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Study · Measured the body's own peptide · 1995

4 results

Regulation of thymosin beta 4 mRNA levels during cell proliferation.

Zalvide JB, Alvarez CV, Vidal A, Dieguez C, Vega FV, Domínguez F

Cell proliferation1 Feb 1995Cited by 8 (Europe PMC)

PMID7534483 (opens in a new tab)DOI10.1111/j.1365-2184.1995.tb00057.x (opens in a new tab)PepBankPUB-07534483
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01LabEndogenous levelIn vitro (cells)Other

    In serum-deprived NIH 3T3 cells, thymosin beta‑4 mRNA was undetectable at rest and rose markedly at the G1/S transition after serum restoration.

    In plain wordsIn mouse cells in the lab, natural thymosin beta‑4 messenger RNA was undetectable at rest and rose strongly when the cells began to grow.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseThymosin beta 4 mRNA after serum restoration
    Study

    mousen: not reported in source

    NIH 3T3 cells
    Outcome group
    Gene expression · Whole body

    Source sentences

    Summary
    In serum deprived, quiescent cells, the levels of thymosin beta 4 were undetectable; after serum restoration, the cells were induced to proliferate and we found a pronounced increase in thymosin beta 4 mRNA levels at the G1/S transition.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  2. 02LabEndogenous levelIn vitro (cells)Other

    In NIH 3T3 cells, thymosin beta‑4 mRNA was induced even in the presence of cycloheximide.

    In plain wordsIn mouse cells in the lab, natural thymosin beta‑4 messenger RNA rose even when protein making was blocked.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseThymosin beta 4 mRNA induction with cycloheximide
    Study

    mousen: not reported in source

    NIH 3T3 cells
    Outcome group
    Gene expression · Whole body

    Source sentences

    Summary
    Thymosin beta 4 mRNA was induced even in the presence of cycloheximide.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  3. 03LabEndogenous levelIn vitro (cells)Other

    In NIH 3T3 cells synchronized at different cell-cycle stages, thymosin beta‑4 mRNA levels did not vary as cells progressed through the cycle.

    In plain wordsIn mouse cells in the lab, natural thymosin beta‑4 messenger RNA levels did not change across the stages of the cell cycle.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    No significant changeThymosin beta 4 mRNA across the cell cycle
    Study

    mousen: not reported in source

    NIH 3T3 cells
    Outcome group
    Gene expression · Whole body

    Source sentences

    Summary
    On the other hand, cycling cells that were synchronized at different stages of the cycle by means of mitotic shake-off after nocodazole arrest or a double thymidine block did not show any variation in the levels of thymosin beta 4 mRNA when they progressed synchronously through the cycle.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  4. 04LabEndogenous levelIn vitro (cells)Other

    In NIH 3T3 cells, results suggest that thymosin beta‑4 mRNA is highly stable after blocking transcription with actinomycin D.

    In plain wordsIn mouse cells in the lab, natural thymosin beta‑4 messenger RNA appeared very stable after gene reading was blocked.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableThymosin beta 4 mRNA stability
    Study

    mousen: not reported in source

    NIH 3T3 cells
    Outcome group
    Gene expression · Whole body

    Source sentences

    Summary
    Finally, we studied thymosin beta 4 mRNA stability by inhibiting thymosin beta 4 gene transcription with actinomycin D. Our results suggest that thymosin beta 4 mRNA has a pronounced stability, a fact that might be relevant to account for the presence of thymosin beta 4 in enucleated cells like platelets.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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