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Study · Non-randomized trial · n = 37 · 1982

8 results

Effect of exogenous glucagon on left-ventricular contraction dynamics during restitution after exercise in healthy men.

Markiewicz K, Cholewa M, Górski L

Acta physiologica Polonica1 May 1982

PMID7180523 (opens in a new tab)PepBankPUB-07180523
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. 8 results from people.

  1. 01HumanNon-randomized trialActivity measurement

    In healthy men, glucagon before exercise reduced left ventricular functional reserve during exercise.

    In plain wordsIn healthy men, glucagon reduced the left ventricle's functional reserve during exercise compared with control.

    Peptide
    Glucagon
    Outcome
    DecreaseLeft ventricular functional reserve
    Study

    n = 37

    Comparator
    Control group performing the same exercise
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    50 micrograms/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    Glucagon administration before the exercise reduced the functional reserve of the left ventricle during the exercise impairing the pumping action of the left ventricle during the restitution.
    3 context sentences
    Summary · context
    In two groups of healthy men the dynamics of left-ventricular contraction was studied by Weissler's method based on synchronous recording of ECG, phonocardiogram and carotid sphygmogram.
    Summary · context
    Group I comprised 20 subjects in whom this recording was performed during maximal exercise and 90-minute restitution (1 W/kg/6 min, 2 W/kg/6 min, 3 W/kg/6 min).
    Summary · context
    Group II (n = 17) performed the same exercise immediately after intravenous injection of glucagon 50 micrograms/kg of body weight.
  2. 02HumanNon-randomized trialActivity measurement

    In healthy men, glucagon before exercise impaired left ventricular pumping during restitution.

    In plain wordsIn healthy men, glucagon before exercise impaired heart pumping during recovery compared with control.

    Peptide
    Glucagon
    Outcome
    DecreaseLeft ventricular pumping during restitution
    Study

    n = 37

    Comparator
    Control group performing the same exercise
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    50 micrograms/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    Glucagon administration before the exercise reduced the functional reserve of the left ventricle during the exercise impairing the pumping action of the left ventricle during the restitution.
    3 context sentences
    Summary · context
    In two groups of healthy men the dynamics of left-ventricular contraction was studied by Weissler's method based on synchronous recording of ECG, phonocardiogram and carotid sphygmogram.
    Summary · context
    Group I comprised 20 subjects in whom this recording was performed during maximal exercise and 90-minute restitution (1 W/kg/6 min, 2 W/kg/6 min, 3 W/kg/6 min).
    Summary · context
    Group II (n = 17) performed the same exercise immediately after intravenous injection of glucagon 50 micrograms/kg of body weight.
  3. 03HumanNon-randomized trialActivity measurement

    In healthy men, glucagon reduced the left ventricular ejection time index during postexercise restitution versus controls.

    In plain wordsIn healthy men, glucagon reduced the heart's ejection time index during recovery compared with control.

    Peptide
    Glucagon
    Outcome
    DecreaseLeft ventricular ejection time index
    Study

    n = 37

    Comparator
    Control group performing the same exercise
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    50 micrograms/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    After glucagon administration the restitution of left-ventricular contraction periods was characterized by decreased value of the ejection time index (LVETI), prolonged pre-ejection period (PEP), isovolumetric contraction time (ICT), and diminished LVET/PEP index in relation to the values obtained a…
    3 context sentences
    Summary · context
    In two groups of healthy men the dynamics of left-ventricular contraction was studied by Weissler's method based on synchronous recording of ECG, phonocardiogram and carotid sphygmogram.
    Summary · context
    Group I comprised 20 subjects in whom this recording was performed during maximal exercise and 90-minute restitution (1 W/kg/6 min, 2 W/kg/6 min, 3 W/kg/6 min).
    Summary · context
    Group II (n = 17) performed the same exercise immediately after intravenous injection of glucagon 50 micrograms/kg of body weight.
  4. 04HumanNon-randomized trialActivity measurement

    In healthy men, glucagon prolonged the pre-ejection period during postexercise restitution versus controls.

    In plain wordsIn healthy men, glucagon prolonged the heart's pre-ejection period during recovery compared with control.

    Peptide
    Glucagon
    Outcome
    IncreasePre-ejection period
    Study

    n = 37

    Comparator
    Control group performing the same exercise
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    50 micrograms/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    After glucagon administration the restitution of left-ventricular contraction periods was characterized by decreased value of the ejection time index (LVETI), prolonged pre-ejection period (PEP), isovolumetric contraction time (ICT), and diminished LVET/PEP index in relation to the values obtained a…
    3 context sentences
    Summary · context
    In two groups of healthy men the dynamics of left-ventricular contraction was studied by Weissler's method based on synchronous recording of ECG, phonocardiogram and carotid sphygmogram.
    Summary · context
    Group I comprised 20 subjects in whom this recording was performed during maximal exercise and 90-minute restitution (1 W/kg/6 min, 2 W/kg/6 min, 3 W/kg/6 min).
    Summary · context
    Group II (n = 17) performed the same exercise immediately after intravenous injection of glucagon 50 micrograms/kg of body weight.
  5. 05HumanNon-randomized trialActivity measurement

    In healthy men, glucagon prolonged isovolumetric contraction time during postexercise restitution versus controls.

    In plain wordsIn healthy men, glucagon prolonged isovolumetric contraction time during recovery compared with control.

    Peptide
    Glucagon
    Outcome
    IncreaseIsovolumetric contraction time
    Study

    n = 37

    Comparator
    Control group performing the same exercise
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    50 micrograms/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    After glucagon administration the restitution of left-ventricular contraction periods was characterized by decreased value of the ejection time index (LVETI), prolonged pre-ejection period (PEP), isovolumetric contraction time (ICT), and diminished LVET/PEP index in relation to the values obtained a…
    3 context sentences
    Summary · context
    In two groups of healthy men the dynamics of left-ventricular contraction was studied by Weissler's method based on synchronous recording of ECG, phonocardiogram and carotid sphygmogram.
    Summary · context
    Group I comprised 20 subjects in whom this recording was performed during maximal exercise and 90-minute restitution (1 W/kg/6 min, 2 W/kg/6 min, 3 W/kg/6 min).
    Summary · context
    Group II (n = 17) performed the same exercise immediately after intravenous injection of glucagon 50 micrograms/kg of body weight.
  6. 06HumanNon-randomized trialActivity measurement

    In healthy men, glucagon reduced the LVET/PEP index during postexercise restitution versus controls.

    In plain wordsIn healthy men, glucagon reduced the ratio of ejection time to pre-ejection period during recovery compared with control.

    Peptide
    Glucagon
    Outcome
    DecreaseLVET/PEP index
    Study

    n = 37

    Comparator
    Control group performing the same exercise
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    50 micrograms/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    After glucagon administration the restitution of left-ventricular contraction periods was characterized by decreased value of the ejection time index (LVETI), prolonged pre-ejection period (PEP), isovolumetric contraction time (ICT), and diminished LVET/PEP index in relation to the values obtained a…
    3 context sentences
    Summary · context
    In two groups of healthy men the dynamics of left-ventricular contraction was studied by Weissler's method based on synchronous recording of ECG, phonocardiogram and carotid sphygmogram.
    Summary · context
    Group I comprised 20 subjects in whom this recording was performed during maximal exercise and 90-minute restitution (1 W/kg/6 min, 2 W/kg/6 min, 3 W/kg/6 min).
    Summary · context
    Group II (n = 17) performed the same exercise immediately after intravenous injection of glucagon 50 micrograms/kg of body weight.
  7. 07HumanNon-randomized trialActivity measurement

    In healthy men, glucagon did not change exercise tolerance versus control.

    In plain wordsIn healthy men, glucagon did not change exercise tolerance compared with control.

    Peptide
    Glucagon
    Outcome
    No significant changeExercise tolerance
    Study

    n = 37

    Comparator
    Control group performing the same exercise
    Outcome group
    Exercise and physical function · Whole body
    Studied dose
    50 micrograms/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    Glucagon caused no changes in the exercise tolerance of the studied subjects and had no effect on the time of postexercise restitution.
    3 context sentences
    Summary · context
    In two groups of healthy men the dynamics of left-ventricular contraction was studied by Weissler's method based on synchronous recording of ECG, phonocardiogram and carotid sphygmogram.
    Summary · context
    Group I comprised 20 subjects in whom this recording was performed during maximal exercise and 90-minute restitution (1 W/kg/6 min, 2 W/kg/6 min, 3 W/kg/6 min).
    Summary · context
    Group II (n = 17) performed the same exercise immediately after intravenous injection of glucagon 50 micrograms/kg of body weight.
  8. 08HumanNon-randomized trialActivity measurement

    In healthy men, glucagon did not affect the time of postexercise restitution versus control.

    In plain wordsIn healthy men, glucagon did not affect recovery time after exercise compared with control.

    Peptide
    Glucagon
    Outcome
    No significant changeTime of postexercise restitution
    Study

    n = 37

    Comparator
    Control group performing the same exercise
    Outcome group
    Exercise and physical function · Cardiovascular
    Studied dose
    50 micrograms/kg · intravenousAs given in this study (human).

    Source sentences

    Summary
    Glucagon caused no changes in the exercise tolerance of the studied subjects and had no effect on the time of postexercise restitution.
    3 context sentences
    Summary · context
    In two groups of healthy men the dynamics of left-ventricular contraction was studied by Weissler's method based on synchronous recording of ECG, phonocardiogram and carotid sphygmogram.
    Summary · context
    Group I comprised 20 subjects in whom this recording was performed during maximal exercise and 90-minute restitution (1 W/kg/6 min, 2 W/kg/6 min, 3 W/kg/6 min).
    Summary · context
    Group II (n = 17) performed the same exercise immediately after intravenous injection of glucagon 50 micrograms/kg of body weight.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

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Terms as the source lists them.

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