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Study · Animal study (in vivo) · mouse · 1980

5 results

[Effect of substances of a polypeptide nature isolated from the thymus and cerebral cortex on the primary immune response of mice to thymus-dependent and thymus-independent antigen].

Belokrylov GA, Khavinson VKh, Morozov VG

Zhurnal mikrobiologii, epidemiologii i immunobiologii1 Mar 1980

PMID7191185 (opens in a new tab)PepBankPUB-07191185
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Activity measurement

    In CBA mice immunized with SRBC, cortexin stimulated direct IgM antibody-producing cell production.

    In plain wordsIn mice immunized with SRBC, cortexin increased production of cells that make IgM antibodies.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    IncreaseIgM antibody-producing cells after SRBC immunization
    Study

    mousen: not reported in source

    CBA mice immunized with SRBC or Vi-antigen
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · injection · 5 days before and 3 days after SRBC immunizationAs given in this study (mouse).

    Source sentences

    Summary
    showed that the injection of the preparation obtained from the cerebral cortex (cortexin) or the thymus (thymarin) for 5 days before and for 3 days after SRBc immunization stimulated the production of both direct (IgM) and indirect (IgG) antibody-producing cells, as well as the production of hemagglutinins.
    1 context sentence
    Summary · context
    The study of the effect of low molecular polypeptides on the primary immune response induced in CBA mice by the injection of thymus-dependent antigen (SRBC)
  2. 02AnimalAnimal study (in vivo)Activity measurement

    In CBA mice immunized with SRBC, cortexin stimulated indirect IgG antibody-producing cell production.

    In plain wordsIn mice immunized with SRBC, cortexin increased production of cells that make IgG antibodies.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    IncreaseIgG antibody-producing cells after SRBC immunization
    Study

    mousen: not reported in source

    CBA mice immunized with SRBC or Vi-antigen
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · injection · 5 days before and 3 days after SRBC immunizationAs given in this study (mouse).

    Source sentences

    Summary
    showed that the injection of the preparation obtained from the cerebral cortex (cortexin) or the thymus (thymarin) for 5 days before and for 3 days after SRBc immunization stimulated the production of both direct (IgM) and indirect (IgG) antibody-producing cells, as well as the production of hemagglutinins.
    1 context sentence
    Summary · context
    The study of the effect of low molecular polypeptides on the primary immune response induced in CBA mice by the injection of thymus-dependent antigen (SRBC)
  3. 03AnimalAnimal study (in vivo)Activity measurement

    In CBA mice immunized with SRBC, cortexin stimulated hemagglutinin production.

    In plain wordsIn mice immunized with SRBC, cortexin increased hemagglutinin production.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    IncreaseHemagglutinins after SRBC immunization
    Study

    mousen: not reported in source

    CBA mice immunized with SRBC or Vi-antigen
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · injection · 5 days before and 3 days after SRBC immunizationAs given in this study (mouse).

    Source sentences

    Summary
    showed that the injection of the preparation obtained from the cerebral cortex (cortexin) or the thymus (thymarin) for 5 days before and for 3 days after SRBc immunization stimulated the production of both direct (IgM) and indirect (IgG) antibody-producing cells, as well as the production of hemagglutinins.
    1 context sentence
    Summary · context
    The study of the effect of low molecular polypeptides on the primary immune response induced in CBA mice by the injection of thymus-dependent antigen (SRBC)
  4. 04AnimalAnimal study (in vivo)Activity measurement

    In CBA mice, cortexin suppressed production of antibody-producing cells against Vi-antigen.

    In plain wordsIn mice, cortexin suppressed production of cells that make antibodies against Vi-antigen.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    DecreaseAntibody-producing cells against Vi-antigen
    Study

    mousen: not reported in source

    CBA mice immunized with SRBC or Vi-antigen
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · injectionAs given in this study (mouse).

    Source sentences

    Summary
    At the same time the production of antibody-producing cells and antibodies to Vi-antigen was suppressed.
    1 context sentence
    Summary · context
    The study of the effect of low molecular polypeptides on the primary immune response induced in CBA mice by the injection of thymus-dependent antigen (SRBC)
  5. 05AnimalAnimal study (in vivo)Activity measurement

    In CBA mice, cortexin suppressed antibody production against Vi-antigen.

    In plain wordsIn mice, cortexin suppressed antibody production against Vi-antigen.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    DecreaseAntibodies against Vi-antigen
    Study

    mousen: not reported in source

    CBA mice immunized with SRBC or Vi-antigen
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · injectionAs given in this study (mouse).

    Source sentences

    Summary
    At the same time the production of antibody-producing cells and antibodies to Vi-antigen was suppressed.
    1 context sentence
    Summary · context
    The study of the effect of low molecular polypeptides on the primary immune response induced in CBA mice by the injection of thymus-dependent antigen (SRBC)

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:25 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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