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Study · Case report or series · n = 1 · 1994

2 results

Prophylaxis and reversal of ifosfamide encephalopathy with methylene-blue.

Küpfer A, Aeschlimann C, Wermuth B, Cerny T

Lancet (London, England)1 Mar 1994Cited by 108 (Europe PMC)

PMID7510815 (opens in a new tab)DOI10.1016/s0140-6736(94)91839-2 (opens in a new tab)PepBankPUB-07510815
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. 2 results from people.

  1. 01HumanCase report or seriesEfficacy outcome

    In a patient with ifosfamide encephalopathy, intravenous methylene blue rapidly reversed neurotoxicity.

    In plain wordsIntravenous methylene blue rapidly reversed ifosfamide neurotoxicity in one patient.

    Peptide
    Methylene blue
    Outcome
    DecreaseReversal of ifosfamide neurotoxicity
    Study

    n = 1

    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    50 mg · intravenousAs given in this study (human).

    Source sentences

    Summary
    In one patient, ifosfamide neurotoxicity was rapidly reversed by methylene-blue 50 mg intravenously.
  2. 02HumanCase report or seriesEfficacy outcome

    In another patient with previous ifosfamide encephalopathy, no neurotoxicity symptoms occurred during oral methylene blue prophylaxis.

    In plain wordsNo neurotoxicity symptoms occurred during oral methylene blue prophylaxis in a patient with previous ifosfamide encephalopathy.

    Peptide
    Methylene blue
    Outcome
    Not applicableNeurotoxicity during prophylaxis
    Study

    n = 1

    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · oralAs given in this study (human).

    Source sentences

    Summary
    No symptoms of neurotoxicity were noted.
    1 context sentence
    Summary · context
    In another patient with previous episodes of ifosfamide encephalopathy, methylene-blue was administered orally prophylactically.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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