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Study · Non-randomized trial · n = 12 · 1994

4 results

[Short-term comparison of the treatment of precocious puberty with 2 different LHRH antagonists (buserelin and long-acting triptorelin). An endocrinologic and echographic study].

Cicognani A, Cacciari E, Balsamo A, Cassio A, Papasodero A, Bellizzi M, Guacci P, Zappulla F

La Pediatria medica e chirurgica : Medical and surgical pediatrics1 Jan 1994

PMID8029088 (opens in a new tab)PepBankPUB-08029088
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In children with early puberty, FSH decreased significantly during triptorelin treatment.

    In plain wordsIn children with early puberty, FSH decreased during triptorelin treatment.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseFSH
    Study

    n = 12

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    3.75 mg every 4 weeks · intramuscular · 2 monthsAs given in this study (human).

    Source sentences

    Summary
    The results indicate that while in both groups FSH values decreased significantly already from the last month of treatment, patients treated with Triptorelin showed a later LH decrease (significant only after 2 months of treatment).
    1 context sentence
    Summary · context
    6 patients started with Buserelin and 6 with Triptorelin. The therapeutic regimen was crossed over after 2 months of treatment and 2 more months of treatment withdrawal.
  2. 02HumanNon-randomized trialEfficacy outcome

    In children with early puberty, LH decreased significantly only after two months of triptorelin treatment.

    In plain wordsIn children with early puberty, LH decreased significantly only after two months of triptorelin treatment.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseLH
    Study

    n = 12

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    3.75 mg every 4 weeks · intramuscular · 2 monthsAs given in this study (human).

    Source sentences

    Summary
    The results indicate that while in both groups FSH values decreased significantly already from the last month of treatment, patients treated with Triptorelin showed a later LH decrease (significant only after 2 months of treatment).
    1 context sentence
    Summary · context
    6 patients started with Buserelin and 6 with Triptorelin. The therapeutic regimen was crossed over after 2 months of treatment and 2 more months of treatment withdrawal.
  3. 03HumanNon-randomized trialEfficacy outcome

    In children with early puberty, pelvic structure volume decreased with triptorelin and not with buserelin.

    In plain wordsIn children with early puberty, pelvic organ volume got smaller with triptorelin but not with buserelin.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreasePelvic structure volume
    Study

    n = 12

    Comparator
    Buserelin
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    3.75 mg every 4 weeks · intramuscular · 2 monthsAs given in this study (human).

    Source sentences

    Summary
    A decrease of pelvic structures volume was however evident only in patients treated with Triptorelin.
    1 context sentence
    Summary · context
    6 patients started with Buserelin and 6 with Triptorelin. The therapeutic regimen was crossed over after 2 months of treatment and 2 more months of treatment withdrawal.
  4. 04HumanNon-randomized trialEfficacy outcome

    In children with early puberty, estradiol fell nonsignificantly after triptorelin treatment.

    In plain wordsIn children with early puberty, estradiol levels went down a little with triptorelin, but not by a significant amount.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changeEstradiol
    Study

    n = 12

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    3.75 mg every 4 weeks · intramuscular · 2 monthsAs given in this study (human).

    Source sentences

    Summary
    After 2 months of treatment estradiol levels lowered (but not significantly) in both group.
    1 context sentence
    Summary · context
    6 patients started with Buserelin and 6 with Triptorelin. The therapeutic regimen was crossed over after 2 months of treatment and 2 more months of treatment withdrawal.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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