A randomized, comparative trial of triptorelin depot (D-Trp6-LHRH) and danazol in the treatment of endometriosis.

Cirkel U, Ochs H, Schneider HP

European journal of obstetrics, gynecology, and reproductive biology1 Mar 1995Cited by 33 (Europe PMC)

PMID7781864DOI10.1016/0028-2243(94)02016-8PepBankPUB-07781864

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. 7 results from people.

01HumanRandomized controlled trialEfficacy outcome
In women with endometriosis, triptorelin suppressed estradiol significantly more than danazol.
In plain wordsIn women with endometriosis, triptorelin lowered estradiol more than danazol.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseEstradiol suppression
Study
n = 55
Comparator
Danazol
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · 24 weeksAs given in this study (human).
Source sentences
Summary
Estradiol suppression was significantly more pronounced with triptorelin, while the free androgenic index rose with danazol.
1 context sentence(design, population, supporting numbers)
Summary · context
To compare treatment efficacy and safety parameters a total of 55 premenopausal women with histologically proven endometriosis (stage II-IV) were randomized to receive the LHRH-analogue depot triptorelin (n = 30) or the steroid danazol (n = 25) for a total of 24 weeks.
Report a problemFND-0778186401
02HumanRandomized controlled trialEfficacy outcome
In women with endometriosis, triptorelin and danazol similarly reduced implants, by 58% and 51%, respectively.
In plain wordsIn women with endometriosis, triptorelin and danazol reduced implants similarly.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeEndometriotic implant reduction
Study
n = 55
Comparator
Danazol
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · 24 weeksAs given in this study (human).
Measurements
Implant reduction
58%
triptorelin
Implant reduction
51%
danazol
Source sentences
Summary
Both substances were equally effective in reducing endometriotic implants (58% and 51%, respectively).
1 context sentence(design, population, supporting numbers)
Summary · context
To compare treatment efficacy and safety parameters a total of 55 premenopausal women with histologically proven endometriosis (stage II-IV) were randomized to receive the LHRH-analogue depot triptorelin (n = 30) or the steroid danazol (n = 25) for a total of 24 weeks.
Report a problemFND-0778186402
03HumanRandomized controlled trialEfficacy outcome
In women with endometriosis, dyspareunia decreased by at least 50% during the compared endocrine treatments.
In plain wordsIn women with endometriosis, pain during sex decreased by at least 50% during the compared treatments.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseDyspareunia
Study
n = 55
Outcome group
Pain · Reproductive and sexual health
Studied dose
Dose not stated · 24 weeksAs given in this study (human).
Measurements
Dyspareunia decrease
≥ 50%
compared endocrine treatments
Source sentences
Summary
Dyspareunia and pelvic pain decreased at least by 50%.
1 context sentence(design, population, supporting numbers)
Summary · context
To compare treatment efficacy and safety parameters a total of 55 premenopausal women with histologically proven endometriosis (stage II-IV) were randomized to receive the LHRH-analogue depot triptorelin (n = 30) or the steroid danazol (n = 25) for a total of 24 weeks.
Report a problemFND-0778186404
04HumanRandomized controlled trialEfficacy outcome
In women with endometriosis, pelvic pain decreased by at least 50% during the compared endocrine treatments.
In plain wordsIn women with endometriosis, pelvic pain decreased by at least 50% during the compared treatments.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreasePelvic pain
Study
n = 55
Outcome group
Pain · Reproductive and sexual health
Studied dose
Dose not stated · 24 weeksAs given in this study (human).
Measurements
Pelvic pain decrease
≥ 50%
compared endocrine treatments
Source sentences
Summary
Dyspareunia and pelvic pain decreased at least by 50%.
1 context sentence(design, population, supporting numbers)
Summary · context
To compare treatment efficacy and safety parameters a total of 55 premenopausal women with histologically proven endometriosis (stage II-IV) were randomized to receive the LHRH-analogue depot triptorelin (n = 30) or the steroid danazol (n = 25) for a total of 24 weeks.
Report a problemFND-0778186405
05HumanRandomized controlled trialEfficacy outcome
In women with endometriosis, dysmenorrhea was absent after triptorelin treatment, as in the danazol group.
In plain wordsIn women with endometriosis, menstrual pain was absent after triptorelin treatment, as after danazol.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseDysmenorrhea
Study
n = 30
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
Dose not stated · 24 weeksAs given in this study (human).
Source sentences
Summary
Dysmenorrhea was absent at the end of medical therapy in both treatment groups.
1 context sentence(design, population, supporting numbers)
Summary · context
To compare treatment efficacy and safety parameters a total of 55 premenopausal women with histologically proven endometriosis (stage II-IV) were randomized to receive the LHRH-analogue depot triptorelin (n = 30) or the steroid danazol (n = 25) for a total of 24 weeks.
Report a problemFND-0778186403
06HumanRandomized controlled trialSafety outcome
In women with endometriosis, triptorelin markedly increased the urinary calcium/creatinine ratio.
In plain wordsIn women with endometriosis, the urine calcium/creatinine ratio increased markedly during triptorelin treatment.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseUrinary calcium/creatinine ratio
Study
n = 30
Outcome group
Adverse events · Kidney and urinary
Studied dose
Dose not stated · 24 weeksAs given in this study (human).
Source sentences
Summary
while the urinary calcium/creatinine ratio showed a marked elevation with triptorelin.
1 context sentence(design, population, supporting numbers)
Summary · context
To compare treatment efficacy and safety parameters a total of 55 premenopausal women with histologically proven endometriosis (stage II-IV) were randomized to receive the LHRH-analogue depot triptorelin (n = 30) or the steroid danazol (n = 25) for a total of 24 weeks.
Report a problemFND-0778186406
07HumanRandomized controlled trialSafety outcome
In women with endometriosis, triptorelin adverse effects were mainly attributed to hypoestrogenism.
In plain wordsIn women with endometriosis, triptorelin side effects mainly reflected low estrogen.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
Not applicableHypoestrogenic adverse effects
Study
n = 30
Outcome group
Adverse events · Endocrine and hormones
Studied dose
Dose not stated · 24 weeksAs given in this study (human).
Source sentences
Summary
Adverse effects were mainly due to the hypoestrogenism of the LHRH analogue and the androgenic/anabolic properties of the steroid.
1 context sentence(design, population, supporting numbers)
Summary · context
To compare treatment efficacy and safety parameters a total of 55 premenopausal women with histologically proven endometriosis (stage II-IV) were randomized to receive the LHRH-analogue depot triptorelin (n = 30) or the steroid danazol (n = 25) for a total of 24 weeks.
Report a problemFND-0778186407

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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