Calcium- and calmodulin-independent modulation of calmodulin-sensitive hypothalamic cyclic nucleotide phosphodiesterase activity by the (11-19) fragment of thymosin beta 4.

Galoyan AA, Abrahamian GE, Chailyan SG, Hashim GA, Lajtha A

Neurochemical research1 Apr 1994

PMID8065501DOI10.1007/bf00967323PepBankPUB-08065501

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone6

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

01LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cell-free)Activity measurement
In a hypothalamic enzyme preparation, the (11-19) fragment of thymosin beta‑4 stimulated phosphodiesterase activity even without calcium and calmodulin.
In plain wordsIn lab tests, a fragment of thymosin beta‑4 raised the activity of a brain enzyme even without calcium and calmodulin.
Peptide
Thymosin beta-4 (human)
Outcome
IncreasePhosphodiesterase activity without calcium and calmodulin
Study
n: not reported in source
Hypothalamic cyclic nucleotide phosphodiesterase
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
A fragment (11-19) of thymosin beta 4 was found to stimulate phosphodiesterase activity even in the absence of calcium and calmodulin.
1 context sentence(design, population, supporting numbers)
Title · context
Calcium- and calmodulin-independent modulation of calmodulin-sensitive hypothalamic cyclic nucleotide phosphodiesterase activity by the (11-19) fragment of thymosin beta 4.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-0806550101
02LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cell-free)Activity measurement
In a hypothalamic enzyme preparation, half-maximal activation of phosphodiesterase by the thymosin beta‑4 (11-19) fragment occurred with 10 nM peptide.
In plain wordsIn lab tests, 10 nM of a thymosin beta‑4 fragment gave half of the maximal activation of a brain enzyme.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseHalf-maximal phosphodiesterase activation concentration
Study
n: not reported in source
Hypothalamic cyclic nucleotide phosphodiesterase
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Measurements
Half-maximal activation
10 nM
(11-19) fragment
Source sentences
Summary
Half-maximal enzyme activation occurred with 10 nM peptide
1 context sentence(design, population, supporting numbers)
Title · context
Calcium- and calmodulin-independent modulation of calmodulin-sensitive hypothalamic cyclic nucleotide phosphodiesterase activity by the (11-19) fragment of thymosin beta 4.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-0806550102
03LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cell-free)Mechanism
In a hypothalamic enzyme preparation, phospholipids such as phosphatidylserine further increased the activation of phosphodiesterase by the thymosin beta‑4 (11-19) fragment.
In plain wordsIn lab tests, phospholipids raised the enzyme activation by a thymosin beta‑4 fragment even more.
Peptide
Thymosin beta-4 (human)
Outcome
IncreasePhosphodiesterase activation with phospholipids
Study
n: not reported in source
Hypothalamic cyclic nucleotide phosphodiesterase
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
Half-maximal enzyme activation occurred with 10 nM peptide, and was further increased by phospholipids such as phosphatidylserine.
1 context sentence(design, population, supporting numbers)
Title · context
Calcium- and calmodulin-independent modulation of calmodulin-sensitive hypothalamic cyclic nucleotide phosphodiesterase activity by the (11-19) fragment of thymosin beta 4.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-0806550103
04LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cell-free)Mechanism
In a hypothalamic enzyme preparation, the thymosin beta‑4 (11-19) fragment increased the Vmax of cAMP degradation.
In plain wordsIn lab tests, a thymosin beta‑4 fragment raised the top speed at which a brain enzyme broke down cAMP.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseVmax of cAMP degradation
Study
n: not reported in source
Hypothalamic cyclic nucleotide phosphodiesterase
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
The mechanism of stimulation is an increase in the Vmax of cAMP degradation
1 context sentence(design, population, supporting numbers)
Title · context
Calcium- and calmodulin-independent modulation of calmodulin-sensitive hypothalamic cyclic nucleotide phosphodiesterase activity by the (11-19) fragment of thymosin beta 4.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-0806550104
05LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cell-free)Mechanism
In a hypothalamic enzyme preparation, the thymosin beta‑4 (11-19) fragment did not substantially change the Km of cAMP degradation for the substrate.
In plain wordsIn lab tests, a thymosin beta‑4 fragment did not substantially change the substrate Km of a brain enzyme.
Peptide
Thymosin beta-4 (human)
Outcome
No significant changeKm of cAMP degradation
Study
n: not reported in source
Hypothalamic cyclic nucleotide phosphodiesterase
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
without a substantial change in the Km for the substrate.
1 context sentence(design, population, supporting numbers)
Title · context
Calcium- and calmodulin-independent modulation of calmodulin-sensitive hypothalamic cyclic nucleotide phosphodiesterase activity by the (11-19) fragment of thymosin beta 4.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-0806550105
06LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cell-free)Activity measurement
In a hypothalamic enzyme preparation with calcium ions and calmodulin, the thymosin beta‑4 (11-19) fragment also stimulated phosphodiesterase activity.
In plain wordsIn lab tests, a thymosin beta‑4 fragment also raised brain enzyme activity when calcium and calmodulin were present.
Peptide
Thymosin beta-4 (human)
Outcome
IncreasePhosphodiesterase activity with calcium and calmodulin
Study
n: not reported in source
Hypothalamic cyclic nucleotide phosphodiesterase
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
In the presence of calcium ions and calmodulin the peptide was also stimulatory.
1 context sentence(design, population, supporting numbers)
Title · context
Calcium- and calmodulin-independent modulation of calmodulin-sensitive hypothalamic cyclic nucleotide phosphodiesterase activity by the (11-19) fragment of thymosin beta 4.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-0806550106

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 01:52 UTC
Study results updated
Version 1
12 Oct 2026, 18:17 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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