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Study · Animal study (in vivo) · mouse · 1981

2 results

Modulation of terminal deoxynucleotidyl transferase activity by thymosin.

Hu SK, Low TL, Goldstein AL

Molecular and cellular biochemistry1 Dec 1981Cited by 36 (Europe PMC)

PMID7329413 (opens in a new tab)DOI10.1007/bf00225296 (opens in a new tab)PepBankPUB-07329413
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In immune suppressed mice, daily injection of thymosin beta‑4 significantly increased terminal deoxynucleotidyl transferase (TdT) activity compared with control groups.

    In plain wordsIn immune suppressed mice, daily thymosin beta‑4 injections raised TdT activity, an immune cell marker, more than in control groups.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseTdT activity in immune suppressed mice
    Study

    mousen: not reported in source

    Comparator
    Control groups
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · dailyAs given in this study (mouse).

    Source sentences

    Summary
    The daily injection of thymosin fraction 5 and two of its components, thymosin beta 3 and beta 4, significantly increases TdT activity in immune suppressed mice as compared to control groups.
  2. 02LabEx vivo tissueActivity measurement

    In normal murine thymocytes, purified thymosin alpha‑1 had high activity in decreasing TdT after a 22-h incubation.

    In plain wordsIn mouse thymus cells in lab tests, thymosin alpha‑1 strongly lowered an enzyme linked to T-cell maturation.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseTerminal deoxynucleotidyl transferase (TdT) activity in normal thymocytes
    Study

    mousen: not reported in source

    Normal murine thymocytes, 22-h incubation
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · 22 hoursAs given in this study (mouse).

    Source sentences

    Summary
    In an in vivo system, thymosin fraction 5 and the purified peptide, thymosin alpha 1, have high activities in decreasing TdT in normal murine thymocytes after a 22-h incubation.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 4Current

    12 Oct 2026, 18:17 UTC

    Study data updated · source update from Europe PMC

  2. Version 3

    10 Oct 2026, 08:55 UTC

    Study results updated

  3. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  4. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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