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Study · Randomized controlled trial · n = 60 · 1994

18 results

Prospective randomized study of D-Trp6-LHRH versus buserelin in long desensitization protocols for medically assisted conception cycles.

Gianaroli L, Ferraretti AP, Feliciani E, Tabanelli C, Magli C, Fortini D

Human reproduction (Oxford, England)1 Feb 1994Cited by 13 (Europe PMC)

PMID8027275 (opens in a new tab)DOI10.1093/oxfordjournals.humrep.a138485 (opens in a new tab)PepBankPUB-08027275
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study18

18 results from studies that gave the peptide. 18 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In assisted conception, ovarian response was similar across protocols, except for premature luteinization in two triptorelin protocol B patients.

    In plain wordsIn assisted conception, ovarian response was similar with triptorelin protocol B and buserelin, except for premature luteinization.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changeOvarian response, protocol B versus A
    Study

    n = 60

    Comparator
    Buserelin protocol A
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    3.75 mg long-acting single dose · injectionAs given in this study (human).

    Source sentences

    Summary
    There was no difference in the ovarian response to exogenous gonadotrophin stimulation, except for the presence of premature luteinization in two patients in group B.
    4 context sentences
    Summary · context
    In a prospective, controlled, randomized study where two different agonists were used, we compared three different long desensitization protocols for induction of multiple follicular growth in medically assisted conception cycles.
    Summary · context
    In protocol A, 30 patients were injected with buserelin twice a day for 15 days prior to ovarian stimulation until human chorionic gonadotrophin (HCG) administration.
    Summary · context
    In protocol B, 30 patients were injected with a single dose of long acting Triptorelin (3.75 mg) 15 days before the ovarian stimulation onset.
    Summary · context
    In protocol C, 30 patients were injected with the long acting Triptorelin 4 weeks before ovarian stimulation followed by daily administration of 0.1 mg of the same agonist until HCG injection.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In assisted conception, ovarian response did not differ between triptorelin protocol C and buserelin protocol A.

    In plain wordsIn assisted conception, ovarian response was similar with triptorelin protocol C and buserelin.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changeOvarian response, protocol C versus A
    Study

    n = 60

    Comparator
    Buserelin protocol A
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Long-acting triptorelin followed by 0.1 mg daily · injectionAs given in this study (human).

    Source sentences

    Summary
    There was no difference in the ovarian response to exogenous gonadotrophin stimulation, except for the presence of premature luteinization in two patients in group B.
    4 context sentences
    Summary · context
    In a prospective, controlled, randomized study where two different agonists were used, we compared three different long desensitization protocols for induction of multiple follicular growth in medically assisted conception cycles.
    Summary · context
    In protocol A, 30 patients were injected with buserelin twice a day for 15 days prior to ovarian stimulation until human chorionic gonadotrophin (HCG) administration.
    Summary · context
    In protocol B, 30 patients were injected with a single dose of long acting Triptorelin (3.75 mg) 15 days before the ovarian stimulation onset.
    Summary · context
    In protocol C, 30 patients were injected with the long acting Triptorelin 4 weeks before ovarian stimulation followed by daily administration of 0.1 mg of the same agonist until HCG injection.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In assisted conception, ovarian response was similar across protocols, except for premature luteinization in two triptorelin protocol B patients.

    In plain wordsIn assisted conception, ovarian response was similar across triptorelin protocols, except for premature luteinization in protocol B.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changeOvarian response, protocol B versus C
    Study

    n = 60

    Comparator
    Triptorelin protocol C
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    3.75 mg long-acting single dose · injectionAs given in this study (human).

    Source sentences

    Summary
    There was no difference in the ovarian response to exogenous gonadotrophin stimulation, except for the presence of premature luteinization in two patients in group B.
    4 context sentences
    Summary · context
    In a prospective, controlled, randomized study where two different agonists were used, we compared three different long desensitization protocols for induction of multiple follicular growth in medically assisted conception cycles.
    Summary · context
    In protocol A, 30 patients were injected with buserelin twice a day for 15 days prior to ovarian stimulation until human chorionic gonadotrophin (HCG) administration.
    Summary · context
    In protocol B, 30 patients were injected with a single dose of long acting Triptorelin (3.75 mg) 15 days before the ovarian stimulation onset.
    Summary · context
    In protocol C, 30 patients were injected with the long acting Triptorelin 4 weeks before ovarian stimulation followed by daily administration of 0.1 mg of the same agonist until HCG injection.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In assisted conception, triptorelin protocol B yielded significantly fewer mature oocytes than buserelin protocol A.

    In plain wordsIn assisted conception, triptorelin protocol B yielded fewer mature eggs than buserelin.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseMature oocytes, protocol B versus A
    Study

    n = 60

    Comparator
    Buserelin protocol A
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    3.75 mg long-acting single dose · injectionAs given in this study (human).

    Source sentences

    Summary
    A significantly higher number of mature oocytes was collected from patients with protocol A;
    4 context sentences
    Summary · context
    In a prospective, controlled, randomized study where two different agonists were used, we compared three different long desensitization protocols for induction of multiple follicular growth in medically assisted conception cycles.
    Summary · context
    In protocol A, 30 patients were injected with buserelin twice a day for 15 days prior to ovarian stimulation until human chorionic gonadotrophin (HCG) administration.
    Summary · context
    In protocol B, 30 patients were injected with a single dose of long acting Triptorelin (3.75 mg) 15 days before the ovarian stimulation onset.
    Summary · context
    In protocol C, 30 patients were injected with the long acting Triptorelin 4 weeks before ovarian stimulation followed by daily administration of 0.1 mg of the same agonist until HCG injection.
  5. 05HumanRandomized controlled trialEfficacy outcome

    In assisted conception, triptorelin protocol C yielded significantly fewer mature oocytes than buserelin protocol A.

    In plain wordsIn assisted conception, triptorelin protocol C yielded fewer mature eggs than buserelin.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseMature oocytes, protocol C versus A
    Study

    n = 60

    Comparator
    Buserelin protocol A
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Long-acting triptorelin followed by 0.1 mg daily · injectionAs given in this study (human).

    Source sentences

    Summary
    A significantly higher number of mature oocytes was collected from patients with protocol A;
    4 context sentences
    Summary · context
    In a prospective, controlled, randomized study where two different agonists were used, we compared three different long desensitization protocols for induction of multiple follicular growth in medically assisted conception cycles.
    Summary · context
    In protocol A, 30 patients were injected with buserelin twice a day for 15 days prior to ovarian stimulation until human chorionic gonadotrophin (HCG) administration.
    Summary · context
    In protocol B, 30 patients were injected with a single dose of long acting Triptorelin (3.75 mg) 15 days before the ovarian stimulation onset.
    Summary · context
    In protocol C, 30 patients were injected with the long acting Triptorelin 4 weeks before ovarian stimulation followed by daily administration of 0.1 mg of the same agonist until HCG injection.
  6. 06HumanRandomized controlled trialEfficacy outcome

    In assisted conception, fertilization rates did not differ significantly between triptorelin protocol B and buserelin protocol A.

    In plain wordsIn assisted conception, fertilization rates were similar with triptorelin protocol B and buserelin.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changeFertilization rate, protocol B versus A
    Study

    n = 60

    Comparator
    Buserelin protocol A
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    3.75 mg long-acting single dose · injectionAs given in this study (human).

    Source sentences

    Summary
    however, the fertilization and cleavage rate demonstrated no significant difference among the three groups of patients.
    4 context sentences
    Summary · context
    In a prospective, controlled, randomized study where two different agonists were used, we compared three different long desensitization protocols for induction of multiple follicular growth in medically assisted conception cycles.
    Summary · context
    In protocol A, 30 patients were injected with buserelin twice a day for 15 days prior to ovarian stimulation until human chorionic gonadotrophin (HCG) administration.
    Summary · context
    In protocol B, 30 patients were injected with a single dose of long acting Triptorelin (3.75 mg) 15 days before the ovarian stimulation onset.
    Summary · context
    In protocol C, 30 patients were injected with the long acting Triptorelin 4 weeks before ovarian stimulation followed by daily administration of 0.1 mg of the same agonist until HCG injection.
  7. 07HumanRandomized controlled trialEfficacy outcome

    In assisted conception, fertilization rates did not differ significantly between triptorelin protocol C and buserelin protocol A.

    In plain wordsIn assisted conception, fertilization rates were similar with triptorelin protocol C and buserelin.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changeFertilization rate, protocol C versus A
    Study

    n = 60

    Comparator
    Buserelin protocol A
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Long-acting triptorelin followed by 0.1 mg daily · injectionAs given in this study (human).

    Source sentences

    Summary
    however, the fertilization and cleavage rate demonstrated no significant difference among the three groups of patients.
    4 context sentences
    Summary · context
    In a prospective, controlled, randomized study where two different agonists were used, we compared three different long desensitization protocols for induction of multiple follicular growth in medically assisted conception cycles.
    Summary · context
    In protocol A, 30 patients were injected with buserelin twice a day for 15 days prior to ovarian stimulation until human chorionic gonadotrophin (HCG) administration.
    Summary · context
    In protocol B, 30 patients were injected with a single dose of long acting Triptorelin (3.75 mg) 15 days before the ovarian stimulation onset.
    Summary · context
    In protocol C, 30 patients were injected with the long acting Triptorelin 4 weeks before ovarian stimulation followed by daily administration of 0.1 mg of the same agonist until HCG injection.
  8. 08HumanRandomized controlled trialEfficacy outcome

    In assisted conception, fertilization rates did not differ significantly between triptorelin protocols B and C.

    In plain wordsIn assisted conception, fertilization rates were similar between triptorelin protocols B and C.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changeFertilization rate, protocol B versus C
    Study

    n = 60

    Comparator
    Triptorelin protocol C
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    3.75 mg long-acting single dose · injectionAs given in this study (human).

    Source sentences

    Summary
    however, the fertilization and cleavage rate demonstrated no significant difference among the three groups of patients.
    4 context sentences
    Summary · context
    In a prospective, controlled, randomized study where two different agonists were used, we compared three different long desensitization protocols for induction of multiple follicular growth in medically assisted conception cycles.
    Summary · context
    In protocol A, 30 patients were injected with buserelin twice a day for 15 days prior to ovarian stimulation until human chorionic gonadotrophin (HCG) administration.
    Summary · context
    In protocol B, 30 patients were injected with a single dose of long acting Triptorelin (3.75 mg) 15 days before the ovarian stimulation onset.
    Summary · context
    In protocol C, 30 patients were injected with the long acting Triptorelin 4 weeks before ovarian stimulation followed by daily administration of 0.1 mg of the same agonist until HCG injection.
  9. 09HumanRandomized controlled trialEfficacy outcome

    In assisted conception, cleavage rates did not differ significantly between triptorelin protocol B and buserelin protocol A.

    In plain wordsIn assisted conception, embryo cleavage rates were similar with triptorelin protocol B and buserelin.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changeCleavage rate, protocol B versus A
    Study

    n = 60

    Comparator
    Buserelin protocol A
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    3.75 mg long-acting single dose · injectionAs given in this study (human).

    Source sentences

    Summary
    however, the fertilization and cleavage rate demonstrated no significant difference among the three groups of patients.
    4 context sentences
    Summary · context
    In a prospective, controlled, randomized study where two different agonists were used, we compared three different long desensitization protocols for induction of multiple follicular growth in medically assisted conception cycles.
    Summary · context
    In protocol A, 30 patients were injected with buserelin twice a day for 15 days prior to ovarian stimulation until human chorionic gonadotrophin (HCG) administration.
    Summary · context
    In protocol B, 30 patients were injected with a single dose of long acting Triptorelin (3.75 mg) 15 days before the ovarian stimulation onset.
    Summary · context
    In protocol C, 30 patients were injected with the long acting Triptorelin 4 weeks before ovarian stimulation followed by daily administration of 0.1 mg of the same agonist until HCG injection.
  10. 10HumanRandomized controlled trialEfficacy outcome

    In assisted conception, cleavage rates did not differ significantly between triptorelin protocol C and buserelin protocol A.

    In plain wordsIn assisted conception, embryo cleavage rates were similar with triptorelin protocol C and buserelin.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changeCleavage rate, protocol C versus A
    Study

    n = 60

    Comparator
    Buserelin protocol A
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Long-acting triptorelin followed by 0.1 mg daily · injectionAs given in this study (human).

    Source sentences

    Summary
    however, the fertilization and cleavage rate demonstrated no significant difference among the three groups of patients.
    4 context sentences
    Summary · context
    In a prospective, controlled, randomized study where two different agonists were used, we compared three different long desensitization protocols for induction of multiple follicular growth in medically assisted conception cycles.
    Summary · context
    In protocol A, 30 patients were injected with buserelin twice a day for 15 days prior to ovarian stimulation until human chorionic gonadotrophin (HCG) administration.
    Summary · context
    In protocol B, 30 patients were injected with a single dose of long acting Triptorelin (3.75 mg) 15 days before the ovarian stimulation onset.
    Summary · context
    In protocol C, 30 patients were injected with the long acting Triptorelin 4 weeks before ovarian stimulation followed by daily administration of 0.1 mg of the same agonist until HCG injection.
  11. 11HumanRandomized controlled trialEfficacy outcome

    In assisted conception, cleavage rates did not differ significantly between triptorelin protocols B and C.

    In plain wordsIn assisted conception, embryo cleavage rates were similar between triptorelin protocols B and C.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changeCleavage rate, protocol B versus C
    Study

    n = 60

    Comparator
    Triptorelin protocol C
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    3.75 mg long-acting single dose · injectionAs given in this study (human).

    Source sentences

    Summary
    however, the fertilization and cleavage rate demonstrated no significant difference among the three groups of patients.
    4 context sentences
    Summary · context
    In a prospective, controlled, randomized study where two different agonists were used, we compared three different long desensitization protocols for induction of multiple follicular growth in medically assisted conception cycles.
    Summary · context
    In protocol A, 30 patients were injected with buserelin twice a day for 15 days prior to ovarian stimulation until human chorionic gonadotrophin (HCG) administration.
    Summary · context
    In protocol B, 30 patients were injected with a single dose of long acting Triptorelin (3.75 mg) 15 days before the ovarian stimulation onset.
    Summary · context
    In protocol C, 30 patients were injected with the long acting Triptorelin 4 weeks before ovarian stimulation followed by daily administration of 0.1 mg of the same agonist until HCG injection.
  12. 12HumanRandomized controlled trialEfficacy outcome

    In assisted conception, ongoing pregnancy rates per cycle were very similar with triptorelin protocol B and buserelin protocol A.

    In plain wordsIn assisted conception, ongoing pregnancy rates were similar with triptorelin protocol B and buserelin.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changeOngoing pregnancy rate, protocol B versus A
    Study

    n = 60

    Comparator
    Buserelin protocol A
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    3.75 mg long-acting single dose · injectionAs given in this study (human).

    Source sentences

    Summary
    The ongoing pregnancy rate and the implantation rate per treatment cycle were very similar in the three study groups.
    4 context sentences
    Summary · context
    In a prospective, controlled, randomized study where two different agonists were used, we compared three different long desensitization protocols for induction of multiple follicular growth in medically assisted conception cycles.
    Summary · context
    In protocol A, 30 patients were injected with buserelin twice a day for 15 days prior to ovarian stimulation until human chorionic gonadotrophin (HCG) administration.
    Summary · context
    In protocol B, 30 patients were injected with a single dose of long acting Triptorelin (3.75 mg) 15 days before the ovarian stimulation onset.
    Summary · context
    In protocol C, 30 patients were injected with the long acting Triptorelin 4 weeks before ovarian stimulation followed by daily administration of 0.1 mg of the same agonist until HCG injection.
  13. 13HumanRandomized controlled trialEfficacy outcome

    In assisted conception, ongoing pregnancy rates per cycle were very similar with triptorelin protocol C and buserelin protocol A.

    In plain wordsIn assisted conception, ongoing pregnancy rates were similar with triptorelin protocol C and buserelin.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changeOngoing pregnancy rate, protocol C versus A
    Study

    n = 60

    Comparator
    Buserelin protocol A
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Long-acting triptorelin followed by 0.1 mg daily · injectionAs given in this study (human).

    Source sentences

    Summary
    The ongoing pregnancy rate and the implantation rate per treatment cycle were very similar in the three study groups.
    4 context sentences
    Summary · context
    In a prospective, controlled, randomized study where two different agonists were used, we compared three different long desensitization protocols for induction of multiple follicular growth in medically assisted conception cycles.
    Summary · context
    In protocol A, 30 patients were injected with buserelin twice a day for 15 days prior to ovarian stimulation until human chorionic gonadotrophin (HCG) administration.
    Summary · context
    In protocol B, 30 patients were injected with a single dose of long acting Triptorelin (3.75 mg) 15 days before the ovarian stimulation onset.
    Summary · context
    In protocol C, 30 patients were injected with the long acting Triptorelin 4 weeks before ovarian stimulation followed by daily administration of 0.1 mg of the same agonist until HCG injection.
  14. 14HumanRandomized controlled trialEfficacy outcome

    In assisted conception, ongoing pregnancy rates per cycle were very similar with triptorelin protocols B and C.

    In plain wordsIn assisted conception, ongoing pregnancy rates were similar between triptorelin protocols B and C.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changeOngoing pregnancy rate, protocol B versus C
    Study

    n = 60

    Comparator
    Triptorelin protocol C
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    3.75 mg long-acting single dose · injectionAs given in this study (human).

    Source sentences

    Summary
    The ongoing pregnancy rate and the implantation rate per treatment cycle were very similar in the three study groups.
    4 context sentences
    Summary · context
    In a prospective, controlled, randomized study where two different agonists were used, we compared three different long desensitization protocols for induction of multiple follicular growth in medically assisted conception cycles.
    Summary · context
    In protocol A, 30 patients were injected with buserelin twice a day for 15 days prior to ovarian stimulation until human chorionic gonadotrophin (HCG) administration.
    Summary · context
    In protocol B, 30 patients were injected with a single dose of long acting Triptorelin (3.75 mg) 15 days before the ovarian stimulation onset.
    Summary · context
    In protocol C, 30 patients were injected with the long acting Triptorelin 4 weeks before ovarian stimulation followed by daily administration of 0.1 mg of the same agonist until HCG injection.
  15. 15HumanRandomized controlled trialEfficacy outcome

    In assisted conception, implantation rates per cycle were very similar with triptorelin protocol B and buserelin protocol A.

    In plain wordsIn assisted conception, implantation rates were similar with triptorelin protocol B and buserelin.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changeImplantation rate, protocol B versus A
    Study

    n = 60

    Comparator
    Buserelin protocol A
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    3.75 mg long-acting single dose · injectionAs given in this study (human).

    Source sentences

    Summary
    The ongoing pregnancy rate and the implantation rate per treatment cycle were very similar in the three study groups.
    4 context sentences
    Summary · context
    In a prospective, controlled, randomized study where two different agonists were used, we compared three different long desensitization protocols for induction of multiple follicular growth in medically assisted conception cycles.
    Summary · context
    In protocol A, 30 patients were injected with buserelin twice a day for 15 days prior to ovarian stimulation until human chorionic gonadotrophin (HCG) administration.
    Summary · context
    In protocol B, 30 patients were injected with a single dose of long acting Triptorelin (3.75 mg) 15 days before the ovarian stimulation onset.
    Summary · context
    In protocol C, 30 patients were injected with the long acting Triptorelin 4 weeks before ovarian stimulation followed by daily administration of 0.1 mg of the same agonist until HCG injection.
  16. 16HumanRandomized controlled trialEfficacy outcome

    In assisted conception, implantation rates per cycle were very similar with triptorelin protocol C and buserelin protocol A.

    In plain wordsIn assisted conception, implantation rates were similar with triptorelin protocol C and buserelin.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changeImplantation rate, protocol C versus A
    Study

    n = 60

    Comparator
    Buserelin protocol A
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Long-acting triptorelin followed by 0.1 mg daily · injectionAs given in this study (human).

    Source sentences

    Summary
    The ongoing pregnancy rate and the implantation rate per treatment cycle were very similar in the three study groups.
    4 context sentences
    Summary · context
    In a prospective, controlled, randomized study where two different agonists were used, we compared three different long desensitization protocols for induction of multiple follicular growth in medically assisted conception cycles.
    Summary · context
    In protocol A, 30 patients were injected with buserelin twice a day for 15 days prior to ovarian stimulation until human chorionic gonadotrophin (HCG) administration.
    Summary · context
    In protocol B, 30 patients were injected with a single dose of long acting Triptorelin (3.75 mg) 15 days before the ovarian stimulation onset.
    Summary · context
    In protocol C, 30 patients were injected with the long acting Triptorelin 4 weeks before ovarian stimulation followed by daily administration of 0.1 mg of the same agonist until HCG injection.
  17. 17HumanRandomized controlled trialEfficacy outcome

    In assisted conception, implantation rates per cycle were very similar with triptorelin protocols B and C.

    In plain wordsIn assisted conception, implantation rates were similar between triptorelin protocols B and C.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changeImplantation rate, protocol B versus C
    Study

    n = 60

    Comparator
    Triptorelin protocol C
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    3.75 mg long-acting single dose · injectionAs given in this study (human).

    Source sentences

    Summary
    The ongoing pregnancy rate and the implantation rate per treatment cycle were very similar in the three study groups.
    4 context sentences
    Summary · context
    In a prospective, controlled, randomized study where two different agonists were used, we compared three different long desensitization protocols for induction of multiple follicular growth in medically assisted conception cycles.
    Summary · context
    In protocol A, 30 patients were injected with buserelin twice a day for 15 days prior to ovarian stimulation until human chorionic gonadotrophin (HCG) administration.
    Summary · context
    In protocol B, 30 patients were injected with a single dose of long acting Triptorelin (3.75 mg) 15 days before the ovarian stimulation onset.
    Summary · context
    In protocol C, 30 patients were injected with the long acting Triptorelin 4 weeks before ovarian stimulation followed by daily administration of 0.1 mg of the same agonist until HCG injection.
  18. 18HumanRandomized controlled trialSafety outcome

    In assisted conception, premature luteinization occurred in two patients receiving triptorelin protocol B.

    In plain wordsIn assisted conception, two patients receiving triptorelin protocol B had premature luteinization.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    Not applicablePremature luteinization in protocol B
    Study

    n = 30

    Outcome group
    Adverse events · Reproductive and sexual health
    Studied dose
    3.75 mg long-acting single dose · injectionAs given in this study (human).

    Measurements

    Premature luteinization
    2 patients
    protocol B

    Source sentences

    Summary
    There was no difference in the ovarian response to exogenous gonadotrophin stimulation, except for the presence of premature luteinization in two patients in group B.
    4 context sentences
    Summary · context
    In a prospective, controlled, randomized study where two different agonists were used, we compared three different long desensitization protocols for induction of multiple follicular growth in medically assisted conception cycles.
    Summary · context
    In protocol A, 30 patients were injected with buserelin twice a day for 15 days prior to ovarian stimulation until human chorionic gonadotrophin (HCG) administration.
    Summary · context
    In protocol B, 30 patients were injected with a single dose of long acting Triptorelin (3.75 mg) 15 days before the ovarian stimulation onset.
    Summary · context
    In protocol C, 30 patients were injected with the long acting Triptorelin 4 weeks before ovarian stimulation followed by daily administration of 0.1 mg of the same agonist until HCG injection.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

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