Effect of dietary carnosine on plasma and tissue antioxidant concentrations and on lipid oxidation in rat skeletal muscle.

Chan WK, Decker EA, Chow CK, Boissonneault GA

Lipids1 Jul 1994Cited by 57 (Europe PMC)

PMID7968266DOI10.1007/bf02578242PepBankPUB-07968266

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study12

8 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Pharmacokinetics
In rats, dietary carnosine did not increase heart carnosine concentrations.
In plain wordsIn rats, dietary carnosine did not increase carnosine levels in the heart.
Peptide
L-carnosine
Outcome
Direction not reportedHeart carnosine concentration
Study
ratn: not reported in source
dietary supplementation
Outcome group
Pharmacokinetics · Pharmacology
Studied dose
0.0875% · dietaryAs given in this study (rat).
Source sentences
Summary
Dietary carnosine supplementation did not increase carnosine concentrations in heart, liver and skeletal muscle.
1 context sentence(design, population, supporting numbers)
Summary · context
Plasma, heart, liver and hind leg muscle was obtained from rats fed basal semipurified diets or basal diets containing carnosine (0.0875%), alpha-tocopheryl acetate (50 ppm), or carnosine (0.0875%) plus alpha-tocopheryl acetate (50 ppm).
Report a problemFND-0796826601
02AnimalAnimal study (in vivo)Pharmacokinetics
In rats, dietary carnosine did not increase liver carnosine concentrations.
In plain wordsIn rats, dietary carnosine did not increase carnosine levels in the liver.
Peptide
L-carnosine
Outcome
Direction not reportedLiver carnosine concentration
Study
ratn: not reported in source
dietary supplementation
Outcome group
Pharmacokinetics · Pharmacology
Studied dose
0.0875% · dietaryAs given in this study (rat).
Source sentences
Summary
Dietary carnosine supplementation did not increase carnosine concentrations in heart, liver and skeletal muscle.
1 context sentence(design, population, supporting numbers)
Summary · context
Plasma, heart, liver and hind leg muscle was obtained from rats fed basal semipurified diets or basal diets containing carnosine (0.0875%), alpha-tocopheryl acetate (50 ppm), or carnosine (0.0875%) plus alpha-tocopheryl acetate (50 ppm).
Report a problemFND-0796826602
03AnimalAnimal study (in vivo)Pharmacokinetics
In rats, dietary carnosine did not increase skeletal muscle carnosine concentrations.
In plain wordsIn rats, dietary carnosine did not increase carnosine levels in skeletal muscle.
Peptide
L-carnosine
Outcome
Direction not reportedMuscle carnosine concentration
Study
ratn: not reported in source
dietary supplementation
Outcome group
Pharmacokinetics · Pharmacology
Studied dose
0.0875% · dietaryAs given in this study (rat).
Source sentences
Summary
Dietary carnosine supplementation did not increase carnosine concentrations in heart, liver and skeletal muscle.
1 context sentence(design, population, supporting numbers)
Summary · context
Plasma, heart, liver and hind leg muscle was obtained from rats fed basal semipurified diets or basal diets containing carnosine (0.0875%), alpha-tocopheryl acetate (50 ppm), or carnosine (0.0875%) plus alpha-tocopheryl acetate (50 ppm).
Report a problemFND-0796826603
04AnimalAnimal study (in vivo)Pharmacokinetics
In rats, carnosine plus alpha-tocopherol increased liver carnosine 1.56-fold compared with the diet lacking carnosine.
In plain wordsIn rats, adding carnosine to alpha-tocopherol increased liver carnosine compared with the diet without carnosine.
Peptide
L-carnosine
Outcome
IncreaseLiver carnosine concentration
Study
ratn: not reported in source
dietary supplementation
Comparator
diet lacking carnosine
Outcome group
Pharmacokinetics · Pharmacology
Studied dose
0.0875% · dietaryAs given in this study (rat).
Source sentences
Summary
Dietary supplementation with both carnosine and alpha-tocopherol increased carnosine concentrations in liver 1.56, 1.51- and 1.51-fold as compared with diets lacking carnosine, alpha-tocopherol or both carnosine and alpha-tocopherol, respectively.
1 context sentence(design, population, supporting numbers)
Summary · context
Plasma, heart, liver and hind leg muscle was obtained from rats fed basal semipurified diets or basal diets containing carnosine (0.0875%), alpha-tocopheryl acetate (50 ppm), or carnosine (0.0875%) plus alpha-tocopheryl acetate (50 ppm).
Report a problemFND-0796826604
05AnimalAnimal study (in vivo)Mechanism
In rats, carnosine plus alpha-tocopherol increased heart alpha-tocopherol compared with alpha-tocopherol alone.
In plain wordsIn rats, adding carnosine increased heart alpha-tocopherol compared with alpha-tocopherol alone.
Peptide
L-carnosine
Outcome
IncreaseHeart alpha-tocopherol concentration
Study
ratn: not reported in source
dietary supplementation
Comparator
alpha-tocopherol alone
Outcome group
Oxidative stress · Cardiovascular
Studied dose
0.0875% · dietaryAs given in this study (rat).
Measurements
Heart alpha-tocopherol increase
1 to 38 fold
versus alpha-tocopherol alone
Source sentences
Summary
Dietary supplementation with both carnosine and alpha-tocopherol also increased alpha-tocopherol concentrations in heart and liver 1-38-fold and 1.68-fold, respectively, as compared to supplementation with alpha-tocopherol alone.
1 context sentence(design, population, supporting numbers)
Summary · context
Plasma, heart, liver and hind leg muscle was obtained from rats fed basal semipurified diets or basal diets containing carnosine (0.0875%), alpha-tocopheryl acetate (50 ppm), or carnosine (0.0875%) plus alpha-tocopheryl acetate (50 ppm).
Report a problemFND-0796826607
06AnimalAnimal study (in vivo)Mechanism
In rats, carnosine plus alpha-tocopherol increased liver alpha-tocopherol 1.68-fold compared with alpha-tocopherol alone.
In plain wordsIn rats, adding carnosine increased liver alpha-tocopherol compared with alpha-tocopherol alone.
Peptide
L-carnosine
Outcome
IncreaseLiver alpha-tocopherol concentration
Study
ratn: not reported in source
dietary supplementation
Comparator
alpha-tocopherol alone
Outcome group
Oxidative stress · Liver
Studied dose
0.0875% · dietaryAs given in this study (rat).
Source sentences
Summary
Dietary supplementation with both carnosine and alpha-tocopherol also increased alpha-tocopherol concentrations in heart and liver 1-38-fold and 1.68-fold, respectively, as compared to supplementation with alpha-tocopherol alone.
1 context sentence(design, population, supporting numbers)
Summary · context
Plasma, heart, liver and hind leg muscle was obtained from rats fed basal semipurified diets or basal diets containing carnosine (0.0875%), alpha-tocopheryl acetate (50 ppm), or carnosine (0.0875%) plus alpha-tocopheryl acetate (50 ppm).
Report a problemFND-0796826608
07AnimalAnimal study (in vivo)Mechanism
In rats, dietary carnosine decreased TBARS formation in skeletal muscle homogenates.
In plain wordsIn rats, dietary carnosine reduced oxidation products in muscle homogenates.
Peptide
L-carnosine
Outcome
DecreaseMuscle homogenate TBARS formation
Study
ratn: not reported in source
dietary supplementation
Outcome group
Oxidative stress · Musculoskeletal
Studied dose
0.0875% · dietaryAs given in this study (rat).
Source sentences
Summary
Dietary supplementation with carnosine, alpha-tocopherol or both carnosine and alpha-tocopherol was effective in decreasing the formation of TBARS in rat skeletal muscle homogenate, with dietary alpha-tocopherol and alpha-tocopherol plus carnosine being more effective than dietary carnosine alone.
1 context sentence(design, population, supporting numbers)
Summary · context
Plasma, heart, liver and hind leg muscle was obtained from rats fed basal semipurified diets or basal diets containing carnosine (0.0875%), alpha-tocopheryl acetate (50 ppm), or carnosine (0.0875%) plus alpha-tocopheryl acetate (50 ppm).
Report a problemFND-0796826609
08AnimalAnimal study (in vivo)Mechanism
In rats, dietary carnosine decreased muscle homogenate TBARS formation less effectively than alpha-tocopherol alone.
In plain wordsIn rats, carnosine reduced muscle oxidation products less effectively than alpha-tocopherol alone.
Peptide
L-carnosine
Outcome
IncreaseMuscle homogenate TBARS formation
Study
ratn: not reported in source
dietary supplementation
Comparator
alpha-tocopherol alone
Outcome group
Oxidative stress · Musculoskeletal
Studied dose
0.0875% · dietaryAs given in this study (rat).
Source sentences
Summary
Dietary supplementation with carnosine, alpha-tocopherol or both carnosine and alpha-tocopherol was effective in decreasing the formation of TBARS in rat skeletal muscle homogenate, with dietary alpha-tocopherol and alpha-tocopherol plus carnosine being more effective than dietary carnosine alone.
1 context sentence(design, population, supporting numbers)
Summary · context
Plasma, heart, liver and hind leg muscle was obtained from rats fed basal semipurified diets or basal diets containing carnosine (0.0875%), alpha-tocopheryl acetate (50 ppm), or carnosine (0.0875%) plus alpha-tocopheryl acetate (50 ppm).
Report a problemFND-0796826612

Studies that did not test the peptide alone4

In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking L-carnosine.

09AnimalNot a test of L-carnosine aloneAnimal study (in vivo)Pharmacokinetics
In rats, carnosine plus alpha-tocopherol increased liver carnosine 1.51-fold compared with the diet lacking alpha-tocopherol.
In plain wordsIn rats, the combination increased liver carnosine compared with the diet without alpha-tocopherol.
Peptide
L-carnosine
Outcome
IncreaseLiver carnosine concentration
Study
ratn: not reported in source
dietary supplementation
Comparator
diet lacking alpha-tocopherol
Outcome group
Pharmacokinetics · Pharmacology
Source sentences
Summary
Dietary supplementation with both carnosine and alpha-tocopherol increased carnosine concentrations in liver 1.56, 1.51- and 1.51-fold as compared with diets lacking carnosine, alpha-tocopherol or both carnosine and alpha-tocopherol, respectively.
1 context sentence(design, population, supporting numbers)
Summary · context
Plasma, heart, liver and hind leg muscle was obtained from rats fed basal semipurified diets or basal diets containing carnosine (0.0875%), alpha-tocopheryl acetate (50 ppm), or carnosine (0.0875%) plus alpha-tocopheryl acetate (50 ppm).
In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.
Report a problemFND-0796826605
10AnimalNot a test of L-carnosine aloneAnimal study (in vivo)Pharmacokinetics
In rats, carnosine plus alpha-tocopherol increased liver carnosine 1.51-fold compared with the diet lacking both supplements.
In plain wordsIn rats, the combination increased liver carnosine compared with the diet without either supplement.
Peptide
L-carnosine
Outcome
IncreaseLiver carnosine concentration
Study
ratn: not reported in source
dietary supplementation
Comparator
diet lacking both supplements
Outcome group
Pharmacokinetics · Pharmacology
Source sentences
Summary
Dietary supplementation with both carnosine and alpha-tocopherol increased carnosine concentrations in liver 1.56, 1.51- and 1.51-fold as compared with diets lacking carnosine, alpha-tocopherol or both carnosine and alpha-tocopherol, respectively.
1 context sentence(design, population, supporting numbers)
Summary · context
Plasma, heart, liver and hind leg muscle was obtained from rats fed basal semipurified diets or basal diets containing carnosine (0.0875%), alpha-tocopheryl acetate (50 ppm), or carnosine (0.0875%) plus alpha-tocopheryl acetate (50 ppm).
In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.
Report a problemFND-0796826606
11AnimalNot a test of L-carnosine aloneAnimal study (in vivo)Mechanism
In rats, dietary carnosine plus alpha-tocopherol decreased TBARS formation in skeletal muscle homogenates.
In plain wordsIn rats, the carnosine combination reduced oxidation products in muscle homogenates.
Peptide
L-carnosine
Outcome
DecreaseMuscle homogenate TBARS formation
Study
ratn: not reported in source
dietary supplementation
Outcome group
Oxidative stress · Musculoskeletal
Source sentences
Summary
Dietary supplementation with carnosine, alpha-tocopherol or both carnosine and alpha-tocopherol was effective in decreasing the formation of TBARS in rat skeletal muscle homogenate, with dietary alpha-tocopherol and alpha-tocopherol plus carnosine being more effective than dietary carnosine alone.
1 context sentence(design, population, supporting numbers)
Summary · context
Plasma, heart, liver and hind leg muscle was obtained from rats fed basal semipurified diets or basal diets containing carnosine (0.0875%), alpha-tocopheryl acetate (50 ppm), or carnosine (0.0875%) plus alpha-tocopheryl acetate (50 ppm).
In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.
Report a problemFND-0796826610
12AnimalNot a test of L-carnosine aloneAnimal study (in vivo)Mechanism
In rats, carnosine plus alpha-tocopherol decreased muscle homogenate TBARS formation more than carnosine alone.
In plain wordsIn rats, the combination reduced muscle oxidation products more than carnosine alone.
Peptide
L-carnosine
Outcome
DecreaseMuscle homogenate TBARS formation
Study
ratn: not reported in source
dietary supplementation
Comparator
carnosine alone
Outcome group
Oxidative stress · Musculoskeletal
Source sentences
Summary
Dietary supplementation with carnosine, alpha-tocopherol or both carnosine and alpha-tocopherol was effective in decreasing the formation of TBARS in rat skeletal muscle homogenate, with dietary alpha-tocopherol and alpha-tocopherol plus carnosine being more effective than dietary carnosine alone.
1 context sentence(design, population, supporting numbers)
Summary · context
Plasma, heart, liver and hind leg muscle was obtained from rats fed basal semipurified diets or basal diets containing carnosine (0.0875%), alpha-tocopheryl acetate (50 ppm), or carnosine (0.0875%) plus alpha-tocopheryl acetate (50 ppm).
In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.
Report a problemFND-0796826611

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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MeSH terms

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