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Study · Randomized controlled trial · n = 12 · 1995

9 results

The effect of an opiate antagonist on the hormonal changes induced by hexarelin.

Korbonits M, Trainer PJ, Besser GM

Clinical endocrinology1 Sept 1995Cited by 23 (Europe PMC)

PMID7586608 (opens in a new tab)DOI10.1111/j.1365-2265.1995.tb02045.x (opens in a new tab)PepBankPUB-07586608
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

6 results from studies that gave the peptide. 6 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In 12 healthy volunteers, hexarelin significantly stimulated peak serum GH levels versus placebo.

    In plain wordsIn 12 healthy volunteers, hexarelin raised the peak growth hormone level more than placebo.

    Peptide
    Hexarelin
    Outcome
    IncreasePeak serum GH
    Study

    n = 12

    Comparator
    Placebo
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    2 micrograms/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    Hexarelin significantly stimulated the peak serum levels and area under the curve for circulating GH and this effect was not modulated by naloxone.
    1 context sentence
    Summary · context
    We have investigated the effects of 100 micrograms/kg i.v. dose of the opiate antagonist naloxone and 2 micrograms/kg i.v. hexarelin or placebo on serum GH, prolactin, TSH, cortisol and plasma ACTH in 12 healthy volunteers in a double-blind, randomized trial.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In 12 healthy volunteers, hexarelin significantly stimulated the area under the curve for circulating GH versus placebo.

    In plain wordsIn 12 healthy volunteers, hexarelin raised total growth hormone exposure more than placebo.

    Peptide
    Hexarelin
    Outcome
    IncreaseGH area under the curve
    Study

    n = 12

    Comparator
    Placebo
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    2 micrograms/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    Hexarelin significantly stimulated the peak serum levels and area under the curve for circulating GH and this effect was not modulated by naloxone.
    1 context sentence
    Summary · context
    We have investigated the effects of 100 micrograms/kg i.v. dose of the opiate antagonist naloxone and 2 micrograms/kg i.v. hexarelin or placebo on serum GH, prolactin, TSH, cortisol and plasma ACTH in 12 healthy volunteers in a double-blind, randomized trial.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In 12 healthy volunteers, hexarelin caused significant elevation of circulating prolactin versus placebo.

    In plain wordsIn 12 healthy volunteers, hexarelin raised prolactin levels more than placebo.

    Peptide
    Hexarelin
    Outcome
    IncreaseCirculating prolactin
    Study

    n = 12

    Comparator
    Placebo
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    2 micrograms/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    Hexarelin also caused significant elevation of circulating prolactin, cortisol and ACTH but did not influence circulating TSH levels.
    1 context sentence
    Summary · context
    We have investigated the effects of 100 micrograms/kg i.v. dose of the opiate antagonist naloxone and 2 micrograms/kg i.v. hexarelin or placebo on serum GH, prolactin, TSH, cortisol and plasma ACTH in 12 healthy volunteers in a double-blind, randomized trial.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In 12 healthy volunteers, hexarelin caused significant elevation of circulating cortisol versus placebo.

    In plain wordsIn 12 healthy volunteers, hexarelin raised cortisol levels more than placebo.

    Peptide
    Hexarelin
    Outcome
    IncreaseCirculating cortisol
    Study

    n = 12

    Comparator
    Placebo
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    2 micrograms/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    Hexarelin also caused significant elevation of circulating prolactin, cortisol and ACTH but did not influence circulating TSH levels.
    1 context sentence
    Summary · context
    We have investigated the effects of 100 micrograms/kg i.v. dose of the opiate antagonist naloxone and 2 micrograms/kg i.v. hexarelin or placebo on serum GH, prolactin, TSH, cortisol and plasma ACTH in 12 healthy volunteers in a double-blind, randomized trial.
  5. 05HumanRandomized controlled trialEfficacy outcome

    In 12 healthy volunteers, hexarelin caused significant elevation of circulating ACTH versus placebo.

    In plain wordsIn 12 healthy volunteers, hexarelin raised ACTH levels more than placebo.

    Peptide
    Hexarelin
    Outcome
    IncreaseCirculating ACTH
    Study

    n = 12

    Comparator
    Placebo
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    2 micrograms/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    Hexarelin also caused significant elevation of circulating prolactin, cortisol and ACTH but did not influence circulating TSH levels.
    1 context sentence
    Summary · context
    We have investigated the effects of 100 micrograms/kg i.v. dose of the opiate antagonist naloxone and 2 micrograms/kg i.v. hexarelin or placebo on serum GH, prolactin, TSH, cortisol and plasma ACTH in 12 healthy volunteers in a double-blind, randomized trial.
  6. 06HumanRandomized controlled trialEfficacy outcome

    In 12 healthy volunteers, hexarelin did not influence circulating TSH levels.

    In plain wordsIn 12 healthy volunteers, hexarelin did not change thyroid-stimulating hormone levels.

    Peptide
    Hexarelin
    Outcome
    No significant changeCirculating TSH
    Study

    n = 12

    Comparator
    Placebo
    Outcome group
    Pituitary hormones · Endocrine and hormones
    Studied dose
    2 micrograms/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    Hexarelin also caused significant elevation of circulating prolactin, cortisol and ACTH but did not influence circulating TSH levels.
    1 context sentence
    Summary · context
    We have investigated the effects of 100 micrograms/kg i.v. dose of the opiate antagonist naloxone and 2 micrograms/kg i.v. hexarelin or placebo on serum GH, prolactin, TSH, cortisol and plasma ACTH in 12 healthy volunteers in a double-blind, randomized trial.

Studies that did not test the peptide alone3

In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Hexarelin.

  1. 07HumanNot a test of Hexarelin aloneRandomized controlled trialMechanism

    In 12 healthy volunteers, the hexarelin-induced GH rise was not modulated by naloxone.

    In plain wordsIn 12 healthy volunteers, the opiate blocker naloxone did not change the growth hormone rise caused by hexarelin.

    Peptide
    Hexarelin
    Outcome
    No significant changeHexarelin GH response with naloxone
    Study

    n = 12

    Comparator
    Hexarelin without naloxone
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Source sentences

    Summary
    Hexarelin significantly stimulated the peak serum levels and area under the curve for circulating GH and this effect was not modulated by naloxone.
    1 context sentence
    Summary · context
    We have investigated the effects of 100 micrograms/kg i.v. dose of the opiate antagonist naloxone and 2 micrograms/kg i.v. hexarelin or placebo on serum GH, prolactin, TSH, cortisol and plasma ACTH in 12 healthy volunteers in a double-blind, randomized trial.

    In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.

  2. 08HumanNot a test of Hexarelin aloneRandomized controlled trialMechanism

    In 12 healthy volunteers, the combined effect of hexarelin and naloxone on cortisol was less than additive.

    In plain wordsIn 12 healthy volunteers, hexarelin and naloxone together raised cortisol less than the sum of each alone.

    Peptide
    Hexarelin
    Outcome
    DecreaseCortisol response to hexarelin plus naloxone
    Study

    n = 12

    Comparator
    Each drug alone
    Outcome group
    Pituitary hormones · Endocrine and hormones

    Source sentences

    Summary
    The effect of the two drugs together on cortisol and ACTH was less than additive.
    1 context sentence
    Summary · context
    We have investigated the effects of 100 micrograms/kg i.v. dose of the opiate antagonist naloxone and 2 micrograms/kg i.v. hexarelin or placebo on serum GH, prolactin, TSH, cortisol and plasma ACTH in 12 healthy volunteers in a double-blind, randomized trial.

    In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.

  3. 09HumanNot a test of Hexarelin aloneRandomized controlled trialMechanism

    In 12 healthy volunteers, the combined effect of hexarelin and naloxone on ACTH was less than additive.

    In plain wordsIn 12 healthy volunteers, hexarelin and naloxone together raised ACTH less than the sum of each alone.

    Peptide
    Hexarelin
    Outcome
    DecreaseACTH response to hexarelin plus naloxone
    Study

    n = 12

    Comparator
    Each drug alone
    Outcome group
    Pituitary hormones · Endocrine and hormones

    Source sentences

    Summary
    The effect of the two drugs together on cortisol and ACTH was less than additive.
    1 context sentence
    Summary · context
    We have investigated the effects of 100 micrograms/kg i.v. dose of the opiate antagonist naloxone and 2 micrograms/kg i.v. hexarelin or placebo on serum GH, prolactin, TSH, cortisol and plasma ACTH in 12 healthy volunteers in a double-blind, randomized trial.

    In this study, Hexarelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Hexarelin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 4 to 18Current

    28 Oct 2026, 02:02 UTC

    The same notice was added 15 times, first on 13 Oct 2026, 21:44 UTC. The status did not change between them.

    Study results updated

  2. Version 3

    13 Oct 2026, 16:31 UTC

    Study data updated · source update from Europe PMC

  3. Version 2

    12 Oct 2026, 12:58 UTC

    Study results updated

  4. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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