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Study · Animal study (in vivo) · dog · 1995

4 results

Hexarelin, a potent GHRP analogue: interactions with GHRH and clonidine in young and aged dogs.

Cella SG, Locatelli V, Poratelli M, De Gennaro Colonna V, Imbimbo BP, Deghenghi R, Müller EE

Peptides1 Jan 1995Cited by 14 (Europe PMC)

PMID7716078 (opens in a new tab)DOI10.1016/0196-9781(94)00149-z (opens in a new tab)PepBankPUB-07716078
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In young and aged dogs, intravenous hexarelin stimulated GH secretion in a dose-dependent way.

    In plain wordsIn young and old dogs, hexarelin raised GH, and higher doses raised it more.

    Peptide
    Hexarelin
    Outcome
    IncreaseGH secretion after hexarelin
    Study

    dogn: not reported in source

    Unanesthetized young and aged dogs
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    15.6-250 micrograms/kg · intravenousAs given in this study (dog).

    Source sentences

    Summary
    Hexarelin (15.6-250 micrograms/kg, i.v.) significantly stimulated GH secretion in a dose-dependent fashion in dogs of both age groups.
    1 context sentence
    Summary · context
    The GH-releasing activity of hexarelin was evaluated in unanesthetized young and aged dogs.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In young and aged dogs, hexarelin strongly potentiated the GH-releasing effect of GHRH.

    In plain wordsIn young and old dogs, hexarelin strongly boosted the GH release caused by GHRH.

    Peptide
    Hexarelin
    Outcome
    IncreasePotentiation of GHRH-induced GH release in young and aged dogs
    Study

    dogn: not reported in source

    Unanesthetized young and aged dogs
    Comparator
    GHRH alone
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated · intravenousAs given in this study (dog).

    Source sentences

    Summary
    Hexarelin strikingly potentiated the effect of GHRH both in young and aged dogs, whereas it potentiated the effect of clonidine in young dogs only.
    2 context sentences
    Summary · context
    The ability of hexarelin to potentiate the GH-releasing effect of GHRH (2 micrograms/kg, i.v) and clonidine (4 micrograms/kg, i.v.) was then tested.
    Summary · context
    The GH-releasing activity of hexarelin was evaluated in unanesthetized young and aged dogs.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In young dogs, hexarelin potentiated the GH-releasing effect of clonidine.

    In plain wordsIn young dogs, hexarelin boosted the GH release caused by clonidine.

    Peptide
    Hexarelin
    Outcome
    IncreasePotentiation of clonidine-induced GH release in young dogs
    Study

    dogn: not reported in source

    Unanesthetized young and aged dogs
    Comparator
    Clonidine alone
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated · intravenousAs given in this study (dog).

    Source sentences

    Summary
    whereas it potentiated the effect of clonidine in young dogs only.
    2 context sentences
    Summary · context
    The ability of hexarelin to potentiate the GH-releasing effect of GHRH (2 micrograms/kg, i.v) and clonidine (4 micrograms/kg, i.v.) was then tested.
    Summary · context
    The GH-releasing activity of hexarelin was evaluated in unanesthetized young and aged dogs.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In aged dogs, hexarelin did not potentiate the GH-releasing effect of clonidine.

    In plain wordsIn old dogs, hexarelin did not boost the GH release caused by clonidine.

    Peptide
    Hexarelin
    Outcome
    No significant changePotentiation of clonidine-induced GH release in aged dogs
    Study

    dogn: not reported in source

    Unanesthetized young and aged dogs
    Comparator
    Clonidine alone
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated · intravenousAs given in this study (dog).

    Source sentences

    Summary
    whereas it potentiated the effect of clonidine in young dogs only.
    2 context sentences
    Summary · context
    The ability of hexarelin to potentiate the GH-releasing effect of GHRH (2 micrograms/kg, i.v) and clonidine (4 micrograms/kg, i.v.) was then tested.
    Summary · context
    The GH-releasing activity of hexarelin was evaluated in unanesthetized young and aged dogs.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 2

    13 Oct 2026, 16:31 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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