Skip to content

Study · Measured the body's own peptide · 1994

3 results

Modulation of cellular gene expression of HIV type 1 infection as determined by subtractive hybridization cloning: downregulation of thymosin beta 4 in vitro and in vivo.

Shahabuddin M, McKinley G, Potash MJ, Volsky DJ

AIDS research and human retroviruses1 Nov 1994Cited by 6 (Europe PMC)

PMID7888207 (opens in a new tab)DOI10.1089/aid.1994.10.1525 (opens in a new tab)PepBankPUB-07888207
Publisher pagePubMedAsk about this study
Jump to 3 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyMechanism

    In lymphocytes of five AIDS patients, thymosin beta‑4 mRNA was reduced by up to fivefold.

    In plain wordsIn five people with AIDS, the body's own thymosin beta‑4 mRNA in lymphocytes was up to five times lower.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseThymosin beta 4 mRNA in lymphocytes of AIDS patients
    Study

    n = 5

    Outcome group
    Gene expression · Infection

    Source sentences

    Summary
    Northern blot analysis of RNA samples from lymphocytes of five AIDS patients reveals an up to fivefold reduction in the level of thymosin beta 4 mRNA.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  2. 02LabEndogenous levelIn vitro (cells)Mechanism

    In HIV-1-infected CEM cells and other infected T cells and macrophages in vitro, thymosin beta‑4 gene transcription was reduced two- to threefold.

    In plain wordsIn lab-grown cells infected with HIV-1, the cells' own thymosin beta‑4 gene was read two to three times less.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseThymosin beta 4 transcription in HIV-1-infected cells
    Study

    humann: not reported in source

    HIV-1-infected CEM cells, other T cells and macrophages
    Comparator
    Uninfected cells
    Outcome group
    Gene expression · Infection

    Source sentences

    Summary
    The gene encoding thymosin beta 4, a ubiquitous polypeptide associated with hematopoietic differentiation, showed two- to threefold reduced transcription in HIV-1-infected CEM cells and other HIV-1-infected T cells and macrophages in vitro.
    1 context sentence
    Summary · context
    We used subtractive hybridization cloning to identify genes whose expression is modulated by HIV-1 infection in the T leukemia cell line CEM.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  3. 03LabEndogenous levelIn vitro (cells)Mechanism

    Solid-phase radioimmunoassay showed about a threefold decrease in thymosin beta‑4 protein in lysates of HIV-1-infected cells.

    In plain wordsIn lab-grown cells infected with HIV-1, the cells' own thymosin beta‑4 protein was about three times lower.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseThymosin beta 4 protein in infected cell lysates
    Study

    humann: not reported in source

    Lysates of HIV-1-infected cells
    Comparator
    Uninfected cells
    Outcome group
    Gene expression · Infection

    Source sentences

    Summary
    Solid-phase radioimmunoassay revealed about a threefold decrease in the level of thymosin beta 4 protein in lysates of infected cells.
    1 context sentence
    Summary · context
    We used subtractive hybridization cloning to identify genes whose expression is modulated by HIV-1 infection in the T leukemia cell line CEM.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.