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Study · In vitro (cells) · mouse · 1994

2 results

The human melanocyte stimulating hormone receptor has evolved to become "super-sensitive" to melanocortin peptides.

Mountjoy KG

Molecular and cellular endocrinology1 Jun 1994Cited by 61 (Europe PMC)

PMID7926261 (opens in a new tab)DOI10.1016/0303-7207(94)90113-9 (opens in a new tab)PepBankPUB-07926261
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    At the cloned human MC1 receptor, NDP-MSH had an EC50 of 1-2 pM, as at the mouse receptor.

    In plain wordsIn lab tests on the cloned human MC1 receptor, NDP-MSH was active at very low concentrations (1-2 pM).

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    Not applicableNDP-MSH potency at human MC1-R (EC50)
    Study

    humann: not reported in source

    cloned human MC1-R
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Measurements

    EC50
    1 to 2 pM
    human MC1-R

    Source sentences

    Summary
    The human and mouse MC1-Rs are equally sensitive (EC50 = 1-2 pM) to the super potent analogue of alpha-MSH, NDP-MSH.
    1 context sentence
    Summary · context
    The pharmacological characterisation of a cloned human MC1-R (hMC1-R) is reported here, and directly compared with that of a cloned mouse MC1-R (mMC1-R).
  2. 02LabIn vitro (cells)Activity measurement

    At the cloned mouse MC1 receptor, NDP-MSH had an EC50 of 1-2 pM, as at the human receptor.

    In plain wordsIn lab tests on the cloned mouse MC1 receptor, NDP-MSH was active at very low concentrations (1-2 pM).

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    Not applicableNDP-MSH potency at mouse MC1-R (EC50)
    Study

    mousen: not reported in source

    cloned mouse MC1-R
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Measurements

    EC50
    1 to 2 pM
    mouse MC1-R

    Source sentences

    Summary
    The human and mouse MC1-Rs are equally sensitive (EC50 = 1-2 pM) to the super potent analogue of alpha-MSH, NDP-MSH.
    1 context sentence
    Summary · context
    The pharmacological characterisation of a cloned human MC1-R (hMC1-R) is reported here, and directly compared with that of a cloned mouse MC1-R (mMC1-R).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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