Skip to content

Study · Non-randomized trial · n = 6 · 1995

3 results

Metabolic modulation of the growth hormone-releasing activity of hexarelin in man.

Maccario M, Arvat E, Procopio M, Gianotti L, Grottoli S, Imbimbo BP, Lenaerts V, Deghenghi R, Camanni F, Ghigo E

Metabolism: clinical and experimental1 Jan 1995Cited by 34 (Europe PMC)

PMID7854159 (opens in a new tab)DOI10.1016/0026-0495(95)90300-3 (opens in a new tab)PepBankPUB-07854159
Publisher pagePubMedAsk about this study
Jump to 3 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

1 result from studies that gave the peptide. 1 result from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In normal men, hexarelin elicited a clear GH response that was higher than the response to GHRH.

    In plain wordsIn healthy men, hexarelin raised GH more than GHRH did.

    Peptide
    Hexarelin
    Outcome
    IncreasePeak GH after hexarelin versus GHRH
    Study

    n = 6

    Comparator
    GHRH 2 micrograms/kg iv
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    2 micrograms/kg · intravenousAs given in this study (human).

    Measurements

    Peak GH
    62.6 micrograms/L
    hexarelin
    Peak GH
    19.8 micrograms/L
    GHRH

    Source sentences

    Summary
    Hexarelin elicited a clear-cut GH response (mean +/- SEM; peak, 62.6 +/- 8.0 micrograms/L) that was higher (P < .01) than that observed after GHRH (peak, 19.8 +/- 2.4 micrograms/L).
    1 context sentence
    Summary · context
    Therefore, we investigated the effect of oral glucose (100 g) and lipid-heparin infusion (250 mL of a 10% lipid solution + 2,500 U heparin) on the GH response to a maximal dose (2 micrograms/kg intravenously [IV]) of hexarelin or GHRH in six normal men.

Studies that did not test the peptide alone2

In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Hexarelin.

  1. 02HumanNot a test of Hexarelin aloneNon-randomized trialEfficacy outcome

    In normal men, oral glucose blunted but did not abolish the GH response to hexarelin.

    In plain wordsIn healthy men, a sugar drink reduced the GH rise caused by hexarelin but did not stop it.

    Peptide
    Hexarelin
    Outcome
    DecreaseEffect of oral glucose on the GH response to hexarelin
    Study

    n = 6

    Comparator
    Hexarelin without glucose
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Measurements

    Peak GH
    38.4 micrograms/L
    hexarelin after oral glucose

    Source sentences

    Summary
    Although similar increases in plasma glucose were observed with the two peptides, oral glucose almost abolished the GH response to GHRH (peak, 5.6 +/- 0.9 micrograms/L, P < .01) while only blunting the somatotrope response to hexarelin (peak, 38.4 +/- 7.9 micrograms/L, P < .05).
    1 context sentence
    Summary · context
    Therefore, we investigated the effect of oral glucose (100 g) and lipid-heparin infusion (250 mL of a 10% lipid solution + 2,500 U heparin) on the GH response to a maximal dose (2 micrograms/kg intravenously [IV]) of hexarelin or GHRH in six normal men.

    In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.

  2. 03HumanNot a test of Hexarelin aloneNon-randomized trialEfficacy outcome

    In normal men, lipid-heparin infusion blunted but did not abolish the GH response to hexarelin.

    In plain wordsIn healthy men, a fat infusion reduced the GH rise caused by hexarelin but did not stop it.

    Peptide
    Hexarelin
    Outcome
    DecreaseEffect of lipid-heparin infusion on the GH response to hexarelin
    Study

    n = 6

    Comparator
    Hexarelin without lipid-heparin
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Measurements

    Peak GH
    34.2 micrograms/L
    hexarelin after lipid-heparin

    Source sentences

    Summary
    Similarly, lipid-heparin infusion nearly abolished the GH response to GHRH (peak, 4.9 +/- 1.0 micrograms/L, P < .01) while only blunting the somatotrope response to hexarelin (peak, 34.2 +/- 4.5 micrograms/L, P < .05).(ABSTRACT TRUNCATED AT 250 WORDS)
    1 context sentence
    Summary · context
    Therefore, we investigated the effect of oral glucose (100 g) and lipid-heparin infusion (250 mL of a 10% lipid solution + 2,500 U heparin) on the GH response to a maximal dose (2 micrograms/kg intravenously [IV]) of hexarelin or GHRH in six normal men.

    In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.