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Study · Animal study (in vivo) · guinea pig · 1993

6 results

[The effect of thymalin on the development of sensitization with a soluble microbial antigen and on the phenotypic composition of lymphocyte subpopulations in the organs of immunity].

Sukhodoeva GS, Shamsutdinova GS, Dobritsa VP, Ospanova EN, Lukpanova ShZ

Zhurnal mikrobiologii, epidemiologii i immunobiologii1 Jan 1993

PMID8067074 (opens in a new tab)PepBankPUB-08067074
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Activity measurement

    In immunized guinea pigs, thymalin stimulated allergization.

    In plain wordsIn guinea pigs immunized with bacterial antigen, thymalin stimulated allergic sensitization.

    Peptide
    Thymalin
    Outcome
    IncreaseAllergization
    Study

    guinea pign: not reported in source

    Guinea pigs immunized with Haemophilus influenzae antigen
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The stimulating influence of thymalin on the allergization of the body, changes in the lymphocyte subpopulations, as well as the possibility of the development of allergic reactions to thymalin, were established.
    1 context sentence
    Summary · context
    The influence of thymalin on the formation of specific allergy and the distribution of immunocompetent cells in the immunity organs of guinea pigs immunized with Haemophilus influenzae antigen was studied.
  2. 02AnimalAnimal study (in vivo)Activity measurement

    In immunized guinea pigs, thymalin changed lymphocyte subpopulations.

    In plain wordsIn guinea pigs immunized with bacterial antigen, thymalin changed lymphocyte subpopulations.

    Peptide
    Thymalin
    Outcome
    Not applicableLymphocyte subpopulation changes
    Study

    guinea pign: not reported in source

    Guinea pigs immunized with Haemophilus influenzae antigen
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The stimulating influence of thymalin on the allergization of the body, changes in the lymphocyte subpopulations, as well as the possibility of the development of allergic reactions to thymalin, were established.
    1 context sentence
    Summary · context
    The influence of thymalin on the formation of specific allergy and the distribution of immunocompetent cells in the immunity organs of guinea pigs immunized with Haemophilus influenzae antigen was studied.
  3. 03AnimalAnimal study (in vivo)Safety outcome

    In immunized guinea pigs, the study established the possibility of allergic reactions to thymalin.

    In plain wordsIn guinea pigs immunized with bacterial antigen, the study found that allergic reactions to thymalin were possible.

    Peptide
    Thymalin
    Outcome
    Not applicablePossible allergic reactions to thymalin
    Study

    guinea pign: not reported in source

    Guinea pigs immunized with Haemophilus influenzae antigen
    Outcome group
    Adverse events · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The stimulating influence of thymalin on the allergization of the body, changes in the lymphocyte subpopulations, as well as the possibility of the development of allergic reactions to thymalin, were established.
    1 context sentence
    Summary · context
    The influence of thymalin on the formation of specific allergy and the distribution of immunocompetent cells in the immunity organs of guinea pigs immunized with Haemophilus influenzae antigen was studied.
  4. 04AnimalAnimal study (in vivo)Activity measurement

    In immunized guinea pigs, multiple thymalin injections stimulated specific microbial allergy more than a single injection.

    In plain wordsIn guinea pigs, multiple thymalin injections stimulated specific microbial allergy more than a single injection.

    Peptide
    Thymalin
    Outcome
    IncreaseSpecific microbial allergy formation
    Study

    guinea pign: not reported in source

    Guinea pigs immunized with Haemophilus influenzae antigen
    Comparator
    Single thymalin injection
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · injectionAs given in this study (guinea pig).

    Source sentences

    Summary
    Multiple injections of thymalin produced a stronger stimulating effect on the formation of specific microbial allergy and on the content of T- and B-lymphocytes than a single injection of the preparation.
    1 context sentence
    Summary · context
    The influence of thymalin on the formation of specific allergy and the distribution of immunocompetent cells in the immunity organs of guinea pigs immunized with Haemophilus influenzae antigen was studied.
  5. 05AnimalAnimal study (in vivo)Activity measurement

    In immunized guinea pigs, multiple thymalin injections stimulated T-lymphocyte content more than a single injection.

    In plain wordsIn guinea pigs, multiple thymalin injections increased T-lymphocyte content more than a single injection.

    Peptide
    Thymalin
    Outcome
    IncreaseT-lymphocyte content
    Study

    guinea pign: not reported in source

    Guinea pigs immunized with Haemophilus influenzae antigen
    Comparator
    Single thymalin injection
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · injectionAs given in this study (guinea pig).

    Source sentences

    Summary
    Multiple injections of thymalin produced a stronger stimulating effect on the formation of specific microbial allergy and on the content of T- and B-lymphocytes than a single injection of the preparation.
    1 context sentence
    Summary · context
    The influence of thymalin on the formation of specific allergy and the distribution of immunocompetent cells in the immunity organs of guinea pigs immunized with Haemophilus influenzae antigen was studied.
  6. 06AnimalAnimal study (in vivo)Activity measurement

    In immunized guinea pigs, multiple thymalin injections stimulated B-lymphocyte content more than a single injection.

    In plain wordsIn guinea pigs, multiple thymalin injections increased B-lymphocyte content more than a single injection.

    Peptide
    Thymalin
    Outcome
    IncreaseB-lymphocyte content
    Study

    guinea pign: not reported in source

    Guinea pigs immunized with Haemophilus influenzae antigen
    Comparator
    Single thymalin injection
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · injectionAs given in this study (guinea pig).

    Source sentences

    Summary
    Multiple injections of thymalin produced a stronger stimulating effect on the formation of specific microbial allergy and on the content of T- and B-lymphocytes than a single injection of the preparation.
    1 context sentence
    Summary · context
    The influence of thymalin on the formation of specific allergy and the distribution of immunocompetent cells in the immunity organs of guinea pigs immunized with Haemophilus influenzae antigen was studied.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

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