In male rats, VIP injected into the paraventricular nucleus increased plasma ACTH in a dose-dependent manner, to 167% of time-matched controls at the highest dose.
In plain wordsIn rats, VIP injected into a brain region raised blood ACTH, a stress hormone, in a dose-dependent way.
- Outcome
- IncreasePlasma ACTH
- Study
ratn: not reported in source
fasted, freely-moving male rats with a PVN cannula- Comparator
- Saline
- Outcome group
- Stress hormones · Endocrine and hormones
- Studied dose
- 0.15-3.0 nmol/rat · injection into the PVNAs given in this study (rat).
Measurements
- Plasma ACTH
- 167 % of time-matched controls
- highest VIP dose
Source sentences
PVN administration of VIP increased the plasma ACTH and CORT levels in a dose-dependent manner and the maximal effect was obtained at 15 min after administration.
2 context sentences(design, population, supporting numbers)
At the highest dose tested, VIP increased ACTH and CORT to 167% and 342% of time-matched controls
Male rats, chronically implanted with a hypothalamic paraventricular nucleus (PVN) cannula, were injected with VIP doses (0.15-3.0 nmol/rat) of VIP or saline (control).