Final height in girls with central precocious puberty: comparison of two different luteinizing hormone-releasing hormone agonist treatments.

Antoniazzi F, Cisternino M, Nizzoli G, Bozzola M, Corrias A, De Luca F, De Sanctis C, Rigon F, Zamboni G, Bernasconi S

Acta paediatrica (Oslo, Norway : 1992)1 Oct 1994Cited by 30 (Europe PMC)

PMID7841703DOI10.1111/j.1651-2227.1994.tb12984.xPepBankPUB-07841703

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

01HumanObservational studyEfficacy outcome
In girls with central precocious puberty, triptorelin treatment was associated with significantly greater final height than buserelin treatment.
In plain wordsIn girls with early puberty, triptorelin treatment was linked to greater final height than buserelin treatment.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseFinal height versus buserelin
Study
n = 30
Comparator
Intranasal buserelin
Outcome group
Linear growth · Endocrine and hormones
Studied dose
Dose not stated · intramuscularAs given in this study (human).
Measurements
Final height
160.6 cm
triptorelin
Final height
153.2 cm
buserelin
Source sentences
Summary
Final height in group B (160.6 +/- 5.7 cm) was significantly higher than that of group A (153.2 +/- 5.0 cm: p < 0.05) and group C (149.6 +/- 6.3; p < 0.01), whereas the difference between groups A and C was not statistically significant.
1 context sentence(design, population, supporting numbers)
Summary · context
we analyzed growth data from 40 girls (15 treated with buserelin intranasal spray (group A), 15 treated with triptorelin depot im every 28 days (group B) and 10 untreated (group C)).
Report a problemFND-0784170302
02HumanObservational studyEfficacy outcome
In girls with central precocious puberty, triptorelin treatment was associated with significantly greater final height than no treatment.
In plain wordsIn girls with early puberty, triptorelin treatment was linked to greater final height than no treatment.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseFinal height versus untreated girls
Study
n = 25
Comparator
Untreated girls
Outcome group
Linear growth · Endocrine and hormones
Studied dose
Dose not stated · intramuscularAs given in this study (human).
Measurements
Final height
160.6 cm
triptorelin
Final height
149.6 cm
untreated
Source sentences
Summary
Final height in group B (160.6 +/- 5.7 cm) was significantly higher than that of group A (153.2 +/- 5.0 cm: p < 0.05) and group C (149.6 +/- 6.3; p < 0.01), whereas the difference between groups A and C was not statistically significant.
1 context sentence(design, population, supporting numbers)
Summary · context
we analyzed growth data from 40 girls (15 treated with buserelin intranasal spray (group A), 15 treated with triptorelin depot im every 28 days (group B) and 10 untreated (group C)).
Report a problemFND-0784170303
03HumanObservational studyEfficacy outcome
In girls with central precocious puberty, triptorelin appeared to control precocious puberty.
In plain wordsIn girls with early puberty, triptorelin appeared to control puberty.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
Not applicablePrecocious puberty control
Study
n = 15
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated · intramuscularAs given in this study (human).
Source sentences
Summary
Both luteinizing hormone-releasing hormone agonists appeared to control precocious puberty.
1 context sentence(design, population, supporting numbers)
Summary · context
we analyzed growth data from 40 girls (15 treated with buserelin intranasal spray (group A), 15 treated with triptorelin depot im every 28 days (group B) and 10 untreated (group C)).
Report a problemFND-0784170301
04HumanObservational studyEfficacy outcome
In triptorelin-treated girls, final height exceeded target height numerically, but the difference was not significant.
In plain wordsIn triptorelin-treated girls, final height did not differ significantly from target height.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeFinal height versus target height
Study
n = 15
Comparator
Target height
Outcome group
Linear growth · Endocrine and hormones
Studied dose
Dose not stated · intramuscularAs given in this study (human).
Measurements
Final height
160.6 cm
triptorelin
Target height
157.6 cm
triptorelin group
Source sentences
Summary
In group B a positive difference was observed between final height (160.6 +/- 5.7 cm) and target height (157.6 +/- 5.9 cm) (ns)
1 context sentence(design, population, supporting numbers)
Summary · context
we analyzed growth data from 40 girls (15 treated with buserelin intranasal spray (group A), 15 treated with triptorelin depot im every 28 days (group B) and 10 untreated (group C)).
Report a problemFND-0784170304

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PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

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