After hexarelin alone, patients with glucocorticoid excess showed no significant difference in GH response compared with normal subjects.
In plain wordsIn people with excess glucocorticoids, hexarelin raised growth hormone about as much as in healthy people.
- Peptide
- Hexarelin
- Outcome
- No significant changeGH response to hexarelin in glucocorticoid excess versus normal subjects
- Study
n: not reported in source
- Comparator
- Normal subjects
- Outcome group
- Growth hormone and IGF-1 · Endocrine and hormones
- Studied dose
- 100 micrograms · intravenousAs given in this study (human).
Measurements
- Median delta GH
- 15.5 micrograms/l
- steroid-treated group
- Median delta GH
- 17.9 micrograms/l
- normal subjects
Source sentences
No significant differences were observed in the steroid-treated group with respect to normal subjects after hexarelin alone (median delta GH: 15.5, range 1.9-45.2 micrograms/l vs 17.9, range 5.5-53.9 micrograms/l).(ABSTRACT TRUNCATED AT 250 WORDS)
2 context sentences(design, population, supporting numbers)
We studied seven adult patients undergoing long-term (no less than 6 months) immunosuppressive glucocorticoid treatment for non-endocrine diseases (six females and one male, age range 42-68 years) and one subject (female, age 31 years) with endogenous hypercortisolism due to adrenal adenoma.
All the subjects underwent the following three tests in random order: (1) human GHRH (1-29)NH2 (100 micrograms in 1 ml saline) injected as an i.v. bolus at 0 min, (2) hexarelin (100 micrograms in 1 ml saline) injected as an i.v. bolus at 0 min and (3) hexarelin (100 micrograms in 1 ml of saline) plu…