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Study · Animal study (in vivo) · rat · 1994

3 results

Nasal absorption of desmopressin in rats and sheep. Effect of a bioadhesive microsphere delivery system.

Critchley H, Davis SS, Farraj NF, Illum L

The Journal of pharmacy and pharmacology1 Aug 1994Cited by 51 (Europe PMC)

PMID7815278 (opens in a new tab)DOI10.1111/j.2042-7158.1994.tb03876.x (opens in a new tab)PepBankPUB-07815278
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Pharmacokinetics

    In rats, nasal desmopressin bioavailability was 13 times higher than in sheep.

    In plain wordsIn rats, nasal desmopressin bioavailability was 13 times higher than in sheep.

    Peptide
    Desmopressin
    Outcome
    IncreaseNasal bioavailability
    Study

    ratn: not reported in source

    Rat nasal absorption model
    Comparator
    Sheep model
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · nasalAs given in this study (rat).

    Measurements

    Bioavailability ratio
    13 fold
    rat versus sheep

    Source sentences

    Summary
    The bioavailability after nasal administration was found to be 13 times higher in the rat model.
    1 context sentence
    Summary · context
    The nasal absorption of desmopressin was studied in two animal models, the rat and the sheep.

Studies that did not test the peptide alone2

In this study, Desmopressin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Desmopressin.

  1. 02AnimalNot a test of Desmopressin aloneAnimal study (in vivo)Pharmacokinetics

    In sheep, desmopressin microspheres, especially with LPC, reached nearly 10% bioavailability versus 1.2% with a simple solution.

    In plain wordsIn sheep, desmopressin microspheres, especially with LPC, had higher bioavailability than a simple nasal solution.

    Peptide
    Desmopressin
    Outcome
    IncreaseNasal bioavailability with microspheres
    Study

    sheepn: not reported in source

    Sheep nasal absorption model
    Comparator
    Simple nasal desmopressin solution
    Outcome group
    Pharmacokinetics · Pharmacology

    Measurements

    Bioavailability
    ≈ 10%
    microspheres especially with LPC
    Bioavailability
    1.2%
    simple solution

    Source sentences

    Summary
    The use of the bioadhesive starch microsphere delivery system, especially in combination with LPC, had a profound effect on the absorption of desmopressin in sheep, with bioavailabilities reaching nearly 10% compared with 1.2% for a simple nasal solution of desmopressin.
    1 context sentence
    Summary · context
    The nasal absorption of desmopressin was studied in two animal models, the rat and the sheep.

    In this study, Desmopressin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Desmopressin.

  2. 03AnimalNot a test of Desmopressin aloneAnimal study (in vivo)Pharmacokinetics

    In sheep, adding LPC to nasal desmopressin formulations had the most pronounced absorption-enhancing effect among the animal models.

    In plain wordsIn sheep, adding LPC enhanced desmopressin absorption most strongly among the animal models.

    Peptide
    Desmopressin
    Outcome
    IncreaseAbsorption enhancement with LPC
    Study

    sheepn: not reported in source

    Sheep nasal absorption model
    Comparator
    Formulations without LPC
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    The effect of the addition of L-alpha-lysophosphatidylcholine (LPC) to the formulations as an absorption enhancer was most pronounced in the sheep model.
    1 context sentence
    Summary · context
    The nasal absorption of desmopressin was studied in two animal models, the rat and the sheep.

    In this study, Desmopressin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Desmopressin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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