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Study · Animal study (in vivo) · rat · 1995

13 results

Expression of gonadotropin-releasing hormone (GnRH) receptor gene is altered by GnRH agonist desensitization in a manner similar to that of gonadotropin beta-subunit genes in normal and castrated rat pituitary.

Lerrant Y, Kottler ML, Bergametti F, Moumni M, Blumberg-Tick J, Counis R

Endocrinology1 Jul 1995Cited by 51 (Europe PMC)

PMID7789305 (opens in a new tab)DOI10.1210/endo.136.7.7789305 (opens in a new tab)PepBankPUB-07789305
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study13

13 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In male rats, triptorelin rapidly reduced pituitary GnRH receptor mRNA to 20-25% of its initial level by 5 hours.

    In plain wordsIn rats, triptorelin rapidly lowered pituitary GnRH receptor messenger RNA.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseGnRH receptor mRNA acute decrease
    Study

    ratn: not reported in source

    Normal and castrated male rats
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    300 micrograms/kg long-acting formulationAs given in this study (rat).

    Measurements

    Residual GnRH receptor mRNA
    20 to 25%
    initial level at 5 h

    Source sentences

    Summary
    A rapid time-dependent decrease in the level of GnRH-R mRNA was observed in rats after triptorelin administration. A minimum residual level of mRNA, in the range of 20-25% of the initial value, was attained as early as 5 h after treatment.
    1 context sentence
    Summary · context
    To examine the desensitizing effects of GnRH agonist on the expression of the pituitary GnRH receptor (GnRH-R) gene, male rats were given triptorelin (long-acting formulation, 300 micrograms/kg), and levels of GnRH-R messenger RNA (mRNA) were determined by Northern and dot blot hybridization to a 32…
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats after triptorelin, GnRH receptor mRNA stabilized at 25-30% after a transient increase to 45% on day 5.

    In plain wordsIn rats after triptorelin, GnRH receptor messenger RNA briefly increased, then stabilized below its initial level.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    MixedGnRH receptor mRNA later time course
    Study

    ratn: not reported in source

    Normal and castrated male rats
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    300 micrograms/kg long-acting formulationAs given in this study (rat).

    Measurements

    Stabilized mRNA
    25 to 30%
    after transient increase
    Transient mRNA
    45%
    day 5

    Source sentences

    Summary
    Levels further stabilized to 25-30% after a small transient increase to 45% on day 5.
    1 context sentence
    Summary · context
    To examine the desensitizing effects of GnRH agonist on the expression of the pituitary GnRH receptor (GnRH-R) gene, male rats were given triptorelin (long-acting formulation, 300 micrograms/kg), and levels of GnRH-R messenger RNA (mRNA) were determined by Northern and dot blot hybridization to a 32…
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats, one triptorelin injection suppressed GnRH receptor mRNA for at least 30 days before levels slowly normalized.

    In plain wordsIn rats, one triptorelin injection suppressed GnRH receptor messenger RNA for at least 30 days.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseDuration of GnRH receptor mRNA suppression
    Study

    ratn: not reported in source

    Normal and castrated male rats
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    300 micrograms/kg long-acting formulationAs given in this study (rat).

    Source sentences

    Summary
    A single injection was effective for at least 30 days, after which GnRH-R mRNA levels slowly returned to normal, suggesting a progressive abolition of agonist effects.
    1 context sentence
    Summary · context
    To examine the desensitizing effects of GnRH agonist on the expression of the pituitary GnRH receptor (GnRH-R) gene, male rats were given triptorelin (long-acting formulation, 300 micrograms/kg), and levels of GnRH-R messenger RNA (mRNA) were determined by Northern and dot blot hybridization to a 32…
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats, triptorelin reduced LH beta mRNA by 50% in about 48 hours.

    In plain wordsIn rats, triptorelin reduced LH beta messenger RNA by 50% in about 48 hours.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseLH beta mRNA acute depletion
    Study

    ratn: not reported in source

    Normal and castrated male rats
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    300 micrograms/kg long-acting formulationAs given in this study (rat).

    Measurements

    LH beta mRNA decrease
    50%
    about 48 h

    Source sentences

    Summary
    A concomitant acute depletion of mRNA levels was observed for LH beta and FSH beta (50% decrease in about 48 and 3 h, respectively)
    1 context sentence
    Summary · context
    To examine the desensitizing effects of GnRH agonist on the expression of the pituitary GnRH receptor (GnRH-R) gene, male rats were given triptorelin (long-acting formulation, 300 micrograms/kg), and levels of GnRH-R messenger RNA (mRNA) were determined by Northern and dot blot hybridization to a 32…
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats, triptorelin reduced FSH beta mRNA by 50% in about 3 hours.

    In plain wordsIn rats, triptorelin reduced FSH beta messenger RNA by 50% in about 3 hours.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseFSH beta mRNA acute depletion
    Study

    ratn: not reported in source

    Normal and castrated male rats
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    300 micrograms/kg long-acting formulationAs given in this study (rat).

    Measurements

    FSH beta mRNA decrease
    50%
    about 3 h

    Source sentences

    Summary
    A concomitant acute depletion of mRNA levels was observed for LH beta and FSH beta (50% decrease in about 48 and 3 h, respectively)
    1 context sentence
    Summary · context
    To examine the desensitizing effects of GnRH agonist on the expression of the pituitary GnRH receptor (GnRH-R) gene, male rats were given triptorelin (long-acting formulation, 300 micrograms/kg), and levels of GnRH-R messenger RNA (mRNA) were determined by Northern and dot blot hybridization to a 32…
  6. 06AnimalAnimal study (in vivo)Mechanism

    In rats, triptorelin increased gonadotropin alpha-subunit mRNA to 1.8-fold control levels after 1-2 days.

    In plain wordsIn rats, triptorelin increased gonadotropin alpha-subunit messenger RNA compared with control rats.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseGonadotropin alpha-subunit mRNA
    Study

    ratn: not reported in source

    Normal and castrated male rats
    Comparator
    Control rats
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    300 micrograms/kg long-acting formulationAs given in this study (rat).

    Measurements

    Alpha-subunit mRNA
    1.8 fold
    control level after 1-2 days

    Source sentences

    Summary
    whereas the alpha-subunit message increased (rapidly reaching a level 1.8-fold that in control rats after 1-2 days).
    1 context sentence
    Summary · context
    To examine the desensitizing effects of GnRH agonist on the expression of the pituitary GnRH receptor (GnRH-R) gene, male rats were given triptorelin (long-acting formulation, 300 micrograms/kg), and levels of GnRH-R messenger RNA (mRNA) were determined by Northern and dot blot hybridization to a 32…
  7. 07AnimalAnimal study (in vivo)Mechanism

    In rats, triptorelin prevented the castration-induced increase in GnRH receptor mRNA for as long as 3 weeks.

    In plain wordsIn rats, triptorelin prevented the rise in GnRH receptor messenger RNA after castration.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreasePrevention of castration-induced GnRH receptor mRNA elevation
    Study

    ratn: not reported in source

    Normal and castrated male rats
    Comparator
    Castrated rats without GnRH agonist treatment
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    300 micrograms/kg long-acting formulation · 3 weeksAs given in this study (rat).

    Source sentences

    Summary
    Administration of the GnRH agonist readily prevented, for as long as 3 weeks, the stimulatory effects of castration on the GnRH-R mRNA and mRNAs for the beta-subunit of gonadotropins, but not for the alpha mRNA, which remained at a high level.
    1 context sentence
    Summary · context
    To examine the desensitizing effects of GnRH agonist on the expression of the pituitary GnRH receptor (GnRH-R) gene, male rats were given triptorelin (long-acting formulation, 300 micrograms/kg), and levels of GnRH-R messenger RNA (mRNA) were determined by Northern and dot blot hybridization to a 32…
  8. 08AnimalAnimal study (in vivo)Mechanism

    In rats, triptorelin prevented the castration-induced increase in gonadotropin LH beta-subunit mRNA for as long as 3 weeks.

    In plain wordsIn rats, triptorelin prevented the rise in LH beta messenger RNA after castration.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreasePrevention of castration-induced LH beta mRNA elevation
    Study

    ratn: not reported in source

    Normal and castrated male rats
    Comparator
    Castrated rats without GnRH agonist treatment
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    300 micrograms/kg long-acting formulation · 3 weeksAs given in this study (rat).

    Source sentences

    Summary
    Administration of the GnRH agonist readily prevented, for as long as 3 weeks, the stimulatory effects of castration on the GnRH-R mRNA and mRNAs for the beta-subunit of gonadotropins, but not for the alpha mRNA, which remained at a high level.
    2 context sentences
    Summary · context
    Abundances of gonadotropin alpha-subunit, LH beta, and FSH beta mRNAs were examined in parallel, using appropriate probes.
    Summary · context
    To examine the desensitizing effects of GnRH agonist on the expression of the pituitary GnRH receptor (GnRH-R) gene, male rats were given triptorelin (long-acting formulation, 300 micrograms/kg), and levels of GnRH-R messenger RNA (mRNA) were determined by Northern and dot blot hybridization to a 32…
  9. 09AnimalAnimal study (in vivo)Mechanism

    In rats, triptorelin prevented the castration-induced increase in gonadotropin FSH beta-subunit mRNA for as long as 3 weeks.

    In plain wordsIn rats, triptorelin prevented the rise in FSH beta messenger RNA after castration.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreasePrevention of castration-induced FSH beta mRNA elevation
    Study

    ratn: not reported in source

    Normal and castrated male rats
    Comparator
    Castrated rats without GnRH agonist treatment
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    300 micrograms/kg long-acting formulation · 3 weeksAs given in this study (rat).

    Source sentences

    Summary
    Administration of the GnRH agonist readily prevented, for as long as 3 weeks, the stimulatory effects of castration on the GnRH-R mRNA and mRNAs for the beta-subunit of gonadotropins, but not for the alpha mRNA, which remained at a high level.
    2 context sentences
    Summary · context
    Abundances of gonadotropin alpha-subunit, LH beta, and FSH beta mRNAs were examined in parallel, using appropriate probes.
    Summary · context
    To examine the desensitizing effects of GnRH agonist on the expression of the pituitary GnRH receptor (GnRH-R) gene, male rats were given triptorelin (long-acting formulation, 300 micrograms/kg), and levels of GnRH-R messenger RNA (mRNA) were determined by Northern and dot blot hybridization to a 32…
  10. 10AnimalAnimal study (in vivo)Mechanism

    In castrated rats, triptorelin did not prevent elevated gonadotropin alpha-subunit mRNA, which remained high.

    In plain wordsIn rats, triptorelin did not prevent high gonadotropin alpha-subunit messenger RNA after castration.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changeAlpha-subunit mRNA after castration
    Study

    ratn: not reported in source

    Normal and castrated male rats
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    300 micrograms/kg long-acting formulationAs given in this study (rat).

    Source sentences

    Summary
    Administration of the GnRH agonist readily prevented, for as long as 3 weeks, the stimulatory effects of castration on the GnRH-R mRNA and mRNAs for the beta-subunit of gonadotropins, but not for the alpha mRNA, which remained at a high level.
    1 context sentence
    Summary · context
    To examine the desensitizing effects of GnRH agonist on the expression of the pituitary GnRH receptor (GnRH-R) gene, male rats were given triptorelin (long-acting formulation, 300 micrograms/kg), and levels of GnRH-R messenger RNA (mRNA) were determined by Northern and dot blot hybridization to a 32…
  11. 11AnimalAnimal study (in vivo)Mechanism

    In rats treated 3 weeks after castration, triptorelin totally abolished the induced LH beta mRNA increase.

    In plain wordsIn rats treated after castration, triptorelin abolished the rise in LH beta messenger RNA.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseReversal of postoperative LH beta mRNA elevation
    Study

    ratn: not reported in source

    Normal and castrated male rats
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    300 micrograms/kg long-acting formulationAs given in this study (rat).

    Source sentences

    Summary
    When triptorelin was administered 3 weeks postoperatively, the castration-induced increase in LH beta and FSH beta was totally abolished, and no significant effect was noted on alpha-subunit mRNA.
    1 context sentence
    Summary · context
    To examine the desensitizing effects of GnRH agonist on the expression of the pituitary GnRH receptor (GnRH-R) gene, male rats were given triptorelin (long-acting formulation, 300 micrograms/kg), and levels of GnRH-R messenger RNA (mRNA) were determined by Northern and dot blot hybridization to a 32…
  12. 12AnimalAnimal study (in vivo)Mechanism

    In rats treated 3 weeks after castration, triptorelin totally abolished the induced FSH beta mRNA increase.

    In plain wordsIn rats treated after castration, triptorelin abolished the rise in FSH beta messenger RNA.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseReversal of postoperative FSH beta mRNA elevation
    Study

    ratn: not reported in source

    Normal and castrated male rats
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    300 micrograms/kg long-acting formulationAs given in this study (rat).

    Source sentences

    Summary
    When triptorelin was administered 3 weeks postoperatively, the castration-induced increase in LH beta and FSH beta was totally abolished, and no significant effect was noted on alpha-subunit mRNA.
    1 context sentence
    Summary · context
    To examine the desensitizing effects of GnRH agonist on the expression of the pituitary GnRH receptor (GnRH-R) gene, male rats were given triptorelin (long-acting formulation, 300 micrograms/kg), and levels of GnRH-R messenger RNA (mRNA) were determined by Northern and dot blot hybridization to a 32…
  13. 13AnimalAnimal study (in vivo)Mechanism

    In rats treated 3 weeks after castration, triptorelin had no significant effect on alpha-subunit mRNA.

    In plain wordsIn rats treated after castration, triptorelin did not significantly change alpha-subunit messenger RNA.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    No significant changePostoperative alpha-subunit mRNA
    Study

    ratn: not reported in source

    Normal and castrated male rats
    Outcome group
    Receptor activity and mechanism · Endocrine and hormones
    Studied dose
    300 micrograms/kg long-acting formulationAs given in this study (rat).

    Source sentences

    Summary
    When triptorelin was administered 3 weeks postoperatively, the castration-induced increase in LH beta and FSH beta was totally abolished, and no significant effect was noted on alpha-subunit mRNA.
    1 context sentence
    Summary · context
    To examine the desensitizing effects of GnRH agonist on the expression of the pituitary GnRH receptor (GnRH-R) gene, male rats were given triptorelin (long-acting formulation, 300 micrograms/kg), and levels of GnRH-R messenger RNA (mRNA) were determined by Northern and dot blot hybridization to a 32…

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

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