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Study · Animal study (in vivo) · rat · 1994

4 results

The beneficial effect of BPC 157, a 15 amino acid peptide BPC fragment, on gastric and duodenal lesions induced by restraint stress, cysteamine and 96% ethanol in rats. A comparative study with H2 receptor antagonists, dopamine promotors and gut peptides.

Sikiric P, Seiwerth S, Grabarevic Z, Petek M, Rucman R, Turkovic B, Rotkvic I, Jagic V, Duvnjak M, Mise S

Life sciences1 Jan 1994Cited by 73 (Europe PMC)

PMID7904712 (opens in a new tab)DOI10.1016/0024-3205(94)00796-9 (opens in a new tab)PepBankPUB-07904712
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with restraint stress ulcers, BPC‑157 regimens were consistently effective, while bromocriptine, amantadine, famotidine, cimetidine and somatostatin were ineffective.

    In plain wordsIn rats with stress-induced stomach and duodenal ulcers, BPC‑157 protected consistently, while several reference drugs did not.

    Peptide
    BPC-157
    Outcome
    DecreaseRestraint stress ulcer (48 h)
    Study

    ratn: not reported in source

    48-h restraint stress ulcer
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated · intraperitoneal or intragastricAs given in this study (rat).

    Source sentences

    Summary
    Only BPC 157 regimens were consistently effective in all of the tested models.
    2 context sentences
    Summary · context
    On the other hand, bromocriptine, amantadine, famotidine, cimetidine and somatostatin were ineffective (restraint stress).
    Summary · context
    BPC 157 (i.p./i.g.) was investigated in rats in comparison with several reference standards in three experimental ulcer models (48 h-restraint stress, subcutaneous cysteamine, intragastrical 96% ethanol ulcer tests) (pre-/co-/post-treatment).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with cysteamine-induced ulcers, BPC‑157 regimens were consistently effective.

    In plain wordsIn rats with cysteamine-induced ulcers, BPC‑157 protected consistently.

    Peptide
    BPC-157
    Outcome
    DecreaseSubcutaneous cysteamine ulcer
    Study

    ratn: not reported in source

    Cysteamine ulcer
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated · intraperitoneal or intragastricAs given in this study (rat).

    Source sentences

    Summary
    Only BPC 157 regimens were consistently effective in all of the tested models.
    1 context sentence
    Summary · context
    BPC 157 (i.p./i.g.) was investigated in rats in comparison with several reference standards in three experimental ulcer models (48 h-restraint stress, subcutaneous cysteamine, intragastrical 96% ethanol ulcer tests) (pre-/co-/post-treatment).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with 96% ethanol-induced ulcers, BPC‑157 regimens were consistently effective.

    In plain wordsIn rats with alcohol-induced ulcers, BPC‑157 protected consistently.

    Peptide
    BPC-157
    Outcome
    DecreaseIntragastric 96% ethanol ulcer
    Study

    ratn: not reported in source

    96% ethanol ulcer
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated · intraperitoneal or intragastricAs given in this study (rat).

    Source sentences

    Summary
    Only BPC 157 regimens were consistently effective in all of the tested models.
    1 context sentence
    Summary · context
    BPC 157 (i.p./i.g.) was investigated in rats in comparison with several reference standards in three experimental ulcer models (48 h-restraint stress, subcutaneous cysteamine, intragastrical 96% ethanol ulcer tests) (pre-/co-/post-treatment).
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats, Monastral blue studies suggest that the beneficial effect of BPC‑157 appears related to strong endothelial protection.

    In plain wordsIn rats, tests suggest that BPC‑157 protects the lining of blood vessels, which may explain its benefit.

    Peptide
    BPC-157
    Outcome
    Not applicableEndothelial protection (Monastral blue studies)
    Study

    ratn: not reported in source

    Ulcer models, Monastral blue studies
    Outcome group
    Receptor activity and mechanism · Gastrointestinal
    Studied dose
    Dose not stated · intraperitoneal or intragastricAs given in this study (rat).

    Source sentences

    Summary
    Based on Monastral blue studies BPC 157 beneficial effect appears to be related to a strong endothelial protection.
    1 context sentence
    Summary · context
    BPC 157 (i.p./i.g.) was investigated in rats in comparison with several reference standards in three experimental ulcer models (48 h-restraint stress, subcutaneous cysteamine, intragastrical 96% ethanol ulcer tests) (pre-/co-/post-treatment).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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