Porcine somatotropic regulation of thymic weight, thymosin beta 4, and insulin-like growth factors in lean and obese swine.

Wise T, Klindt J, Buonomo FC, Yen JT

Journal of animal science1 Sept 1994Cited by 4 (Europe PMC)

PMID8002460DOI10.2527/1994.7292404xPepBankPUB-08002460

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01AnimalEndogenous levelAnimal study (in vivo)Other
In swine given porcine somatotropin, the animals' own thymosin alpha‑1 concentrations were not related to the dose of pST.
In plain wordsIn pigs given growth hormone, the body's own thymosin alpha‑1 levels did not change with the hormone dose.
Peptide
Thymosin alpha-1
Outcome
No significant changeThymosin alpha 1 concentration versus pST dose
Study
pign: not reported in source
Lean and obese gilts and barrows given porcine somatotropin
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
Thymosin alpha 1 concentrations were increased (P < .01) in barrows compared with gilts, but the concentrations were not related to dose of pST.
2 context sentences(design, population, supporting numbers)
Summary · context
Experiment 1 involved genetically lean and obese gilts and barrows injected for 42 d with 0, 2, or 4 mg/d of porcine somatotropin (pST; n = 96).
Summary · context
Experiment 2 involved lean and obese gilts and barrows (n = 48) that were administered implants that released 0, 2, or 4 mg/d of pST for 42 d.
This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0800246001
02AnimalEndogenous levelAnimal study (in vivo)Other
In swine, the animals' own thymosin alpha‑1 concentrations were higher in barrows than in gilts.
In plain wordsIn pigs, the body's own thymosin alpha‑1 levels were higher in barrows than in gilts.
Peptide
Thymosin alpha-1
Outcome
IncreaseThymosin alpha 1 concentration in barrows versus gilts
Study
pign: not reported in source
Lean and obese gilts and barrows given porcine somatotropin
Comparator
Gilts
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
Thymosin alpha 1 concentrations were increased (P < .01) in barrows compared with gilts, but the concentrations were not related to dose of pST.
2 context sentences(design, population, supporting numbers)
Summary · context
Experiment 1 involved genetically lean and obese gilts and barrows injected for 42 d with 0, 2, or 4 mg/d of porcine somatotropin (pST; n = 96).
Summary · context
Experiment 2 involved lean and obese gilts and barrows (n = 48) that were administered implants that released 0, 2, or 4 mg/d of pST for 42 d.
This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0800246002
03AnimalEndogenous levelAnimal study (in vivo)Other
In lean and obese swine, porcine somatotropin raised the body's own thymosin beta‑4 in a dose-dependent manner.
In plain wordsIn pigs, porcine growth hormone raised the body's own thymosin beta‑4 levels as the dose went up.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseThymosin beta 4 with porcine somatotropin dose
Study
pign: not reported in source
Comparator
0 mg/d pST
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
Thymosin beta 4 increased (P < .05) in a pST dose-dependent manner in injected and implanted animals
2 context sentences(design, population, supporting numbers)
Summary · context
Experiment 1 involved genetically lean and obese gilts and barrows injected for 42 d with 0, 2, or 4 mg/d of porcine somatotropin (pST; n = 96).
Summary · context
Experiment 2 involved lean and obese gilts and barrows (n = 48) that were administered implants that released 0, 2, or 4 mg/d of pST for 42 d.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0800246003
04AnimalEndogenous levelAnimal study (in vivo)Other
In swine, thymosin beta‑4 decreased or plateaued in gilts but kept increasing in barrows to the end of the trial.
In plain wordsIn pigs, the body's own thymosin beta‑4 levels fell or leveled off in gilts but kept rising in barrows.
Peptide
Thymosin beta-4 (human)
Outcome
MixedThymosin beta 4 time course in gilts and barrows
Study
pign: not reported in source
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
Concentrations of thymosin beta 4 decreased or reached a plateau in gilts but continued to increase in barrows to the end of the trial.
2 context sentences(design, population, supporting numbers)
Summary · context
Experiment 1 involved genetically lean and obese gilts and barrows injected for 42 d with 0, 2, or 4 mg/d of porcine somatotropin (pST; n = 96).
Summary · context
Experiment 2 involved lean and obese gilts and barrows (n = 48) that were administered implants that released 0, 2, or 4 mg/d of pST for 42 d.
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0800246004

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 4Current
12 Oct 2026, 18:17 UTC
Study data updated · source update from Europe PMC
Version 3
10 Oct 2026, 08:55 UTC
Study results updated
Version 2
9 Oct 2026, 03:03 UTC
Study data updated · source update from Europe PMC
Version 1
9 Oct 2026, 03:02 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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