Skip to content

Study · Animal study (in vivo) · rat · 1995

6 results

Desmopressin induces endothelial P-selectin expression and leukocyte rolling in postcapillary venules.

Kanwar S, Woodman RC, Poon MC, Murohara T, Lefer AM, Davenpeck KL, Kubes P

Blood1 Oct 1995Cited by 42 (Europe PMC)

PMID7545469 (opens in a new tab)DOI10.1182/blood.v86.7.2760.2760 (opens in a new tab)PepBankPUB-07545469
Publisher pagePubMedAsk about this study
Jump to 6 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In rats, intravenous DDAVP induced significant endothelial P-selectin expression compared with saline.

    In plain wordsIn rats, DDAVP increased endothelial P-selectin expression compared with saline.

    Peptide
    Desmopressin
    Outcome
    IncreaseEndothelial P-selectin expression
    Study

    ratn: not reported in source

    Postcapillary venules
    Comparator
    Saline
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    1 microgram/kg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    Immunohistochemical analysis of rat postcapillary venules showed that in contrast to saline, DDAVP injection (1 microgram/kg, intravenous) induced significant endothelial P-selectin expression.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats, DDAVP rapidly and significantly increased leukocyte rolling in mesenteric venules in vivo.

    In plain wordsIn rats, DDAVP increased white blood cell rolling in mesenteric venules.

    Peptide
    Desmopressin
    Outcome
    IncreaseLeukocyte rolling
    Study

    ratn: not reported in source

    Postcapillary venules
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    1 microgram/kg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    DDAVP administration also induced a rapid and significant increase in leukocyte rolling in rat mesenteric venules in vivo.
    1 context sentence
    Summary · context
    Immunohistochemical analysis of rat postcapillary venules showed that in contrast to saline, DDAVP injection (1 microgram/kg, intravenous) induced significant endothelial P-selectin expression.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats, DDAVP induced leukocyte rolling in medium postcapillary venules (20 to 40 microns).

    In plain wordsIn rats, DDAVP induced white blood cell rolling in medium postcapillary venules.

    Peptide
    Desmopressin
    Outcome
    IncreaseLeukocyte rolling in medium venules
    Study

    ratn: not reported in source

    Postcapillary venules
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    1 microgram/kg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    DDAVP induced leukocyte rolling in medium (20 to 40 microns) and large (> 40 microns), but not small (< 20 microns), postcapillary venules.
    1 context sentence
    Summary · context
    Immunohistochemical analysis of rat postcapillary venules showed that in contrast to saline, DDAVP injection (1 microgram/kg, intravenous) induced significant endothelial P-selectin expression.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats treated with DDAVP, leukocyte adhesion increased steadily and significantly.

    In plain wordsIn rats, white blood cell adhesion increased during DDAVP treatment.

    Peptide
    Desmopressin
    Outcome
    IncreaseLeukocyte adhesion
    Study

    ratn: not reported in source

    Postcapillary venules
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    1 microgram/kg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    In animals that were treated with DDAVP, there was a steady and significant increase in leukocyte adhesion.
    1 context sentence
    Summary · context
    Immunohistochemical analysis of rat postcapillary venules showed that in contrast to saline, DDAVP injection (1 microgram/kg, intravenous) induced significant endothelial P-selectin expression.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats, DDAVP induced leukocyte rolling in large postcapillary venules (> 40 microns).

    In plain wordsIn rats, DDAVP induced white blood cell rolling in large postcapillary venules.

    Peptide
    Desmopressin
    Outcome
    IncreaseLeukocyte rolling in large venules
    Study

    ratn: not reported in source

    Postcapillary venules
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    1 microgram/kg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    DDAVP induced leukocyte rolling in medium (20 to 40 microns) and large (> 40 microns), but not small (< 20 microns), postcapillary venules.
    1 context sentence
    Summary · context
    Immunohistochemical analysis of rat postcapillary venules showed that in contrast to saline, DDAVP injection (1 microgram/kg, intravenous) induced significant endothelial P-selectin expression.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In rats, DDAVP did not induce leukocyte rolling in small postcapillary venules (< 20 microns).

    In plain wordsIn rats, DDAVP did not induce white blood cell rolling in small postcapillary venules.

    Peptide
    Desmopressin
    Outcome
    No significant changeLeukocyte rolling in small venules
    Study

    ratn: not reported in source

    Postcapillary venules
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    1 microgram/kg · intravenousAs given in this study (rat).

    Source sentences

    Summary
    DDAVP induced leukocyte rolling in medium (20 to 40 microns) and large (> 40 microns), but not small (< 20 microns), postcapillary venules.
    1 context sentence
    Summary · context
    Immunohistochemical analysis of rat postcapillary venules showed that in contrast to saline, DDAVP injection (1 microgram/kg, intravenous) induced significant endothelial P-selectin expression.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.