryos, thymogen did not affect type B influenza infection.

    Peptide
    Thymogen (oglufanide)
    Outcome
    No significant changeType B influenza infection in embryos
    Study

    chickenn: not reported in source

    Developing chick embryos with influenza infection
    Outcome group
    Antiviral activity · Infection
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In experiments on developing chick embryos, none of the peptide preparations under study had any influence on the infection caused by the viruses of both hypes.
    1 context sentence
    Summary · context
    Four peptide preparations were used: two medicinal peptide preparations of the thymus (thymalin and thymogen) and peptide preparations obtained from the tracheal mucosa (PTM) and lung parenchyma (PLP) of calves according to the technology used for obtaining thymalin.

Studies that did not test the peptide alone2

In this study, Thymalin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymalin.

  1. 10AnimalNot a test of Thymalin aloneAnimal study (in vivo)Efficacy outcome

    In mice with type B influenza, thymus preparations including thymalin had no influence on death rate.

    In plain wordsIn mice with type B influenza, thymus preparations including thymalin did not change death rate.

    Peptide
    Thymalin
    Outcome
    No significant changeDeath rate with type B influenza
    Study

    mousen: not reported in source

    Experimental influenza infection
    Outcome group
    Mortality · Infection

    Source sentences

    Summary
    In case of type B virus, adapromin and PTM were found to produce a similar effect, while the preparations of the thymus and PLP had no influence on the death rate of the animals.
    2 context sentences
    Summary · context
    To evaluate the possible antiviral activity of a number of peptide bioregulators, an acute influenza infection was induced in developing chick embryos and mice.
    Summary · context
    In experiments on mice, the preparations were introduced 24 hours and 1 hour before and 24, 48 and 72 hours after intranasal challenge.

    In this study, Thymalin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymalin.

  2. 11AnimalNot a test of Thymalin aloneAnimal study (in vivo)Efficacy outcome

    In developing chick embryos, pooled peptide preparations including thymalin had no influence on infection with either influenza virus type.

    In plain wordsIn chick embryos, pooled peptide preparations including thymalin did not change infection with either influenza virus type.

    Peptide
    Thymalin
    Outcome
    No significant changeInfluenza infection in chick embryos
    Study

    chickenn: not reported in source

    Developing chick embryos with influenza infection
    Outcome group
    Antiviral activity · Infection

    Source sentences

    Summary
    In experiments on developing chick embryos, none of the peptide preparations under study had any influence on the infection caused by the viruses of both hypes.
    1 context sentence
    Summary · context
    Four peptide preparations were used: two medicinal peptide preparations of the thymus (thymalin and thymogen) and peptide preparations obtained from the tracheal mucosa (PTM) and lung parenchyma (PLP) of calves according to the technology used for obtaining thymalin.

    In this study, Thymalin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymalin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 12:50 UTC

    Study data updated · source update from Europe PMC

  2. Version 2

    14 Oct 2026, 05:02 UTC

    Study results updated

  3. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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