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Study · Non-randomized trial · n = 52 · 1995

7 results

Growth hormone-releasing activity of hexarelin, a new synthetic hexapeptide, before and during puberty.

Bellone J, Aimaretti G, Bartolotta E, Benso L, Imbimbo BP, Lenhaerts V, Deghenghi R, Camanni F, Ghigo E

The Journal of clinical endocrinology and metabolism1 Apr 1995Cited by 27 (Europe PMC)

PMID7714074 (opens in a new tab)DOI10.1210/jcem.80.4.7714074 (opens in a new tab)PepBankPUB-07714074
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. 7 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In prepubertal children, there was no sex-dependent difference in the GH response to hexarelin.

    In plain wordsBefore puberty, boys and girls did not differ in how much hexarelin raised their GH.

    Peptide
    Hexarelin
    Outcome
    No significant changeSex difference in GH response to hexarelin before puberty
    Study

    n = 52

    Comparator
    Boys versus girls
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Before puberty, there was no sex-dependent difference in the GH response to HEX.
    2 context sentences
    Summary · context
    Fifty-two of the children were prepubertal, and the other 44 were in pubertal stage II-IV.
    Summary · context
    Ninety-six children (54 boys and 42 girls, aged 4.1-17.4 yr) were studied.
  2. 02HumanNon-randomized trialEfficacy outcome

    In boys and girls in puberty, the GH response to hexarelin increased compared with the prepubertal response.

    In plain wordsDuring puberty, hexarelin raised GH more in both boys and girls.

    Peptide
    Hexarelin
    Outcome
    IncreaseGH response to hexarelin during puberty
    Study

    n = 44

    Comparator
    Prepubertal state
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    It increased during puberty (P < 0.05 and P < 0.002 for boys and girls, respectively), when it was higher (P < 0.05) in girls than in boys.
    2 context sentences
    Summary · context
    Fifty-two of the children were prepubertal, and the other 44 were in pubertal stage II-IV.
    Summary · context
    Ninety-six children (54 boys and 42 girls, aged 4.1-17.4 yr) were studied.
  3. 03HumanNon-randomized trialEfficacy outcome

    In pubertal children, the GH response to hexarelin was higher in girls than in boys.

    In plain wordsDuring puberty, hexarelin raised GH more in girls than in boys.

    Peptide
    Hexarelin
    Outcome
    IncreaseSex difference in GH response to hexarelin during puberty
    Study

    n = 44

    Comparator
    Boys
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    It increased during puberty (P < 0.05 and P < 0.002 for boys and girls, respectively), when it was higher (P < 0.05) in girls than in boys.
    2 context sentences
    Summary · context
    Fifty-two of the children were prepubertal, and the other 44 were in pubertal stage II-IV.
    Summary · context
    Ninety-six children (54 boys and 42 girls, aged 4.1-17.4 yr) were studied.
  4. 04HumanNon-randomized trialEfficacy outcome

    In children, oral hexarelin 10 mg had a greater GH-releasing effect than intravenous GHRH 1.0 microgram/kg.

    In plain wordsIn children, a 10 mg oral dose of hexarelin raised GH more than an injected dose of GHRH.

    Peptide
    Hexarelin
    Outcome
    IncreaseGH response to oral hexarelin versus GHRH
    Study

    n = 7

    Comparator
    GHRH 1.0 microgram/kg iv
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    10 mg · oralAs given in this study (human).

    Source sentences

    Summary
    The GH-releasing effect of 10 mg HEX, orally, was greater (P < 0.03) than that of 1.0 microgram/kg GHRH, iv (n = 7).
    1 context sentence
    Summary · context
    Ninety-six children (54 boys and 42 girls, aged 4.1-17.4 yr) were studied.
  5. 05HumanNon-randomized trialEfficacy outcome

    In children, intravenous hexarelin 2 micrograms/kg produced a higher GH response than intravenous GHRH 1 microgram/kg.

    In plain wordsIn children, hexarelin raised GH more than GHRH did.

    Peptide
    Hexarelin
    Outcome
    IncreaseGH response to hexarelin 2 micrograms/kg iv versus GHRH
    Study

    n: not reported in source

    Comparator
    GHRH 1 microgram/kg iv
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    2 micrograms/kg · intravenousAs given in this study (human).

    Measurements

    P value
    < 0.001
    hexarelin versus GHRH

    Source sentences

    Summary
    The GH response to 2 micrograms/kg HEX, iv (n = 56), was higher (P < 0.001) than that induced by 1 microgram/kg GHRH, iv (n = 33).
    1 context sentence
    Summary · context
    Ninety-six children (54 boys and 42 girls, aged 4.1-17.4 yr) were studied.
  6. 06HumanNon-randomized trialEfficacy outcome

    In children, the 2.0 microgram/kg intravenous dose of hexarelin induced a greater GH increase than the 1.0 microgram/kg dose.

    In plain wordsIn children, the higher hexarelin dose raised GH more than the lower dose.

    Peptide
    Hexarelin
    Outcome
    IncreaseGH response to hexarelin 2.0 versus 1.0 microgram/kg iv
    Study

    n: not reported in source

    Comparator
    Hexarelin 1.0 microgram/kg iv
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    2 micrograms/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    The iv dose of 2.0 micrograms/kg HEX induced a greater GH increase (P < 0.02) than the 1.0 microgram/kg dose.
    1 context sentence
    Summary · context
    Ninety-six children (54 boys and 42 girls, aged 4.1-17.4 yr) were studied.
  7. 07HumanNon-randomized trialEfficacy outcome

    In children, the GH increase after intravenous hexarelin 2 micrograms/kg was higher in pubertal than in prepubertal children.

    In plain wordsIn children, hexarelin raised GH more in those in puberty than in those before puberty.

    Peptide
    Hexarelin
    Outcome
    IncreaseGH response to hexarelin in pubertal versus prepubertal children
    Study

    n: not reported in source

    Comparator
    Prepubertal children
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    2 micrograms/kg · intravenousAs given in this study (human).

    Measurements

    GH increase
    77.5 micrograms/L
    pubertal children
    GH increase
    39.4 micrograms/L
    prepubertal children

    Source sentences

    Summary
    The iv dose of 2 micrograms/kg HEX elicited an increase in GH levels that was higher in pubertal children than in prepubertal children (77.5 +/- 8.5 vs. 39.4 +/- 4.4 micrograms/L; P < 0.001).
    1 context sentence
    Summary · context
    Ninety-six children (54 boys and 42 girls, aged 4.1-17.4 yr) were studied.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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