Arginine and growth hormone-releasing hormone restore the blunted growth hormone-releasing activity of hexarelin in elderly subjects.

Arvat E, Gianotti L, Grottoli S, Imbimbo BP, Lenaerts V, Deghenghi R, Camanni F, Ghigo E

The Journal of clinical endocrinology and metabolism1 Nov 1994Cited by 50 (Europe PMC)

PMID7962341DOI10.1210/jcem.79.5.7962341PepBankPUB-07962341

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

4 results from studies that gave the peptide. 4 results from people.

01HumanRandomized controlled trialEfficacy outcome
In normal males, the GH response to hexarelin was lower in elderly than in young subjects.
In plain wordsIn healthy men, hexarelin raised growth hormone less in older men than in younger men.
Peptide
Hexarelin
Outcome
DecreaseGH response to hexarelin, young versus elderly (first group)
Study
n = 15
Comparator
Young subjects
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
2 micrograms/kg · intravenousAs given in this study (human).
Measurements
GH AUC0-120
4849 micrograms.min/L
young
GH AUC0-120
2112 micrograms.min/L
elderly
Source sentences
Summary
In the first group the GH response to hexarelin was greater in young compared to elderly subjects (area under the curve from 0-120 = 4849 +/- 601 vs. 2112 +/- 683 micrograms.min/L; P < 0.001).
2 context sentences(design, population, supporting numbers)
Summary · context
The first group (7 young and 8 elderly subjects) received the following as single iv injections during 3 different treatment sessions: hexarelin (2 micrograms/kg), GHRH (2 micrograms/kg), or hexarelin (2 micrograms/kg) plus GHRH (2 micrograms/kg).
Summary · context
Thirteen young (24- to 30-yr-old) and 16 elderly (65- to 84-yr-old) normal males were divided into 2 groups.
Report a problemFND-0796234101
02HumanRandomized controlled trialEfficacy outcome
In the second group, the GH response to hexarelin was again lower in elderly than in young subjects.
In plain wordsIn a second group of healthy men, hexarelin again raised growth hormone less in older men than in younger men.
Peptide
Hexarelin
Outcome
DecreaseGH response to hexarelin, young versus elderly (second group)
Study
n = 14
Comparator
Young subjects
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
2 micrograms/kg · intravenousAs given in this study (human).
Measurements
GH response
4819 micrograms/min.L
young
GH response
1649 micrograms/min.L
elderly
Source sentences
Summary
In the second group, the GH response induced by hexarelin was also higher in young subjects than in elderly subjects (4819 +/- 668 vs. 1649 +/- 459 micrograms/min.L; P < 0.001).
2 context sentences(design, population, supporting numbers)
Summary · context
The second group (6 young and 8 elderly subjects) was administered single iv injections of hexarelin (2 micrograms/kg) or hexarelin (2 micrograms/kg) plus arginine (0.5 g/kg) during 2 different treatment sessions.
Summary · context
Thirteen young (24- to 30-yr-old) and 16 elderly (65- to 84-yr-old) normal males were divided into 2 groups.
Report a problemFND-0796234102
03HumanRandomized controlled trialEfficacy outcome
In elderly males, hexarelin elicited a higher GH response than GHRH.
In plain wordsIn older men, hexarelin raised growth hormone more than GHRH did.
Peptide
Hexarelin
Outcome
IncreaseGH response to hexarelin versus GHRH in elderly subjects
Study
n = 8
Comparator
GHRH 2 micrograms/kg
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
2 micrograms/kg · intravenousAs given in this study (human).
Measurements
GH response to GHRH
563 micrograms/min.L
elderly
Source sentences
Summary
GHRH elicited a lower GH response than that induced by hexarelin in both young (1455 +/- 102 micrograms/h.L; P < 0.02) and elderly subjects (563 +/- 87 micrograms/min.L; P < 0.02).
2 context sentences(design, population, supporting numbers)
Summary · context
The first group (7 young and 8 elderly subjects) received the following as single iv injections during 3 different treatment sessions: hexarelin (2 micrograms/kg), GHRH (2 micrograms/kg), or hexarelin (2 micrograms/kg) plus GHRH (2 micrograms/kg).
Summary · context
Thirteen young (24- to 30-yr-old) and 16 elderly (65- to 84-yr-old) normal males were divided into 2 groups.
Report a problemFND-0796234104
04HumanRandomized controlled trialEfficacy outcome
In young males, hexarelin elicited a higher GH response than GHRH.
In plain wordsIn young men, hexarelin raised growth hormone more than GHRH did.
Peptide
Hexarelin
Outcome
IncreaseGH response to hexarelin versus GHRH in young subjects
Study
n = 7
Comparator
GHRH 2 micrograms/kg
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
2 micrograms/kg · intravenousAs given in this study (human).
Measurements
GH response to GHRH
1455 micrograms/h.L
young
Source sentences
Summary
GHRH elicited a lower GH response than that induced by hexarelin in both young (1455 +/- 102 micrograms/h.L; P < 0.02) and elderly subjects (563 +/- 87 micrograms/min.L; P < 0.02).
2 context sentences(design, population, supporting numbers)
Summary · context
The first group (7 young and 8 elderly subjects) received the following as single iv injections during 3 different treatment sessions: hexarelin (2 micrograms/kg), GHRH (2 micrograms/kg), or hexarelin (2 micrograms/kg) plus GHRH (2 micrograms/kg).
Summary · context
Thirteen young (24- to 30-yr-old) and 16 elderly (65- to 84-yr-old) normal males were divided into 2 groups.
Report a problemFND-0796234103

Studies that did not test the peptide alone5

In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Hexarelin.

05HumanNot a test of Hexarelin aloneRandomized controlled trialEfficacy outcome
The GH response to combined hexarelin and GHRH was significantly higher in young than in elderly subjects.
In plain wordsHexarelin plus GHRH raised growth hormone more in young men than in older men.
Peptide
Hexarelin
Outcome
DecreaseGH response to hexarelin plus GHRH, elderly versus young
Study
n = 15
Comparator
Young subjects
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
the GH response to the combined administration of hexarelin and GHRH was significantly higher in young subjects compared to elderly subjects.
2 context sentences(design, population, supporting numbers)
Summary · context
The first group (7 young and 8 elderly subjects) received the following as single iv injections during 3 different treatment sessions: hexarelin (2 micrograms/kg), GHRH (2 micrograms/kg), or hexarelin (2 micrograms/kg) plus GHRH (2 micrograms/kg).
Summary · context
Thirteen young (24- to 30-yr-old) and 16 elderly (65- to 84-yr-old) normal males were divided into 2 groups.
In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.
Report a problemFND-0796234107
06HumanNot a test of Hexarelin aloneRandomized controlled trialEfficacy outcome
In elderly males, adding GHRH to hexarelin potentiated the GH response.
In plain wordsIn older men, giving GHRH together with hexarelin raised growth hormone more.
Peptide
Hexarelin
Outcome
IncreaseGH response to hexarelin plus GHRH in elderly subjects
Study
n = 8
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Measurements
GH response
3895 micrograms/min.L
hexarelin plus GHRH, elderly
Source sentences
Summary
GHRH potentiated the somatotrope response to hexarelin in both young (7725 +/- 503 micrograms/min.L; P < 0.02) and elderly subjects (3895 +/- 612 micrograms/min.L; P < 0.02), but to a lesser extent in the latter (P < 0.001).
2 context sentences(design, population, supporting numbers)
Summary · context
The first group (7 young and 8 elderly subjects) received the following as single iv injections during 3 different treatment sessions: hexarelin (2 micrograms/kg), GHRH (2 micrograms/kg), or hexarelin (2 micrograms/kg) plus GHRH (2 micrograms/kg).
Summary · context
Thirteen young (24- to 30-yr-old) and 16 elderly (65- to 84-yr-old) normal males were divided into 2 groups.
In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.
Report a problemFND-0796234106
07HumanNot a test of Hexarelin aloneRandomized controlled trialEfficacy outcome
In elderly males, arginine potentiated the GH response to hexarelin.
In plain wordsIn older men, giving arginine together with hexarelin raised growth hormone more than hexarelin alone.
Peptide
Hexarelin
Outcome
IncreaseGH response to hexarelin plus arginine in elderly subjects
Study
n = 8
Comparator
Hexarelin alone
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Measurements
GH response
4139 micrograms/min.L
hexarelin plus arginine, elderly
Source sentences
Summary
The GH response to hexarelin was potentiated by arginine in elderly (4139 +/- 1057 micrograms/min. L; P < 0.001), but not in young subjects (4743 +/- 774 micrograms/min.L).
2 context sentences(design, population, supporting numbers)
Summary · context
The second group (6 young and 8 elderly subjects) was administered single iv injections of hexarelin (2 micrograms/kg) or hexarelin (2 micrograms/kg) plus arginine (0.5 g/kg) during 2 different treatment sessions.
Summary · context
Thirteen young (24- to 30-yr-old) and 16 elderly (65- to 84-yr-old) normal males were divided into 2 groups.
In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.
Report a problemFND-0796234108
08HumanNot a test of Hexarelin aloneRandomized controlled trialEfficacy outcome
In young males, adding GHRH to hexarelin potentiated the GH response.
In plain wordsIn young men, giving GHRH together with hexarelin raised growth hormone more.
Peptide
Hexarelin
Outcome
IncreaseGH response to hexarelin plus GHRH in young subjects
Study
n = 7
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Measurements
GH response
7725 micrograms/min.L
hexarelin plus GHRH, young
Source sentences
Summary
GHRH potentiated the somatotrope response to hexarelin in both young (7725 +/- 503 micrograms/min.L; P < 0.02) and elderly subjects (3895 +/- 612 micrograms/min.L; P < 0.02), but to a lesser extent in the latter (P < 0.001).
2 context sentences(design, population, supporting numbers)
Summary · context
The first group (7 young and 8 elderly subjects) received the following as single iv injections during 3 different treatment sessions: hexarelin (2 micrograms/kg), GHRH (2 micrograms/kg), or hexarelin (2 micrograms/kg) plus GHRH (2 micrograms/kg).
Summary · context
Thirteen young (24- to 30-yr-old) and 16 elderly (65- to 84-yr-old) normal males were divided into 2 groups.
In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.
Report a problemFND-0796234105
09HumanNot a test of Hexarelin aloneRandomized controlled trialEfficacy outcome
In young males, arginine did not potentiate the GH response to hexarelin.
In plain wordsIn young men, giving arginine together with hexarelin did not raise growth hormone more than hexarelin alone.
Peptide
Hexarelin
Outcome
No significant changeGH response to hexarelin plus arginine in young subjects
Study
n = 6
Comparator
Hexarelin alone
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Measurements
GH response
4743 micrograms/min.L
hexarelin plus arginine, young
Source sentences
Summary
The GH response to hexarelin was potentiated by arginine in elderly (4139 +/- 1057 micrograms/min. L; P < 0.001), but not in young subjects (4743 +/- 774 micrograms/min.L).
2 context sentences(design, population, supporting numbers)
Summary · context
The second group (6 young and 8 elderly subjects) was administered single iv injections of hexarelin (2 micrograms/kg) or hexarelin (2 micrograms/kg) plus arginine (0.5 g/kg) during 2 different treatment sessions.
Summary · context
Thirteen young (24- to 30-yr-old) and 16 elderly (65- to 84-yr-old) normal males were divided into 2 groups.
In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.
Report a problemFND-0796234109

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

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