Hepatoprotective effect of BPC 157, a 15-amino acid peptide, on liver lesions induced by either restraint stress or bile duct and hepatic artery ligation or CCl4 administration. A comparative study with dopamine agonists and somatostatin.

Sikiric P, Seiwerth S, Grabarevic Z, Rucman R, Petek M, Rotkvic I, Turkovic B, Jagic V, Mildner B, Duvnjak M

Life sciences1 Jan 1993Cited by 51 (Europe PMC)

PMID7901724DOI10.1016/0024-3205(93)90589-uPepBankPUB-07901724

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with bile duct and hepatic artery ligation, BPC‑157 significantly prevented liver necrosis or fatty changes.
In plain wordsIn rats with liver injury from ligation, BPC‑157 prevented liver cell death and fatty changes.
Peptide
BPC-157
Outcome
DecreaseLiver necrosis or fatty changes after bile duct and hepatic artery ligation
Study
ratn: not reported in source
24-h bile duct plus hepatic artery ligation
Outcome group
Liver fat and liver function · Liver
Studied dose
Dose not stated · intragastric or intraperitonealAs given in this study (rat).
Source sentences
Summary
BPC 157 administered either intragastrically or intraperitoneally, significantly prevented the development of liver necrosis or fatty changes in rats subjected to 24 h bile duct + hepatic artery ligation, 48 h-restraint stress, CCl4 treatment (1 ml/kg i.p., sacrifice 48 h thereafter).
1 context sentence(design, population, supporting numbers)
Summary · context
The hepatoprotective effects of a newly synthesized 15 amino acid fragment code named BPC 157 was evaluated in comparison with the reference standards (bromocriptine, amantadine and somatostatin) in various experimental models of liver injury in rats: 24 h-bile duct+hepatic artery ligation 48 h-rest…
Report a problemFND-0790172401
02AnimalAnimal study (in vivo)Efficacy outcome
In rats under restraint stress, BPC‑157 significantly prevented liver necrosis or fatty changes.
In plain wordsIn rats with stress-induced liver injury, BPC‑157 prevented liver cell death and fatty changes.
Peptide
BPC-157
Outcome
DecreaseLiver necrosis or fatty changes after restraint stress
Study
ratn: not reported in source
48-h restraint stress
Outcome group
Liver fat and liver function · Liver
Studied dose
Dose not stated · intragastric or intraperitonealAs given in this study (rat).
Source sentences
Summary
BPC 157 administered either intragastrically or intraperitoneally, significantly prevented the development of liver necrosis or fatty changes in rats subjected to 24 h bile duct + hepatic artery ligation, 48 h-restraint stress, CCl4 treatment (1 ml/kg i.p., sacrifice 48 h thereafter).
1 context sentence(design, population, supporting numbers)
Summary · context
The hepatoprotective effects of a newly synthesized 15 amino acid fragment code named BPC 157 was evaluated in comparison with the reference standards (bromocriptine, amantadine and somatostatin) in various experimental models of liver injury in rats: 24 h-bile duct+hepatic artery ligation 48 h-rest…
Report a problemFND-0790172402
03AnimalAnimal study (in vivo)Efficacy outcome
In rats given CCl4, BPC‑157 significantly prevented liver necrosis or fatty changes.
In plain wordsIn rats with CCl4-induced liver injury, BPC‑157 prevented liver cell death and fatty changes.
Peptide
BPC-157
Outcome
DecreaseLiver necrosis or fatty changes after CCl4
Study
ratn: not reported in source
CCl4 administration
Outcome group
Liver fat and liver function · Liver
Studied dose
Dose not stated · intragastric or intraperitonealAs given in this study (rat).
Source sentences
Summary
BPC 157 administered either intragastrically or intraperitoneally, significantly prevented the development of liver necrosis or fatty changes in rats subjected to 24 h bile duct + hepatic artery ligation, 48 h-restraint stress, CCl4 treatment (1 ml/kg i.p., sacrifice 48 h thereafter).
1 context sentence(design, population, supporting numbers)
Summary · context
The hepatoprotective effects of a newly synthesized 15 amino acid fragment code named BPC 157 was evaluated in comparison with the reference standards (bromocriptine, amantadine and somatostatin) in various experimental models of liver injury in rats: 24 h-bile duct+hepatic artery ligation 48 h-rest…
Report a problemFND-0790172403
04AnimalAnimal study (in vivo)Efficacy outcome
In rats with experimental liver injury, serum bilirubin results fully correlated with the macroscopic and microscopic findings.
In plain wordsIn rats with liver injury, blood bilirubin results matched the tissue findings.
Peptide
BPC-157
Outcome
Direction not reportedSerum bilirubin
Study
ratn: not reported in source
Liver injury models
Outcome group
Liver fat and liver function · Liver
Studied dose
Dose not stated · intragastric or intraperitonealAs given in this study (rat).
Source sentences
Summary
Noteworthy, the laboratory test results for bilirubin, SGOT, SGPT fully correlated with the macro/microscopical findings.
1 context sentence(design, population, supporting numbers)
Summary · context
The hepatoprotective effects of a newly synthesized 15 amino acid fragment code named BPC 157 was evaluated in comparison with the reference standards (bromocriptine, amantadine and somatostatin) in various experimental models of liver injury in rats: 24 h-bile duct+hepatic artery ligation 48 h-rest…
Report a problemFND-0790172404
05AnimalAnimal study (in vivo)Efficacy outcome
In rats with experimental liver injury, SGOT results fully correlated with the macroscopic and microscopic findings.
In plain wordsIn rats with liver injury, blood SGOT results matched the tissue findings.
Peptide
BPC-157
Outcome
Direction not reportedSerum SGOT
Study
ratn: not reported in source
Liver injury models
Outcome group
Liver fat and liver function · Liver
Studied dose
Dose not stated · intragastric or intraperitonealAs given in this study (rat).
Source sentences
Summary
Noteworthy, the laboratory test results for bilirubin, SGOT, SGPT fully correlated with the macro/microscopical findings.
1 context sentence(design, population, supporting numbers)
Summary · context
The hepatoprotective effects of a newly synthesized 15 amino acid fragment code named BPC 157 was evaluated in comparison with the reference standards (bromocriptine, amantadine and somatostatin) in various experimental models of liver injury in rats: 24 h-bile duct+hepatic artery ligation 48 h-rest…
Report a problemFND-0790172405
06AnimalAnimal study (in vivo)Efficacy outcome
In rats with experimental liver injury, SGPT results fully correlated with the macroscopic and microscopic findings.
In plain wordsIn rats with liver injury, blood SGPT results matched the tissue findings.
Peptide
BPC-157
Outcome
Direction not reportedSerum SGPT
Study
ratn: not reported in source
Liver injury models
Outcome group
Liver fat and liver function · Liver
Studied dose
Dose not stated · intragastric or intraperitonealAs given in this study (rat).
Source sentences
Summary
Noteworthy, the laboratory test results for bilirubin, SGOT, SGPT fully correlated with the macro/microscopical findings.
1 context sentence(design, population, supporting numbers)
Summary · context
The hepatoprotective effects of a newly synthesized 15 amino acid fragment code named BPC 157 was evaluated in comparison with the reference standards (bromocriptine, amantadine and somatostatin) in various experimental models of liver injury in rats: 24 h-bile duct+hepatic artery ligation 48 h-rest…
Report a problemFND-0790172406

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
9 Oct 2026, 18:17 UTC
Study results updated
Version 2
9 Oct 2026, 03:03 UTC
Study data updated · source update from Europe PMC
Version 1
9 Oct 2026, 02:56 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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