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Study · Animal study (in vivo) · sheep · 1994

3 results

Growth hormone (GH)-releasing hormone secretion is stimulated by a new GH-releasing hexapeptide in sheep.

Guillaume V, Magnan E, Cataldi M, Dutour A, Sauze N, Renard M, Razafindraibe H, Conte-Devolx B, Deghenghi R, Lenaerts V

Endocrinology1 Sept 1994Cited by 87 (Europe PMC)

PMID7915227 (opens in a new tab)DOI10.1210/endo.135.3.7915227 (opens in a new tab)PepBankPUB-07915227
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In conscious rams, intravenous hexarelin increased jugular GH levels at 15 min.

    In plain wordsIn rams, hexarelin raised GH levels in the blood 15 minutes after injection.

    Peptide
    Hexarelin
    Outcome
    IncreaseJugular GH level 15 min after hexarelin
    Study

    sheepn = 6

    Conscious rams with hypophysial portal blood sampling
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1 mg · intravenousAs given in this study (sheep).

    Measurements

    Jugular GH
    9.1 ng/ml
    after hexarelin
    Jugular GH
    3.9 ng/ml
    comparison value

    Source sentences

    Summary
    An increase in jugular GH levels was observed 15 min after hexarelin injection (9.1 +/- 1.8 vs. 3.9 +/- 0.8 ng/ml; P < 0.05).
    2 context sentences
    Summary · context
    The acute effect of a new GH-releasing peptide, hexarelin (1 mg, iv), on GH secretion and the mechanisms involved in its changes were investigated in conscious sheep.
    Summary · context
    Peripheral GH levels and GH-releasing hormone (GHRH) and somatostatin concentrations in hypophysial portal blood were measured in six rams.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In conscious rams, hexarelin stimulated GHRH release into hypophysial portal blood.

    In plain wordsIn rams, hexarelin increased the release of GHRH into the blood vessels around the pituitary gland.

    Peptide
    Hexarelin
    Outcome
    IncreaseGHRH release into hypophysial portal blood
    Study

    sheepn = 6

    Conscious rams with hypophysial portal blood sampling
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1 mg · intravenousAs given in this study (sheep).

    Measurements

    Portal GHRH
    145.4 pg/ml
    after hexarelin
    Portal GHRH
    59.2 pg/ml
    comparison value

    Source sentences

    Summary
    This was associated with a stimulation of GHRH release into hypophysial portal blood (145.4 +/- 19.9 vs. 59.2 +/- 10.8 pg/ml; P < 0.01)
    2 context sentences
    Summary · context
    The acute effect of a new GH-releasing peptide, hexarelin (1 mg, iv), on GH secretion and the mechanisms involved in its changes were investigated in conscious sheep.
    Summary · context
    Peripheral GH levels and GH-releasing hormone (GHRH) and somatostatin concentrations in hypophysial portal blood were measured in six rams.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In conscious rams, hexarelin did not change somatostatin secretion into hypophysial portal blood.

    In plain wordsIn rams, hexarelin did not change the release of somatostatin.

    Peptide
    Hexarelin
    Outcome
    No significant changeSomatostatin secretion
    Study

    sheepn = 6

    Conscious rams with hypophysial portal blood sampling
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1 mg · intravenousAs given in this study (sheep).

    Source sentences

    Summary
    without a change in somatostatin secretion.
    2 context sentences
    Summary · context
    The acute effect of a new GH-releasing peptide, hexarelin (1 mg, iv), on GH secretion and the mechanisms involved in its changes were investigated in conscious sheep.
    Summary · context
    Peripheral GH levels and GH-releasing hormone (GHRH) and somatostatin concentrations in hypophysial portal blood were measured in six rams.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

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