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Study · In vitro (cells) · ovine receptor · 1994

2 results

Cloning and expression of a new member of the melanocyte-stimulating hormone receptor family.

Barrett P, MacDonald A, Helliwell R, Davidson G, Morgan P

Journal of molecular endocrinology1 Apr 1994Cited by 64 (Europe PMC)

PMID8060485 (opens in a new tab)DOI10.1677/jme.0.0120203 (opens in a new tab)PepBankPUB-08060485
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In Cos7 cells expressing a novel ovine receptor, NDP-MSH bound the receptor with high affinity.

    In plain wordsIn lab tests on cells, NDP-MSH bound a newly found sheep receptor strongly.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    Not applicableNDP-MSH binding to the new receptor
    Study

    ovine receptorn: not reported in source

    Cos7 cells expressing a novel ovine melanocortin receptor
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    When this receptor was expressed in Cos7 cells, it was able to bind a potent analogue of alpha-MSH, [Nle4,D-Phe7]-alpha-MSH (NDP-MSH), with high affinity.
  2. 02LabIn vitro (cells)Activity measurement

    In Cos7 cells expressing a novel ovine receptor, NDP-MSH was the most potent displacer of binding, ahead of alpha-MSH, ACTH and beta-MSH.

    In plain wordsIn lab tests on cells, NDP-MSH competed for the new receptor more strongly than alpha-MSH, ACTH and beta-MSH.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    Not applicablePotency order of binding displacement
    Study

    ovine receptorn: not reported in source

    Cos7 cells expressing a novel ovine melanocortin receptor
    Comparator
    alpha-MSH, ACTH, beta-MSH
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    This binding could be displaced by pro-opiomelanocortin-derived and related peptides, with the order of potency NDP-MSH > alpha-MSH = ACTH > beta-MSH and with no effect of gamma-MSH, delta-MSH or beta-endorphin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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